The potential for statins in the treatment of ovarian cancer
(2013)
Journal Article
Richardson, A., & Robinson, E. (2013). The potential for statins in the treatment of ovarian cancer. International Journal of Molecular Medicine,
All Outputs (8)
Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes. (2013)
Journal Article
Richardson, A., Demoliou-Mason, C., & Barnard, E. A. (2013). Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes. Proceedings of the National Academy of Sciences of the United States of America,
Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. (2013)
Journal Article
Fisher, N., Hilton-Bolt, T., G Edwards, M., J Haxton, K., McKenzie, M., Allin, S. M., & Richardson, A. (2014). Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. ACS medicinal chemistry letters, 5(1), 34-39. https://doi.org/10.1021/ml4003106Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor..
AUTOTAXIN INHIBITORS AS A POTENTIAL TREATMENT FOR OVARIAN (2013)
Journal Article
Fisher, N., Edwards, M., Allin, S., & Richardson, A. (2013). AUTOTAXIN INHIBITORS AS A POTENTIAL TREATMENT FOR OVARIAN. International Journal of Gynecological Cancer,
Anti-cancer thymoquinone from Nigella sativa (2013)
Journal Article
Li, W., Rosa, J., Siddique, M., Bajana, B., Sulé-Suso, J., & Richardson, A. Anti-cancer thymoquinone from Nigella sativa. Planta Medica, 79(13), https://doi.org/10.1055/s-0033-1351896Quinones and phenolic compounds are important bioactive natural products in medicinal and dietary plants [1 – 3]. For example, thymoquinone (2-isopropyl-6-methyl-1,4-benzoquinone, TQ) is the main bioactive compound from Nigella sativa (black cumin) (... Read More about Anti-cancer thymoquinone from Nigella sativa.
Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology (2013)
Journal Article
Maddock, K., & Richardson, A. (2013). Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology. Pharmacy Education, 36 - 39 (4)Background: Pharmacy education requires an understanding of the fundamental principles of molecular pharmacology. Among these, abstract concepts such as affinity, association and dissociation rates and partial agonism may be difficult to demonstrate... Read More about Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology.
Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions (2013)
Journal Article
Richardson, A., Bracegirdle, L., McLachlan, S. I., & Chapman, S. R. (2013). Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions. American journal of pharmaceutical education, 77(1), 11. https://doi.org/10.5688/ajpe77111Objective. To determine whether using 3-dimensional (3D) technology to teach pharmacy students about the molecular basis of the interactions between drugs and their targets is more effective than traditional lecture using 2-dimensional (2D) graphics.... Read More about Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions.
Preclinical evaluation of statins as a treatment for ovarian cancer (2013)
Journal Article
Robinson, E., Nandi, M., Wilkinson, L. L., Arrowsmith, D. M., Curtis, A. D., & Richardson, A. (2013). Preclinical evaluation of statins as a treatment for ovarian cancer. Gynecologic Oncology, 129(2), 417-424. https://doi.org/10.1016/j.ygyno.2013.02.003Objective
To evaluate the potential for statins to treat ovarian cancer.
Methods
The sensitivity of 7 ovarian cancer cell lines to either statins or statins combined with either carboplatin or paclitaxel was assessed using monolayer cultures. Se... Read More about Preclinical evaluation of statins as a treatment for ovarian cancer.