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miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer (2016)
Journal Article
D'Ippolito, E., Plantamura, I., Bongiovanni, L., Casalini, P., Baroni, S., Piovan, C., Orlandi, R., Gualeni, A. V., Gloghini, A., Rossini, A., Cresta, S., Tessari, A., De Braud, F., Di Leva, G., Tripodo, C., & Iorio, M. V. (2016). miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer. Cancer research, 76(18), 5562 - 5572. https://doi.org/10.1158/0008-5472.CAN-16-0140

Organization of cancer cells into endothelial-like cell-lined structures to support neovascularization and to fuel solid tumors is a hallmark of progression and poor outcome. In triple-negative breast cancer (TNBC), PDGFRß has been identified as a ke... Read More about miR-9 and miR-200 Regulate PDGFRß-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer.

miRNA clusters as therapeutic targets for hormone-resistant breast cancer (2015)
Journal Article
Di Leva, G., Cheung, D. G., & Croce, C. M. (2015). miRNA clusters as therapeutic targets for hormone-resistant breast cancer. Expert Review of Endocrinology and Metabolism, 10(6), 607-617. https://doi.org/10.1586/17446651.2015.1099430

MicroRNAs are small non-coding RNAs that typically inhibit the translation and stability of messenger RNAs, controlling genes involved in cellular processes such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and... Read More about miRNA clusters as therapeutic targets for hormone-resistant breast cancer.

Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo (2015)
Journal Article
Taccioli, C., Garofalo, M., Chen, H., Jiang, Y., Tagliazucchi, G. M., Di Leva, G., Alder, H., Fadda, P., Middleton, J., Smalley, K. J., Selmi, T., Naidu, S., Farber, J. L., Croce, C. M., & Fong, L. Y. (2015). Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo. JNCI: Journal of the National Cancer Institute, 107(11), djv220. https://doi.org/10.1093/jnci/djv220

Background:
Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo.

A set of NF-?B-regulated microRNAs induces acquired TRAIL resistance in lung cancer. (2015)
Journal Article
Jeon, Y.-J., Middleton, J., Kim, T., Laganà, A., Piovan, C., Secchiero, P., Nuovo, G. J., Cui, R., Joshi, P., Romano, G., Di Leva, G., Lee, B.-K., Sun, H.-L., Kim, Y., Fadda, P., Alder, H., Garofalo, M., & Croce, C. M. (2015). A set of NF-?B-regulated microRNAs induces acquired TRAIL resistance in lung cancer. Proceedings of the National Academy of Sciences of the United States of America, 112(26), E3355 - E3364. https://doi.org/10.1073/pnas.1504630112

TRAIL (TNF-related apoptosis-inducing ligand) is a promising anticancer agent that can be potentially used as an alternative or complementary therapy because of its specific antitumor activity. However, TRAIL can also stimulate the proliferation of c... Read More about A set of NF-?B-regulated microRNAs induces acquired TRAIL resistance in lung cancer..

Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer (2015)
Journal Article
Garofalo, M., Jeon, Y.-J., Nuovo, G. J., Middleton, J., Secchiero, P., Joshi, P., Alder, H., Nazaryan, N., Di Leva, G., Romano, G., Crawford, M., Nana-Sinkam, P., & Croce, C. M. Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, 10(6), e0131729. https://doi.org/10.1371/journal.pone.0131729

After the publication of the article, it was noticed that fragments of text in this article overlap with that from previous publications. The overlap in the text relates to the Introduction, Results and Discussion sections, where sentences were repro... Read More about Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.

Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer (2014)
Journal Article
Volinia, S., Nuovo, G., Drusco, A., Costinean, S., Abujarour, R., Desponts, C., Garofalo, M., Baffa, R., Aeqilan, R., Maharry, K., Garzon, M. E. S. R., Di Leva, G., Gasparini, P., Dama, P., Marchesini, J., Galasso, M., Manfrini, M., Zerbinati, C., Corrà, F., Wise, T., …Croce, C. M. (2014). Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer. JNCI: Journal of the National Cancer Institute, 106(12), https://doi.org/10.1093/jnci/dju324

Background
The purpose of this study is to determine whether microRNA for pluripotent stem cells are also expressed in breast cancer and are associated with metastasis and outcome.

Methods
We studied global microRNA profiles during differentiati... Read More about Pluripotent Stem Cell miRNAs and Metastasis in Invasive Breast Cancer.

Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation (2014)
Journal Article
Romano, G., Acunzo, M., Garofalo, M., Di Leva, G., Cascione, L., Zanca, C., Bolon, B., Condorelli, G., & Croce, C. M. (2014). Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation. Proceedings of the National Academy of Sciences of the United States of America, 111(28), 10389-10389. https://doi.org/10.1073/pnas.1410423111

CELL BIOLOGY Correction for “MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation,” by Giulia Romano, Mario Acunzo, Michela Garofalo, Gianpiero Di Leva, Luciano Cascione, Ciro... Read More about Correction for Romano et al., MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non–small-cell lung cancer through BIM down-regulation.

MicroRNA Profiles Discriminate among Colon Cancer Metastasis (2014)
Journal Article
Drusco, A., Nuovo, G. J., Zanesi, N., Di Leva, G., Pichiorri, F., Volinia, S., Fernandez, C., Antenucci, A., Costinean, S., Bottoni, A., Rosito, I. A., Liu, C.-G., Burch, A., Acunzo, M., Pekarsky, Y., Alder, H., Ciardi, A., & Croce, C. M. (in press). MicroRNA Profiles Discriminate among Colon Cancer Metastasis. PloS one, 9(6), Article e96670. https://doi.org/10.1371/journal.pone.0096670

MicroRNAs are being exploited for diagnosis, prognosis and monitoring of cancer and other diseases. Their high tissue specificity and critical role in oncogenesis provide new biomarkers for the diagnosis and classification of cancer as well as predic... Read More about MicroRNA Profiles Discriminate among Colon Cancer Metastasis.

microRNAs as Anti-Cancer Therapy (2014)
Journal Article
Garofalo, M., Di Leva, G., & Croce, C. (2014). microRNAs as Anti-Cancer Therapy. Current Pharmaceutical Design, 20(33), 5328-5335. https://doi.org/10.2174/1381612820666140128211346

MicroRNAs (miRNAs) are endogenously expressed and evolutionarily conserved small non-coding RNAs, which regulate gene expression. Several studies have shown that they are involved in fundamental biological processes, such as proliferation and apoptos... Read More about microRNAs as Anti-Cancer Therapy.

MicroRNAs in Cancer (2014)
Journal Article
Di Leva, G., Garofalo, M., & Croce, C. M. (2014). MicroRNAs in Cancer. Annual Review of Pathology: Mechanisms of Disease, 9(1), 287-314. https://doi.org/10.1146/annurev-pathol-012513-104715

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation... Read More about MicroRNAs in Cancer.

Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri (2014)
Journal Article
Folcik, V. A., Garofalo, M., Coleman, J., Donegan, J. J., Rabbani, E., Suster, S., Nuovo, A., Magro, C. M., Di Leva, G., & Nuovo, G. J. (2014). Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri. Modern Pathology, 27(6), 851-862. https://doi.org/10.1038/modpathol.2013.198

Idiopathic pulmonary fibrosis is a fatal disease without effective therapy or diagnostic test. To investigate a potential role for ?-herpesviruses in this disease, 21 paraffin-embedded lung biopsies from patients diagnosed with idiopathic pulmonary f... Read More about Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri.

Abstract A085: miR-222/221 in aggressive breast cancer (2013)
Presentation / Conference Contribution
Di Leva, G., Piovan, C., Cheung, D., Briskin, D., Kumar, A., Nuovo, G., Fassan, M., Coppola, V., Garofalo, M., & Croce, C. Abstract A085: miR-222/221 in aggressive breast cancer. Presented at AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications, San Diego, CA, USA; October 3-6, 2013

MicroRNAs (miRNAs) are small non coding RNAs that regulate gene expression at post-transcriptional level through translational inhibition and/or degradation of mRNA target genes. Recent evidence points to a widespread role for miRNAs in the initiatio... Read More about Abstract A085: miR-222/221 in aggressive breast cancer.

MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. (2013)
Journal Article
Di Leva, G., Garofalo, M., Jeon, Y.-J., Nuovo, G. J., Middleton, J., Secchiero, P., Joshi, P., Alder, H., Nazaryan, N., Romano, G., Crawford, M., Nana-Sinkam, P., & Croce, C. M. (2013). MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, 8(6), e67581 - ?. https://doi.org/10.1371/journal.pone.0067581

Lung cancer is the leading cause of cancer mortality in the world today. Although some advances in lung cancer therapy have been made, patient survival is still poor. MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human malignan... Read More about MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer..

The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. Frontiers in oncology, 3, 153 - ?. https://doi.org/10.3389/fonc.2013.00153

Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of wom... Read More about The Role of microRNAs in the Tumorigenesis of Ovarian Cancer..

Editorial (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). Editorial. Clinical Biochemistry, 46(10-11), 840-841. https://doi.org/10.1016/j.clinbiochem.2013.05.060

After their discovery in mammalians, more than 20,000 publications about microRNAs have been recorded in Pubmed over the last 11 years. Although some aspects of their biology are still unknown and need some clarifications, it is now clear that microR... Read More about Editorial.

Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. (2013)
Presentation / Conference Contribution
Taccioli, C., Chen, H., Garofalo, M., Jiang, Y., Di Leva, G., Alder, H., Middleton, J., Smalley, K. J., Bottoni, A., Costinean, S., Farber, J. L., Croce, C. M., & Fong, L. Y. Y. Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. Presented at AACR 104th Annual Meeting 2013; Apr 6-10, 2013, Washington, DC, USA

Dietary zinc deficiency (ZD) is implicated in the pathogenesis of human esophageal squamous cell carcinoma (ESCC). microRNA-31 (miR-31) is overexpressed in human ESCC. In the rat a ZD diet promotes esophageal carcinogenesis by inducing cellular proli... Read More about Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats..

Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. (2013)
Presentation / Conference Contribution
Jeon, Y.-J., Nuovo, G. J., Midddleton, J., Joshi, P., Nazaryan, N., Di Leva, G., Romano, G., Crawford, M., Nana-Sinkam, P., Garofalo, M., & Croce, C. M. Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer. Presented at AACR 104th Annual Meeting 2013; Apr 6-10, 2013, Washington, DC, USA

Lung cancer is the most common cause of cancer death worldwide. Despite years of research, the prognosis for patients with lung cancer remains dismal. The most frequent type, non-small cell lung cancer (NSCLC) (85%), shows an overall five year surviv... Read More about Abstract LB-244: MiR-34a/c-dependent PDGFR-α/β reduction inhibits tumorigenesis and sensitizes TRAIL-induced apoptosis in lung cancer..

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. (2013)
Journal Article
Di Leva, G., Piovan, C., Gasparini, P., Ngankeu, A., Taccioli, C., Briskin, D., Cheung, D. G., Bolon, B., Anderlucci, L., Alder, H., Nuovo, G., Li, M., Iorio, M. V., Galasso, M., Ramasamy, S., Marcucci, G., Perrotti, D., Powell, K. A., Bratasz, A., Garofalo, M., …Croce, C. M. (2013). Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLOS genetics, 9(3), Article ARTN e1003311. https://doi.org/10.1371/journal.pgen.1003311

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions have been characterized for some miRNAs, the majority of microRNAs have not b... Read More about Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status..

miRNA profiling of cancer (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). miRNA profiling of cancer. Current Opinion in Genetics and Development, 23(1), 3-11. https://doi.org/10.1016/j.gde.2013.01.004

A steadily growing number of studies have shown that microRNAs have key roles in the regulation of cellular processes and that their dysregulation is essential to keep the malignant phenotype of cancer cells. The distorted and unique expression profi... Read More about miRNA profiling of cancer.