All Outputs (38)

Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint (2017)
Journal Article
Wright, K. T., Wilson, E., Hulme, C., Kuiper, J. H., Gallacher, P., Richardson, J. B., & Roberts, S. (2017). Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint. International Journal of Experimental Pathology, 97(6), A24

Introduction This study aims to examine the impact of the cartilage harvest procedure on synovial fluid biomarkers at the time of autologous chondrocyte implantation (ACI). Materials and Methods Hyaluronic acid (HA), cartilage oligomeric matrix pr... Read More about Cartilage harvest elevates sCD14 and MMP-3 in the synovial fluid of the autologous chondrocyte implantation (ACI) treated joint.

The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success (2017)
Journal Article
Kuiper, J., Roberts, S., & Wright, K. (2017). The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success. American Journal of Sports Medicine, 1806-1814

Background: Autologous chondrocyte implantation (ACI) is used worldwide in the treatment of cartilage defects in the knee. Several demographic and injury-specific risk factors have been identified that can affect the success of ACI treatment. Howeve... Read More about The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success.

Analysis of cartilage oligomeric matrix protein in synovial fluid, plasma and repair tissue of patients treated with autologous chondrocyte implantation (2016)
Journal Article
McCarthy, H., Wright, K., Williams, J., Gallacher, P., Richardson, J., & Roberts, S. (2016). Analysis of cartilage oligomeric matrix protein in synovial fluid, plasma and repair tissue of patients treated with autologous chondrocyte implantation. International Journal of Experimental Pathology, A11 -A12. https://doi.org/10.1111/iep.12211

Meeting abstract.

Ageing in the musculoskeletal system (2016)
Journal Article
Roberts, S., Colombier, P., Sowman, A., Mennan, C., Rölfing, J. H. D., Guicheux, J., & Edwards, J. R. (2016). Ageing in the musculoskeletal system. Acta orthopaedica, 87(S363), 15- 25. https://doi.org/10.1080/17453674.2016.1244750

The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, an... Read More about Ageing in the musculoskeletal system.

Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. (2016)
Journal Article
Garcia, J., Mennan, C., McCarthy, H. S., Roberts, S., Richardson, J. B., & Wright, K. T. (2016). Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. Stem Cells International, 2016, Article 6969726. https://doi.org/10.1155/2016/6969726

Autologous chondrocyte implantation (ACI) is a cell-based therapy that has been used clinically for over 20 years to treat cartilage injuries more efficiently in order to negate or delay the need for joint replacement surgery. In this time, very litt... Read More about Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat..

Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Wharton’s jelly and bone marrow (2016)
Journal Article
Mennan, C., Brown, S., McCarthy, H., Mavrogonatou, E., Kletsas, D., Garcia, J., …Roberts, S. (2016). Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Wharton’s jelly and bone marrow. FEBS Open Bio, 6(11), 1054-1066. https://doi.org/10.1002/2211-5463.12104

Mesenchymal stromal cells (MSC) can be isolated from several regions of human umbilical cords, including Wharton's jelly (WJ), artery, vein or cord lining. These MSC appear to be immune privileged and are promising candidates for cell therapy. Howeve... Read More about Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Wharton’s jelly and bone marrow.

Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. (2016)
Journal Article
Garcia, J., Wright, K., Roberts, S., Herman Kuiper, J., Mangham, C., Richardson, J., & Mennan, C. (2016). Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Scientific reports, 6, 24295 -?. https://doi.org/10.1038/srep24295

The infrapatellar fat pad (FP) and synovial fluid (SF) in the knee serve as reservoirs of mesenchymal stromal cells (MSCs) with potential therapeutic benefit. We determined the influence of the donor on the phenotype of donor matched FP and SF derive... Read More about Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus..

Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. (2016)
Journal Article
Bhattacharjee, A., McCarthy, H. S., Tins, B., Roberts, S., Kuiper, J. H., Harrison, P. E., & Richardson, J. B. (2016). Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee. American Journal of Sports Medicine, 44(5), 1249 - 1259. https://doi.org/10.1177/0363546516631739

BACKGROUND: Structural and functional outcome of bone graft with first- or second-generation autologous chondrocyte implantation (ACI) in treating cartilage and subchondral bone defect has not been reported previously. PURPOSE: To evaluate the outcom... Read More about Autologous Bone Plug Supplemented With Autologous Chondrocyte Implantation in Osteochondral Defects of the Knee..

Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation (2016)
Journal Article
Wright, K., & Roberts, S. (2016). Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation. Stem Cells International, 5415901 - ?

Much emphasis has been placed recently on the repair of degenerate discs using implanted cells, such as disc cells or bone marrow derived mesenchymal stem cells (MSCs). This study examines the temporal response of bovine and human nucleus pulposus (N... Read More about Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation.

Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest (2015)
Journal Article
McCarthy, H. S., Richardson, J. B., Parker, J. C., & Roberts, S. (2015). Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest. Cartilage, 7(1), 7-15. https://doi.org/10.1177/1947603515607963

Objective To establish if harvesting cartilage to source chondrocytes for autologous chondrocyte implantation (ACI) results in donor site morbidity. Design Twenty-three patients underwent ACI for chondral defects of either the ankle or the hip.... Read More about Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest.

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion (2015)
Journal Article
Roberts, S., Evans, H., Wright, K., van Niekerk, L., Caterson, B., Richardson, J., …Kuiper, J. (2015). ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage, 23(9), 1622-1626. https://doi.org/10.1016/j.joca.2015.05.006

Objective To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease. Design We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with di... Read More about ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.

Wnt-signalling in human articular chondrocytes (2015)
Journal Article
McCarthy, H., Owen, S., & Roberts, S. (2015). Wnt-signalling in human articular chondrocytes. International Journal of Experimental Pathology, 96(2), A27

Introduction Aberrant Wnt-signalling in cartilage results inchondrocyte dedifferentiation, hypertrophy, loss of type II collagen, aggrecan and glycosaminoglycans. Articular chondrocytes experience a pO2 gradient from~6% (surface) to~1% (within deeper... Read More about Wnt-signalling in human articular chondrocytes.

Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. (2014)
Journal Article
Wright, K., & Roberts, S. (2014). Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. Spine Journal, 1722 - 1733. https://doi.org/10.1016/j.spinee.2014.01.021

BACKGROUND CONTEXT: Transplantation of bone marrow cells into spinal cord lesions promotes functional recovery in animal models, and recent clinical trials suggest possible recovery also in humans. The mechanisms responsible for these improvements ar... Read More about Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells..

Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases (2013)
Journal Article
Wright, K. T., Mennan, C., Fox, H., Richardson, J. B., Banerjee, R., & Roberts, S. (2013). Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regenerative Medicine, 8(6), 699 - 709. https://doi.org/10.2217/rme.13.67

AIM: Autologous chondrocyte implantation (ACI) is used worldwide for the treatment of cartilage defects. This study has aimed to assess for the first time the cells that are contained within human ACI repair tissues several years post-treatment. We h... Read More about Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases.

A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation (2013)
Journal Article
McCarthy, H., & Roberts, S. (2013). A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation. Osteoarthritis and Cartilage, 21(12), 2048-2057. https://doi.org/10.1016/j.joca.2013.10.004

Objective In this study, we compare the clinical and histological outcome between periosteum and Chondrogide® during autologous chondrocyte implantation (ACI). Method This study consisted of 88 patients having received ACI in the knee; 33 treate... Read More about A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation.

Increased production of clusterin in biopsies of repair tissue following autologous chondrocyte implantation (2013)
Journal Article
McCarthy, H. S., Malda, J., Richardson, J. B., & Roberts, S. (2013). Increased production of clusterin in biopsies of repair tissue following autologous chondrocyte implantation. Cartilage, 4(3), 227 -238. https://doi.org/10.1177/1947603513477652

OBJECTIVE: To characterize the immunolocalization of clusterin in the repair cartilage of patients having undergone autologous chondrocyte implantation (ACI) and evaluate correlation to clinical outcome. DESIGN: Full-depth core biopsies of repair tis... Read More about Increased production of clusterin in biopsies of repair tissue following autologous chondrocyte implantation.

Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. (2013)
Journal Article
Mennan, C., Wright, K., Bhattacharjee, A., Balain, B., Richardson, J., & Roberts, S. (2013). Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. BioMed Research International, 2013, Article 916136. https://doi.org/10.1155/2013/916136

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal... Read More about Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord..

Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues (2013)
Journal Article
Hanifi, A., McCarthy, H., Roberts, S., & Pleshko, N. (2013). Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues. PloS one, 8(5), Article e64822. https://doi.org/10.1371/journal.pone.0064822

Hyaline cartilage and mechanically inferior fibrocartilage consisting of mixed collagen types are frequently found together in repairing articular cartilage. The present study seeks to develop methodology to identify collagen type and other tissue co... Read More about Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues.