Irfan Ahmad
Is it too early to recommend local treatment in oligometastatic NSCLC: a plea for equipoise
Ahmad, Irfan; Chufal, Kundan Singh; Miller, Alexis Andrew; Bajpai, Ram; Umesh, Preetha; Dawer, Aashita; Tandon, Sarthak; Gandhidasan, Senthilkumar; Dua, Bharat; Bhatia, Kratika; Gairola, Munish
Authors
Kundan Singh Chufal
Alexis Andrew Miller
Dr Ram Bajpai r.bajpai@keele.ac.uk
Preetha Umesh
Aashita Dawer
Sarthak Tandon
Senthilkumar Gandhidasan
Bharat Dua
Kratika Bhatia
Munish Gairola
Contributors
Dr Ram Bajpai r.bajpai@keele.ac.uk
Other
Abstract
Oligometastatic Non-Small Cell Lung cancer (OMD NSCLC) has been proposed to bridge the spectrum between non-metastatic to widely metastatic states and is perceived as an opportunity for potential cure if removed. Twelve clinical trials on local treatment have been reported, yet none are conclusive. These trials informed the development of a joint clinical practice guideline (CPG) by the American & European societies for radiation oncology, which endorses local treatment for OMD NSCLC. However, the heterogeneity between and prognostic factors within these trials likely influenced outcomes and can only support guidance at this time. Caution against an uncritical acceptance of the guideline is discussed, as strong recommendations are offered based on expert opinion and inconclusive evidence. The guideline is also examined by a patient’s caregiver, who emphasizes that uncertain evidence impedes shared decision-making.
Citation
Ahmad, I., Chufal, K. S., Miller, A. A., Bajpai, R., Umesh, P., Dawer, A., …Gairola, M. (in press). Is it too early to recommend local treatment in oligometastatic NSCLC: a plea for equipoise. British Journal of Radiology, 97(1157), 913-919. https://doi.org/10.1093/bjr/tqae068
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 21, 2024 |
Online Publication Date | Mar 27, 2024 |
Deposit Date | Apr 4, 2024 |
Publicly Available Date | Mar 28, 2025 |
Journal | British Journal of Radiology |
Print ISSN | 0007-1285 |
Electronic ISSN | 1748-880X |
Publisher | British Institute of Radiology |
Peer Reviewed | Peer Reviewed |
Volume | 97 |
Issue | 1157 |
Pages | 913-919 |
DOI | https://doi.org/10.1093/bjr/tqae068 |
Keywords | Radiology, Nuclear Medicine and imaging; General Medicine |
Public URL | https://keele-repository.worktribe.com/output/790257 |
Files
This file is under embargo until Mar 28, 2025 due to copyright reasons.
Contact r.bajpai@keele.ac.uk to request a copy for personal use.
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