Piperolein B, isopiperolein B and piperamide C9:1(8E): Total synthesis and cytotoxicities

Kayamba, Francis; Dunnill, Christopher; Hamnett, David J.; Rodríguez, Arantxa; Georgopoulos, Nikolaos T.; Moran, Wesley J.

Abstract

Total syntheses of the reported structures of piperolein B, isopiperolein B and piperamide C9:1(8E) have been achieved. The analytical data reported for piperolein B and piperamide C9:1(8E) match the synthetic values, however those for isopiperolein B do not. The cytotoxicities of these three structurally similar compounds against cancer cell lines of different tissue origins were evaluated and the results indicated that these compounds show differential effects on cancer cell viability.

Citation

Kayamba, F., Dunnill, C., Hamnett, D. J., Rodríguez, A., Georgopoulos, N. T., & Moran, W. J. (2013). Piperolein B, isopiperolein B and piperamide C9:1(8E): Total synthesis and cytotoxicities. RSC advances, 3(37), 16681-16685. https://doi.org/10.1039/c3ra42060d

• Journal Article Type: Article
• Acceptance Date: Jul 15, 2013
• Online Publication Date: Jul 15, 2013
• Publication Date: 2013
• Deposit Date: May 22, 2024
• Journal: RSC Advances
• Print ISSN: 2046-2069
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 37
• Pages: 16681-16685
• DOI: https://doi.org/10.1039/c3ra42060d
• Public URL: https://keele-repository.worktribe.com/output/764025