All Outputs (68)

Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS (2006)
Journal Article
Chari, D. M., Gilson, J. M., Franklin, R. J., & Blakemore, W. F. (2006). Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS. Experimental Neurology, 198(1), 145-153. https://doi.org/10.1016/j.expneurol.2005.11.023

Oligodendrocyte lineage cells [oligodendrocytes and their parent cells, the oligodendrocyte progenitor cells (OPCs)] are depleted by X-irradiation and progenitor cell transplantation has been proposed as a therapeutic strategy to counteract radiation... Read More about Oligodendrocyte progenitor cell (OPC) transplantation is unlikely to offer a means of preventing X-irradiation induced damage in the CNS.

Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age (2003)
Journal Article
Chari, D. M., Crang, A. J., & Blakemore, W. F. (2003). Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age. Journal of Neuropathology and Experimental Neurology, 62(9), 908-916. https://doi.org/10.1093/jnen/62.9.908

Rates of remyelination decline with age and this has been attributed to slower recruitment of oligodendrocyte progenitor cells (OPCs) into areas of demyelination and slower differentiation of OPCs into remyelinating oligodendrocytes. When considering... Read More about Decline in Rate of Colonization of Oligodendrocyte Progenitor Cell (OPC)-Depleted Tissue by Adult OPCs with Age.

Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue (2003)
Journal Article
Chari, D., Huang, W., & Blakemore, W. (2003). Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue. Journal of Neuroscience Research, 73(6), 787-793. https://doi.org/10.1002/jnr.10700

We have attempted to extend a previously described rat model of focal oligodendrocyte progenitor cell (OPC) depletion, using 40 Gy X-irradiation (Chari and Blakemore [2002] Glia 37:307–313), to the adult mouse spinal cord, to examine the ability of O... Read More about Dysfunctional oligodendrocyte progenitor cell (OPC) populations may inhibit repopulation of OPC depleted tissue.

New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation (2002)
Journal Article
Chari, D., & Blakemore, W. (2002). New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation. Multiple Sclerosis, 8(4), 271-277. https://doi.org/10.1191/1352458502ms842oa

This review considers aspects of remyelination that require further clarification if successful strategies are to be devised to enhance remyelination in multiple sclerosis (MS). We speculate, based on our understanding of the rate with which oligoden... Read More about New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation.

Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS (2002)
Journal Article
Blakemore, W., Chari, D., Gilson, J., & Crang, A. (2002). Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS. Glia, 38(2), 155-168. https://doi.org/10.1002/glia.10067

Transplantation of myelin-forming glial cells may provide a means of achieving remyelination in situations in which endogenous remyelination fails. For this type of cell therapy to be successful, cells will have to migrate long distances in normal ti... Read More about Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS.

Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells (2002)
Journal Article
Chari, D. M., & Blakemore, W. F. (2002). Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells. Glia, 37(4), 307-313. https://doi.org/10.1002/glia.10038

A widely quoted hypothesis for the failure of remyelination in multiple sclerosis (MS) is the exhaustion of the oligodendrocyte progenitor cell (OPC) pool that is strongly implicated as the source of remyelinating oligodendrocytes in demyelinating le... Read More about Efficient recolonisation of progenitor‐depleted areas of the CNS by adult oligodendrocyte progenitor cells.

Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X‐irradiated compared to normal CNS (2001)
Journal Article
Hinks, G. L., Chari, D. M., T. O'Leary, M., Zhao, C., Keirstead, H. S., Blakemore, W. F., & Franklin, R. J. M. (2001). Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X‐irradiated compared to normal CNS. Neuropathology and Applied Neurobiology, 27(1), 59-67. https://doi.org/10.1046/j.0305-1846.2001.00303.x

Oligodendrocyte progenitors (OPs) survive and migrate following transplantation into adult rat central nervous system (CNS) exposed to high levels of X-irradiation but fail to do so if they are transplanted into normal adult rat CNS. In the context o... Read More about Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X‐irradiated compared to normal CNS.

Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness (1995)
Journal Article
Chari, D. M., Ramesh, V., John, J., & Mohan Kumar, V. (1995). Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness. Indian Journal of Physiology and Pharmacology, 39(3),

Abstract: Intracerebral microinjections of gamma amino butyric acid were Given bilaterally at the medial preoptic area (mPOA) to determine the possible role of this neurotran mitter in the genesis and regulation of leep-wakefulness. GABA (50 Ilg/0.2... Read More about Effect of application of gamma amino butyric acid at the medial preoptic area on sleep-wakefulness.