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Incidence of psoriatic arthritis in a UK primary care psoriasis population.

Rudge, Alex; Brown, Sarah T; Ransom, Myka; Helliwell, Philip S; Packham, Jonathan; Tillett, William; Smith, Theresa; McHugh, Neil John

Authors

Alex Rudge

Sarah T Brown

Myka Ransom

Philip S Helliwell

Jonathan Packham

William Tillett

Theresa Smith

Neil John McHugh



Abstract

To determine the annual incidence of psoriatic arthritis in a UK primary care population with preexisting psoriasis followed prospectively over two years after excluding baseline prevalence of existing disease. TUDOR (Total bUrDen of psORiasis) was a multi-centre, prospective, two-arm parallel-group cluster randomised controlled trial of the early identification of PsA by annual rheumatological assessment (termed Enhanced Surveillance) versus standard care in people with psoriasis identified in primary care. Incidence of psoriatic arthritis is reported at 12- and 24-months using patients from the Enhanced Surveillance arm, which allows the exclusion of patients with prevalent PsA at baseline. Fourteen of 511 participants attending a 12-month screen developed PsA over that interval giving an incidence of 2.74 per 100 patient years (p-yrs) (95% CI: 1.32 to 4.16) and another 7 of 444 participants attending the 24-month visit developed PsA giving an incidence of 1.58 per 100 p-yrs (95% CI: 0.42 to 2.74). The combined incidence over 2 years was 2.20 per 100 p-yrs (95% CI: 1.27 to 3.13). The estimated annual incidence of PsA over a 2-year period was 2.20 per 100 p-yrs, that is in keeping with a higher incidence of PsA than that found when relying on health records alone. Extended follow-up of the TUDOR cohort with accrual of larger numbers of incident cases will allow risk factors for psoriatic arthritis to be explored in more depth.

Citation

Rudge, A., Brown, S. T., Ransom, M., Helliwell, P. S., Packham, J., Tillett, W., …McHugh, N. J. (2024). Incidence of psoriatic arthritis in a UK primary care psoriasis population. The Journal of Rheumatology, 51(9), Article jrheum.2024-0556. https://doi.org/10.3899/jrheum.2024-0556

Journal Article Type Article
Acceptance Date Jul 30, 2024
Online Publication Date Sep 15, 2024
Publication Date Sep 15, 2024
Deposit Date Nov 8, 2024
Journal The Journal of rheumatology
Print ISSN 0315-162X
Electronic ISSN 1499-2752
Publisher Journal of Rheumatology
Peer Reviewed Peer Reviewed
Volume 51
Issue 9
Article Number jrheum.2024-0556
DOI https://doi.org/10.3899/jrheum.2024-0556
Public URL https://keele-repository.worktribe.com/output/923785