Skip to main content

Research Repository

Advanced Search

Is it too early to recommend local treatment in oligometastatic NSCLC: a plea for equipoise

Ahmad, Irfan; Chufal, Kundan Singh; Miller, Alexis Andrew; Bajpai, Ram; Umesh, Preetha; Dawer, Aashita; Tandon, Sarthak; Gandhidasan, Senthilkumar; Dua, Bharat; Bhatia, Kratika; Gairola, Munish

Authors

Irfan Ahmad

Kundan Singh Chufal

Alexis Andrew Miller

Preetha Umesh

Aashita Dawer

Sarthak Tandon

Senthilkumar Gandhidasan

Bharat Dua

Kratika Bhatia

Munish Gairola



Contributors

Abstract

Oligometastatic Non-Small Cell Lung cancer (OMD NSCLC) has been proposed to bridge the spectrum between non-metastatic to widely metastatic states and is perceived as an opportunity for potential cure if removed. Twelve clinical trials on local treatment have been reported, yet none are conclusive. These trials informed the development of a joint clinical practice guideline (CPG) by the American & European societies for radiation oncology, which endorses local treatment for OMD NSCLC. However, the heterogeneity between and prognostic factors within these trials likely influenced outcomes and can only support guidance at this time. Caution against an uncritical acceptance of the guideline is discussed, as strong recommendations are offered based on expert opinion and inconclusive evidence. The guideline is also examined by a patient’s caregiver, who emphasizes that uncertain evidence impedes shared decision-making.

Citation

Ahmad, I., Chufal, K. S., Miller, A. A., Bajpai, R., Umesh, P., Dawer, A., …Gairola, M. (in press). Is it too early to recommend local treatment in oligometastatic NSCLC: a plea for equipoise. British Journal of Radiology, 97(1157), 913-919. https://doi.org/10.1093/bjr/tqae068

Journal Article Type Article
Acceptance Date Mar 21, 2024
Online Publication Date Mar 27, 2024
Deposit Date Apr 4, 2024
Publicly Available Date Mar 28, 2025
Journal British Journal of Radiology
Print ISSN 0007-1285
Electronic ISSN 1748-880X
Publisher British Institute of Radiology
Peer Reviewed Peer Reviewed
Volume 97
Issue 1157
Pages 913-919
DOI https://doi.org/10.1093/bjr/tqae068
Keywords Radiology, Nuclear Medicine and imaging; General Medicine
Public URL https://keele-repository.worktribe.com/output/790257