All Outputs (45)

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Uche, F. I., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. W. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Planta Medica, 82(S01), https://doi.org/10.1055/s-0036-1596584

Ovarian cancer remains one of the main causes of death in all gynecologic malignancies [1]. Natural products continue to be important sources of clinically approved anti-cancer drugs [2, 3]. Triclisia subcordata Oliv (Menispermeaceae) is a medicinal... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Inhibition of BCKDK increases the sensitivity of ovarian cancer cells to paclitaxel (2016)
Journal Article
Abed, M., & Richardson, A. (2016). Inhibition of BCKDK increases the sensitivity of ovarian cancer cells to paclitaxel. European Journal of Cancer, 69(S1), S20. https://doi.org/10.1016/s0959-8049%2816%2932640-5

Preclinical evaluation of pitavastatin as a treatment for chemotherapy-resistant ovarian cancer (2016)
Journal Article
Robinson, E., Abdullah, M., Jones, S., Menezes, K., Euan, S., Hoskins, C., & Richardson, A. (2016). Preclinical evaluation of pitavastatin as a treatment for chemotherapy-resistant ovarian cancer. European Journal of Cancer, 69(S1), S150. https://doi.org/10.1016/s0959-8049%2816%2933045-3

Bisphosphonates potentiate the activity of pitavastatin against ovarian cancer cells (2016)
Journal Article
Abdullah, M., & Richardson, A. (2016). Bisphosphonates potentiate the activity of pitavastatin against ovarian cancer cells. European Journal of Cancer, 61(S1), S190-S191. https://doi.org/10.1016/s0959-8049%2816%2961674-x

Pitavastatin is a potential treatment for drug-resistant ovarian cancer (2016)
Journal Article
Robinson, E., Jones, S., Menezes, K., Abdullah, M., Stronach, E., Hoskins, C., & Richardson, A. (2016). Pitavastatin is a potential treatment for drug-resistant ovarian cancer. European Journal of Cancer, 61, S192. https://doi.org/10.1016/s0959-8049%2816%2961680-5

Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata (2016)
Journal Article
Uche, F., Drijfhout, F., McCullagh, J., Richardson, A., & Li, W. (2016). Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Li, W., & Richardson, A. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells (2016)
Journal Article
Abed, M., Abdullah, M., & Richardson, A. (2016). Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells. Journal of Ovarian Research, 25 - ?. https://doi.org/10.1186/s13048-016-0234-y

BACKGROUND: BH3 mimetics are a class of drugs that antagonize the Bcl-2 family of apoptosis inhibitors. We have previously shown that these compounds can potentiate the activity of carboplatin against several ovarian cancer cell lines. However, recen... Read More about Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. (2016)
Journal Article
Stamelos, V. A., Fisher, N., Bamrah, H., Voisey, C., Price, J. C., Farrell, W. E., …Richardson, A. (in press). The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization. PloS one, e0150696 - ?. https://doi.org/10.1371/journal.pone.0150696

Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that... Read More about The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization..

Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells (2015)
Journal Article
Kitchen, M. O., Yacqub-Usman, K., Emes, R. D., Richardson, A., Clayton, R. N., & Farrell, W. E. (2015). Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells. Pituitary, 18(5), 674-684. https://doi.org/10.1007/s11102-014-0630-5

Introduction Transgenic mice overexpressing the high mobility group A (HMGA) genes, Hmga1 or Hmga2 develop pituitary tumours and their overexpression is also a frequent finding in human pituitary adenomas. In some cases, increased expression of HMGA... Read More about Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.

Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation (2014)
Journal Article
Robinson, E., Leung, E., Matuszek, A. M., Krogsgaard-Larsen, N., Furkert, D. P., Brimble, M. A., …Reynisson, J. (in press). Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation. MedChemComm, 6(1), 239-246. https://doi.org/10.1039/c4md00420e

Two hit compounds (14 and 62) were identified using virtual high throughput screening (vHTS) inhibiting the autophagy process in A2780 ovarian cancer cells. The expression levels of the LC3-II and p62 autophagy marker proteins were monitored using We... Read More about Virtual screening for novel Atg5–Atg16 complex inhibitors for autophagy modulation.

Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines (2014)
Journal Article
Johnson-Ajinwo, O. R., Richardson, A., & Li, W. (2015). Cytotoxic effects of stem bark extracts and pure compounds from Margaritaria discoidea on human ovarian cancer cell lines. Phytomedicine, 22(1), 1-4. https://doi.org/10.1016/j.phymed.2014.09.008

Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students (2014)
Journal Article
Richardson, A., Curtis, A. D., Moss, G. P., Pearson, R. J., White, S., Rutten, F. J., …Maddock, K. (2014). Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students. American journal of pharmaceutical education, 78(2), 41. https://doi.org/10.5688/ajpe78241

Objective. To implement and assess a task-based learning exercise that prompts pharmacy students to integrate their understanding of different disciplines. Design. Master of pharmacy (MPharm degree) students were provided with simulated informatio... Read More about Simulated Drug Discovery Process to Conduct a Synoptic Assessment of Pharmacy Students.

New strategies for the treatment of ovarian cancer (2014)
Journal Article
Robinson, E., Fisher, N., Stamelos, V., Redman, C., & Richardson, A. (2014). New strategies for the treatment of ovarian cancer. Biochemical Society Transactions, 42(1), 125-129. https://doi.org/10.1042/bst20130203

Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing clinical evaluation, among which angiogenesi... Read More about New strategies for the treatment of ovarian cancer.

Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas (2014)
Journal Article
Jain, H., Richardson, A., Meyer-Hermann, M., & Byrne, H. (2014). Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas. PloS one, e81582 - ?. https://doi.org/10.1371/journal.pone.0081582

Platinum drug-resistance in ovarian cancers mediated by anti-apoptotic proteins such as Bcl-xL is a major factor contributing to the chemotherapeutic resistance of recurrent disease. Consequently, concurrent inhibition of Bcl-xL in combination with c... Read More about Exploiting the synergy between carboplatin and ABT-737 in the treatment of ovarian carcinomas.

The potential for statins in the treatment of ovarian cancer (2013)
Journal Article
Richardson, A., & Robinson, E. (2013). The potential for statins in the treatment of ovarian cancer. International Journal of Molecular Medicine,

Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes. (2013)
Journal Article
Richardson, A., Demoliou-Mason, C., & Barnard, E. A. (2013). Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes. Proceedings of the National Academy of Sciences of the United States of America,

Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. (2013)
Journal Article
Fisher, N., Hilton-Bolt, T., G Edwards, M., J Haxton, K., McKenzie, M., Allin, S. M., & Richardson, A. (2014). Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. ACS medicinal chemistry letters, 5(1), 34-39. https://doi.org/10.1021/ml4003106

Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor..

AUTOTAXIN INHIBITORS AS A POTENTIAL TREATMENT FOR OVARIAN (2013)
Journal Article
Fisher, N., Edwards, M., Allin, S., & Richardson, A. (2013). AUTOTAXIN INHIBITORS AS A POTENTIAL TREATMENT FOR OVARIAN. International Journal of Gynecological Cancer,

Anti-cancer thymoquinone from Nigella sativa (2013)
Journal Article
Li, W., Rosa, J., Siddique, M., Bajana, B., Sulé-Suso, J., & Richardson, A. Anti-cancer thymoquinone from Nigella sativa. Planta Medica, 79(13), https://doi.org/10.1055/s-0033-1351896

Quinones and phenolic compounds are important bioactive natural products in medicinal and dietary plants [1 – 3]. For example, thymoquinone (2-isopropyl-6-methyl-1,4-benzoquinone, TQ) is the main bioactive compound from Nigella sativa (black cumin) (... Read More about Anti-cancer thymoquinone from Nigella sativa.