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All Outputs (10)

Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent (2022)
Journal Article
Shephard, M., Merkhan, M., & Forsyth, N. (2022). Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms232113596

The Human Mesenchymal Stem Cell (hMSC) secretome has pleiotropic effects underpinning its therapeutic potential. hMSC serum-free conditioned media (SFCM) contains a variety of cytokines, with previous studies linking a changed secretome composition t... Read More about Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent.

Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway. (2022)
Journal Article
Mostafa, O., Sabry, D., Fouly, M., Ebrahim, N., El-Halim, H., Helal, O., …Salim, R. (2022). Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway. Biomedicine and Pharmacotherapy, 113554 - ?. https://doi.org/10.1016/j.biopha.2022.113554

BACKGROUND: Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus. Mesenchymal stem cells are currently studied as therapeutic strategy for management of DR. Exosomes, considered as a promising cell-free therapy optio... Read More about Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway..

Stem cell-based therapy for human diseases. (2022)
Journal Article
Hoang, D., Pham, P., Bach, T., Ngo, A., Nguyen, Q., Phan, T., …Heke, M. (2022). Stem cell-based therapy for human diseases. Signal Transduction and Targeted Therapy, 272 - ?. https://doi.org/10.1038/s41392-022-01134-4

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells... Read More about Stem cell-based therapy for human diseases..

Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells (2022)
Journal Article
Dogan, F., Aljumaily, R. M. K., Kitchen, M., & Forsyth, N. R. (2022). Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells. International Journal of Molecular Sciences, 23(10), Article 5854. https://doi.org/10.3390/ijms23105854

Pluripotent stem cells (PSC) possess unlimited proliferation, self-renewal, and a differentiation capacity spanning all germ layers. Appropriate culture conditions are important for the maintenance of self-renewal, pluripotency, proliferation, differ... Read More about Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells.