Skip to main content

Research Repository

Advanced Search

The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep

Junges, Leandro; Galvis, Daniel; Winsor, Alice; Treadwell, Grace; Richards, Caroline; Seri, Stefano; Johnson, Samuel; Terry, John R.; Bagshaw, Andrew P.

Authors

Leandro Junges

Daniel Galvis

Alice Winsor

Grace Treadwell

Caroline Richards

Stefano Seri

Samuel Johnson

John R. Terry

Andrew P. Bagshaw



Contributors

Randall Waechter
Editor

Abstract

Epilepsy is one of the most common neurological disorders in children. Diagnosing epilepsy in children can be very challenging, especially as it often coexists with neurodevelopmental conditions like autism and ADHD. Functional brain networks obtained from neuroimaging and electrophysiological data in wakefulness and sleep have been shown to contain signatures of neurological disorders, and can potentially support the diagnosis and management of co-occurring neurodevelopmental conditions. In this work, we use electroencephalography (EEG) recordings from children, in restful wakefulness and sleep, to extract functional connectivity networks in different frequency bands. We explore the relationship of these networks with epilepsy diagnosis and with measures of neurodevelopmental traits, obtained from questionnaires used as screening tools for autism and ADHD. We explore differences in network markers between children with and without epilepsy in wake and sleep, and quantify the correlation between such markers and measures of neurodevelopmental traits. Our findings highlight the importance of considering the interplay between epilepsy and neurodevelopmental traits when exploring network markers of epilepsy.

Citation

Junges, L., Galvis, D., Winsor, A., Treadwell, G., Richards, C., Seri, S., …Bagshaw, A. P. (in press). The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep. PloS one, 19(8), Article e0309243. https://doi.org/10.1371/journal.pone.0309243

Journal Article Type Article
Acceptance Date Aug 7, 2024
Online Publication Date Aug 26, 2024
Deposit Date Sep 2, 2024
Publicly Available Date Sep 2, 2024
Journal PLOS ONE
Print ISSN 1932-6203
Publisher Public Library of Science (PLoS)
Peer Reviewed Peer Reviewed
Volume 19
Issue 8
Article Number e0309243
DOI https://doi.org/10.1371/journal.pone.0309243
Public URL https://keele-repository.worktribe.com/output/890090
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0309243#references

Files

The impact of paediatric epilepsy and co-occurring neurodevelopmental disorders on functional brain networks in wake and sleep (3.9 Mb)
Archive

Licence
https://creativecommons.org/licenses/by/4.0/

Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Downloadable Citations