Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: An umbrella review.

Amini-Salehi, Ehsan; Mahapatro, Abinash; Korsapati, Rohan Reddy; Korsapati, Aishwarya Reddy; Jain, Shika M; Babaeizad, Ali; Mohammadi, Sina; Rashidian, Pegah; Hashemi, Mohammad; Dave, Tirth; Jamilian, Parsa; Hassanipour, Soheil; Keivanlou, Mohammad-Hossein; Patel, Dhruvan

Abstract

Given the epidemic proportions of type 2 diabetes mellitus (T2DM) globally, it's crucial to comprehensively understand the factors influencing its management. The gut microbiome, known for its influence on various aspects of health, has emerged as a potential regulator of blood pressure in individuals with T2DM. This umbrella review aimed to consolidate the findings of existing meta-analyses investigating the impact of gut microbiome modulation on systolic and diastolic blood pressure in T2DM patients. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, and Web of Science databases from inception to July 2023. Quality assessment was performed using the AMSTAR2 and GRADE checklists. Statistical analyses were conducted using Comprehensive Meta-Analysis (CMA) version 3. A total of 6 meta-analyses meeting the inclusion criteria were included. The results revealed a significant association between microbial modulation and diastolic blood pressure (SMD: -0.133; 95% CI: -0.219 to -0.048; P = 0.002). However, the effect of gut microbial modulation on systolic blood pressure did not reach statistical significance (SMD: -0.077; 95% CI: -0.162 to 0.009; P = 0.078). This study found that modulating the gut microbiome had a statistically significant impact on diastolic blood pressure in individuals with type 2 diabetes mellitus (T2DM). However, no significant effect was observed on systolic blood pressure. While high-quality meta-analyses reported favorable outcomes, caution is warranted due to the low clinical importance, diversity in study populations, and variations in interventions. [Abstract copyright: Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.]

Citation

Amini-Salehi, E., Mahapatro, A., Korsapati, R. R., Korsapati, A. R., Jain, S. M., Babaeizad, A., …Patel, D. (in press). Exploring the relationship between gut microbiome modulation and blood pressure in type 2 diabetes: An umbrella review. Nutrition, Metabolism and Cardiovascular Diseases, https://doi.org/10.1016/j.numecd.2024.05.017

• Journal Article Type: Article
• Acceptance Date: May 13, 2024
• Online Publication Date: May 18, 2024
• Deposit Date: Jul 11, 2024
• Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD
• Print ISSN: 0939-4753
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1016/j.numecd.2024.05.017
• Keywords: Gut microbiota, Blood pressure, Meta-analysis, Synbiotic, Probiotic, Type 2 diabetes, Umbrella review, Prebiotic
• Public URL: https://keele-repository.worktribe.com/output/872045
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S093947532400200X?via%3Dihub