All Outputs (2)

Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection (2023)
Journal Article
Fraser-Pitt, D., Mercer, D. K., Francis, M., Toledo-Aparicio, D., Smith, D. W., & O'Neil, D. A. (2023). Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and Biophysical Research Communications, 677, 168-181. https://doi.org/10.1016/j.bbrc.2023.08.021

Transient blockade of glycine decarboxylase (GLDC) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory th... Read More about Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection.

Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa (2021)
Journal Article
Fraser-Pitt, D. J., Dolan, S. K., Toledo-Aparicio, D., Hunt, J. G., Smith, D. W., Lacy-Roberts, N., …O’Neil, D. A. (in press). Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa. Frontiers in Cellular and Infection Microbiology, 11, https://doi.org/10.3389/fcimb.2021.718213

Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less v... Read More about Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa.