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Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care (2018)
Journal Article
Mallen, Roddy, & Muller. (2018). Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care. Arthritis Care and Research, 1822-1828. https://doi.org/10.1002/acr.23562

Objective
To examine the association between gout severity and socioeconomic status (SES) and gout severity and work absence.

Methods
Postal questionnaires were sent to adult patients who were registered with 20 general practices and who had co... Read More about Gout severity, socioeconomic status and work absence: a cross-sectional study in primary care.

Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017 (2018)
Journal Article
Muller, S., O'Brien, A., Helliwell, T., Hay, C. A., Gilbert, K., Mallen, C. D., & Busby, K. (2018). Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017. Clinical Rheumatology, 3411-3418. https://doi.org/10.1007/s10067-018-4220-1

Polymyalgia rheumatica and giant cell arteritis are relatively common, but under research inflammatory rheumatological conditions. This survey aimed to ascertain the matters in which patients feel they need support with these conditions and appraise... Read More about Support available for and perceived priorities of people with polymyalgia rheumatica and giant cell arteritis: results of the PMRGCAuk members’ survey 2017.

Comorbidities in polymyalgia rheumatica: a systematic review (2018)
Journal Article
Partington, R., Helliwell, T., Muller, S., Abdul Sultan, A., & Mallen, C. (2018). Comorbidities in polymyalgia rheumatica: a systematic review. Arthritis Research and Therapy, 258 -?. https://doi.org/10.1186/s13075-018-1757-y

BACKGROUND AND AIM: Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, causes severe disabil... Read More about Comorbidities in polymyalgia rheumatica: a systematic review.

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article
Mallen, Roddy, Belcher, Clarson, & Muller. (2018). Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study. Arthritis Research and Therapy, 20, Article 243. https://doi.org/10.1186/s13075-018-1746-1

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

The extra-articular impacts of rheumatoid arthritis: moving towards holistic care (2018)
Journal Article
Scott, I., Machin, A., Mallen, C., & Hider, S. (2018). The extra-articular impacts of rheumatoid arthritis: moving towards holistic care. BMC Rheumatology, 2, Article 32. https://doi.org/10.1186/s41927-018-0039-2

Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients' quality of life, and ameliorate the extra-art... Read More about The extra-articular impacts of rheumatoid arthritis: moving towards holistic care.

Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice (2018)
Journal Article
Hider, S., Lawton, S., Muller, S., Helliwell, T., Zwierska, I., Mallen, C., & Richardson, J. (2018). Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice. British Journal of General Practice (BJGP), 68(676), E783-E793. https://doi.org/10.3399/bjgp18X699557

BACKGROUND: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older individuals. Most patients with PMR are diagnosed and managed exclusively in general practice, yet primary care-focused research is lack... Read More about Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice.

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., Edwards, J. J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Objectives
The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate two models... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. (2018)
Journal Article
Mallen. (2018). Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. BMJ Open, e022205 - ?. https://doi.org/10.1136/bmjopen-2018-022205

INTRODUCTION: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness of a physiotherapist-deliver... Read More about Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol..

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., James Edwards, J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Abstract
Objectives The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate t... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study (2018)
Journal Article
Partington, R., Muller, S., Helliwell, T., Mallen, C., & Abdul Sultan, A. (2018). Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study. Annals of the Rheumatic Diseases, 77(12), 1750-1756. https://doi.org/10.1136/annrheumdis-2018-213883

Objective
Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has assessed treatment patterns at a population level... Read More about Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study.

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Mallen. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives
To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination.

Methods
From the Clinical Practice Research Datalink, 32 751 people with auto-i... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.

The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study (2018)
Journal Article
Blagojevic‐Bucknall, M., Mallen, C., Muller, S., Hayward, R., West, S., Choi, H., & Roddy, E. (2019). The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study. Arthritis & Rheumatology, 71(1), 154-160. https://doi.org/10.1002/art.40662

Objective
Obstructive sleep apnea (OSA) is associated with a range of serious comorbidities. This study investigates whether people with OSA are more likely to develop gout than those without OSA in both short and long term.

Methods A matched ret... Read More about The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study.

A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. (2018)
Journal Article
Holden, M., Whittle, R., Waterfield, J., Chesterton, L., Cottrell, E., Quicke, J., & Mallen, C. (2019). A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. Physiotherapy, 105(3), 328 - 337. https://doi.org/10.1016/j.physio.2018.08.003

OBJECTIVE: To explore how physiotherapists currently address analgesic use among patients with hip osteoarthritis, and their beliefs about the acceptability of prescribing for these patients. METHODS: A cross-sectional questionnaire was mailed to 312... Read More about A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis..

The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study (2018)
Journal Article
Helliwell, T., Hider, S., Mallen, C., & Muller, S. (2018). The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study. Primary Health Care Research and Development, https://doi.org/10.1017/S1463423618000543

Aim
To assess the provision of information to, and seeking of, information by patients newly diagnosed with polymyalgia rheumatica (PMR) in primary care.

Background
Polymyalgia rheumatica (PMR) is an inflammatory rheumatological condition of ol... Read More about The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study.

Comorbidity clusters in people with gout: an observational cohort study with linked medical record review (2018)
Journal Article
Mallen, Roddy, Bucknall, & Hider. (2018). Comorbidity clusters in people with gout: an observational cohort study with linked medical record review. Rheumatology, 1358-1363. https://doi.org/10.1002/acr.23562

Objective. To investigate how comorbid conditions cluster in patients with gout in a UK primary care population.

Methods. A cross-sectional study was performed using baseline data from a primary-care-based prospective observational cohort of peop... Read More about Comorbidity clusters in people with gout: an observational cohort study with linked medical record review.

Health-related quality of life in gout in primary care: baseline findings from a cohort study (2018)
Journal Article
Roddy, Mallen, Bucknall, Muller, & Hider. (2018). Health-related quality of life in gout in primary care: baseline findings from a cohort study. Seminars in Arthritis and Rheumatism, 61-69. https://doi.org/10.1016/j.semarthrit.2017.12.005

Objectives: To examine gout-related, comorbid, and sociodemographic characteristics associated with generic and disease-specific health-related quality of life (HRQOL) in gout.

Methods: Adults with gout from 20 general practices were mailed a que... Read More about Health-related quality of life in gout in primary care: baseline findings from a cohort study.

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., …Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies (2018)
Journal Article
Evans, P. L., Prior, J. A., Belcher, J., Mallen, C., Hay, C. A., & Roddy, E. (2018). Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies. Arthritis Research and Therapy, 20, Article 136. https://doi.org/10.1186/s13075-018-1612-1

BACKGROUND: Gout treatment remains suboptimal. Identifying populations at risk of developing gout may provide opportunities for prevention. Our aim was to assess the risk of incident gout associated with obesity, hypertension and diuretic use. METHOD... Read More about Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies.

Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. (2018)
Journal Article
Mallen. (2018). Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care. Pilot and Feasibility Studies, 93 - ?. https://doi.org/10.1186/s40814-018-0288-2

Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was to test the feasibility and e... Read More about Platelet-rich plasma (PRP) therapy for knee arthritis: a feasibility study in primary care..