Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer

ALMELAH, EMAN; SMITH, DAVID P. T; MCGOWN, ANDREW; AZIZ, ATHAR; POTGIETER, HERMAN J; RAGAZZON, PATRICIA

Abstract

Childhood bone cancer though rare, has very limited treatment choices, with poor survival rates and often involving amputation. We developed a novel molecule, 2’, 4’-dihydroxy-dithion-dibenzoyl-methane and tested it on hepatic, colon, lung and osteoblast cancer cell lines. Thionylation of 2’, 4’- dihydroxydibenzoylmethane led to selective targeting of bone cancer cells, stopping their growth and leading to their death without affecting non-cancerous cells within the bone marrow or other non-malignant cells.

Citation

ALMELAH, E., SMITH, D. P. T., MCGOWN, A., AZIZ, A., POTGIETER, H. J., & RAGAZZON, P. (2016). Dibenzoyl-methane Derivatives as a Potential and Exciting New Therapy for the Treatment of Childhood Bone Cancer. Anticancer Research, 36(11), 6043-6050. https://doi.org/10.21873/anticanres.11193

• Journal Article Type: Article
• Acceptance Date: May 10, 2016
• Online Publication Date: Oct 28, 2016
• Publication Date: Nov 1, 2016
• Deposit Date: Jun 8, 2023
• Journal: Anticancer Research
• Print ISSN: 0250-7005
• Electronic ISSN: 1791-7530
• Publisher: International Institute of Anticancer Research
• Peer Reviewed: Peer Reviewed
• Volume: 36
• Issue: 11
• Pages: 6043-6050
• DOI: https://doi.org/10.21873/anticanres.11193
• Keywords: Cancer Research; Oncology; General Medicine