Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach

Alpizar-Sosa, EdubielA.; Zimbres, Flavia M.; Mantilla, Brian S.; Dickie, Emily A.; Wei, Wenbin; Burle-Caldas, Gabriela A.; Filipe, Laura N. S.; Van Bocxlaer, Katrien; Price, Helen P.; Ibarra-Meneses, Ana V.; Beaudry, Francis; Fernandez-Prada, Christopher; Whitfield, Philip D.; Barrett, Michael P.; Denny, Paul W.

doi:10.1021/acsinfecdis.4c00284

All Outputs (3)

Investigating disease awareness of cutaneous leishmaniasis in rural Sri Lanka to inform public health services: a cross-sectional study. (2024)
Journal Article
Gunasekara, S. D., Agampodi, T. C., Weerasinghe, M., Fernando, M. S., Price, H. P., Wickramasinghe, N. D., & Agampodi, S. B. (2024). Investigating disease awareness of cutaneous leishmaniasis in rural Sri Lanka to inform public health services: a cross-sectional study. BMJ Open, 14(11), 1-10. https://doi.org/10.1136/bmjopen-2024-088714

ObjectiveTo assess community awareness of cutaneous leishmaniasis (CL) in a disease-endemic district in Sri Lanka.DesignPopulation-based cross-sectional study.SettingThis study was conducted in selected 158 Grama Niladhari divisions covering all the... Read More about Investigating disease awareness of cutaneous leishmaniasis in rural Sri Lanka to inform public health services: a cross-sectional study..

The economic burden of visceral leishmaniasis and barriers to accessing healthcare in Tigray, North Ethiopia: A field based study (2024)
Journal Article
Tessema, S. B., Hagos, T., Kehasy, G., Paintain, L., Adera, C., Herrero, M., …Mulugeta, A. (in press). The economic burden of visceral leishmaniasis and barriers to accessing healthcare in Tigray, North Ethiopia: A field based study. PLoS Neglected Tropical Diseases, 18(10), Article e0012423. https://doi.org/10.1371/journal.pntd.0012423

Background: Visceral leishmaniasis (VL) is an important public health problem, which mainly affects the poor rural dwelling communities in Low- and Middle-Income Countries. However, little is known about the health and economic burdens of this diseas... Read More about The economic burden of visceral leishmaniasis and barriers to accessing healthcare in Tigray, North Ethiopia: A field based study.

Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach (2024)
Journal Article
Alpizar-Sosa, E., Zimbres, F. M., Mantilla, B. S., Dickie, E. A., Wei, W., Burle-Caldas, G. A., …Denny, P. W. (in press). Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach. ACS Infectious Diseases, 10(8), 2913-2928. https://doi.org/10.1021/acsinfecdis.4c00284

The lack of effective vaccines and the development of resistance to the current treatments highlight the urgent need for new anti-leishmanials. Sphingolipid metabolism has been proposed as a promising source of Leishmania-specific targets as these li... Read More about Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach.