All Outputs (3)

Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility (2019)
Journal Article
Silva, A. I., Haddon, J. E., Ahmed Syed, Y., Trent, S., Lin, T. E., Patel, Y., …Wilkinson, L. S. (2019). Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature communications, 10, Article 3455. https://doi.org/10.1038/s41467-019-11119-7

The biological basis of the increased risk for psychiatric disorders seen in 15q11.2 copy number deletion is unknown. Previous work has shown disturbances in white matter tracts in human carriers of the deletion. Here, in a novel rat model, we recapi... Read More about Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.

Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells (2019)
Journal Article
Trent, S., Hall, J., Connelly, W. M., & Errington, A. C. (2019). Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells. eNeuro, 6(3), ENEURO.0364 - 18.2019. https://doi.org/10.1523/ENEURO.0364-18.2019

Copy number variation (CNV) at chromosomal region 15q11.2 is linked to increased risk of neurodevelopmental disorders including autism and schizophrenia. A significant gene at this locus is cytoplasmic fragile X mental retardation protein (FMRP) inte... Read More about Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells.

Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity (2019)
Journal Article
Clifton, N. E., Trent, S., Thomas, K. L., & Hall, J. (2019). Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity. Molecular Neuropsychiatry, 5(3), 147 - 161. https://doi.org/10.1159/000500267

Alterations in synaptic signaling and plasticity occur during the refinement of neural circuits over the course of development and the adult processes of learning and memory. Synaptic plasticity requires the rearrangement of protein complexes in the... Read More about Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity.