Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents

McGown, Andrew; Ragazzon-Smith, Abby; Hadfield, John A.; Potgetier, Herman; Ragazzon, Patricia A.

Abstract

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Citation

McGown, A., Ragazzon-Smith, A., Hadfield, J. A., Potgetier, H., & Ragazzon, P. A. (2019). Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents. Letters in Organic Chemistry, 16(1), 66-75. https://doi.org/10.2174/1570178615666180621094529

• Journal Article Type: Article
• Acceptance Date: Jun 14, 2018
• Publication Date: Jan 1, 2019
• Journal: Letters in Organic Chemistry
• Print ISSN: 1570-1786
• Publisher: Bentham Science Publishers
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 1
• Pages: 66-75
• DOI: https://doi.org/10.2174/1570178615666180621094529
• Keywords: Flavonoid; bis-flavonoid; green-chemistry; click-chemistry; microwave-assisted chemistry; anticancer
• Publisher URL: http://doi.org/10.2174/1570178615666180621094529