All Outputs (7)

Facile synthesis and biological evaluation of chrysin derivatives (2021)
Journal Article
Omonga, N., Zia, Z., Ghanbour, H., Ragazzon-Smith, A., Foster, H., Hadfield, J., & Ragazzon, P. (2021). Facile synthesis and biological evaluation of chrysin derivatives. Journal of Chemical Research, 1083-1092. https://doi.org/10.1177/17475198211057467

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,... Read More about Facile synthesis and biological evaluation of chrysin derivatives.

Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions (2021)
Journal Article
Barnes, N. G., Ahmed Mal Ullah, A. A., Ragazzon, P. A., Charafi, N., & Hadfield, J. A. (2021). Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions. ChemistrySelect, 6(28), 7082 - 7086. https://doi.org/10.1002/slct.202101960

Combretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions.

Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells (2020)
Journal Article
Al-Sudani, B., Ragazzon-Smith, A. H., Aziz, A., Alansari, R., Ferry, N., Krstic-Demonacos, M., & Ragazzon, P. (2020). Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells. RSC advances, 10(73), 45008-45018. https://doi.org/10.1039/D0RA07857C

It is a challenge to select the right target to treat conditions without affecting non-diseased cells. Cancer belongs to the top 10 causes of death in the world and it remains difficult to treat. Amongst cancer emerging targets, silent information re... Read More about Circular and linear: a tale of aptamer selection for the activation of SIRT1 to induce death in cancer cells.

A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors (2020)
Journal Article
Barnes, N. G., Parker, A. W., Ahmed Mal Ullah, A. A., Ragazzon, P. A., & Hadfield, J. A. (2020). A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors. Bioorganic and Medicinal Chemistry, 28(19), Article 115684. https://doi.org/10.1016/j.bmc.2020.115684

A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiprolife... Read More about A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.

Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents (2019)
Journal Article
McGown, A., Ragazzon-Smith, A., Hadfield, J. A., Potgetier, H., & Ragazzon, P. A. (2019). Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents. Letters in Organic Chemistry, 16(1), 66-75. https://doi.org/10.2174/1570178615666180621094529

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized an... Read More about Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents.

Toxicological and Analytical Assessment of E-Cigarette Refill Components on Airway Epithelia (2016)
Journal Article
Singh, J., Luquet, E., Smith, D. P., Potgieter, H. J., & Ragazzon, P. (2016). Toxicological and Analytical Assessment of E-Cigarette Refill Components on Airway Epithelia. Science Progress, 99(4), 351-398. https://doi.org/10.3184/003685016x14773090197706

There are over 2.6 million users of e-cigarettes in the United Kingdom alone as they have been promoted as a safer alternative to traditional cigarettes. The addition of flavours and aromas has also proven to be popular with younger generations. In t... Read More about Toxicological and Analytical Assessment of E-Cigarette Refill Components on Airway Epithelia.

Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer (2016)
Journal Article
ALMELAH, E., SMITH, D. P. T., MCGOWN, A., AZIZ, A., POTGIETER, H. J., & RAGAZZON, P. (2016). Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer. Anticancer Research, 36(11), 6043-6050. https://doi.org/10.21873/anticanres.11193

Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We developed a novel molecule, 2’, 4’-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteob... Read More about Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer.