Kundan Chufal
Cardiac markers in left-sided breast cancer patients receiving adjuvant radiotherapy: a prospective study
Chufal, Kundan; Ahmad, Irfan; Prakash, Anuj; Miller, Alexis; Umesh, Preetha; Koul, Varsha; Bajpai, Ram; Dua, Bharat; Gupta, Priya; Gairola, Munish
Authors
Irfan Ahmad
Anuj Prakash
Alexis Miller
Preetha Umesh
Varsha Koul
Dr Ram Bajpai r.bajpai@keele.ac.uk
Bharat Dua
Priya Gupta
Munish Gairola
Abstract
Objectives
To investigate the association between radiotherapy (RT) and cardiac biomarkers in women with left-sided breast cancer.
Methods
This prospective observational study recruited patients with stage I-III left-sided breast cancer without coronary heart disease who required adjuvant RT. High-sensitivity troponin I(hsTnI), N-terminal pro-brain natriuretic peptide(NT-proBNP), and high-sensitivity C-reactive protein(hsCRP) levels were measured pre-RT, immediately after RT, and 3 months post-RT. Cardiac-sparing RT techniques were utilized (Field-in-Field IMRT/VMAT ± voluntary deep inspiration breath-hold). Statistical analyses were performed using non-parametric tests and multivariable quantile regression (QR).
Results
One hundred five patients completed the study, with 63 evaluable at three months post-RT. Pre- and post-RT biomarkers showed no significant differences. Median pre-RT and post-RT values were: hsTnI (0.012ng/mL; 0.012ng/mL), hsCRP (3.1 mg/L; 2.8 mg/L), and NT-proBNP (59pg/mL; 45pg/mL). Three months post-RT, hsTnI, hsCRP and NT-proBNP levels also showed no significant differences. Multivariable QR revealed no association between heart Dmean [median(IQR): 2.87 Gy (2.05–3.94)] and post-RT biomarkers. Age and BMI were associated with hsCRP and NT-proBNP, respectively.
Conclusions
hsTnI, NT-proBNP, and hsCRP are not correlated with contemporary low cardiac exposure in left-sided breast cancer patients treated with contemporary RT techniques.
Citation
Chufal, K., Ahmad, I., Prakash, A., Miller, A., Umesh, P., Koul, V., …Gairola, M. (in press). Cardiac markers in left-sided breast cancer patients receiving adjuvant radiotherapy: a prospective study. Cardio-Oncology, 10(1), Article 21. https://doi.org/10.1186/s40959-024-00225-1
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 25, 2024 |
Online Publication Date | Apr 8, 2024 |
Deposit Date | Apr 15, 2024 |
Publicly Available Date | Apr 15, 2024 |
Journal | Cardio-Oncology |
Electronic ISSN | 2057-3804 |
Publisher | Springer Nature [academic journals on nature.com] |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Issue | 1 |
Article Number | 21 |
DOI | https://doi.org/10.1186/s40959-024-00225-1 |
Keywords | Breast cancer, Hypofractionated Radiotherapy, NT-proBNP, hsTnI, hsCRP |
Public URL | https://keele-repository.worktribe.com/output/793937 |
Publisher URL | https://cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-024-00225-1 |
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Cardiac markers in left-sided breast cancer patients receiving adjuvant radiotherapy: a prospective study
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Copyright Statement
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
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