Skip to main content

Research Repository

Advanced Search

New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation

Chari, DM; Blakemore, WF


WF Blakemore


This review considers aspects of remyelination that require further clarification if successful strategies are to be devised to enhance remyelination in multiple sclerosis (MS). We speculate, based on our understanding of the rate with which oligodendrocyte progenitor cells (OPCs) repopulate OPC-depleted tissue in adult rats, that OPC depletion during the demyelination process could explain why remyelination fails in MS. We show that loss of OPCs in the context of large areas of demyelination would have serious consequences for remyelination as the rates of colonization of tissue by adult OPCs would lead to a situation where the cellular events associated with demyelination become uncoupled from the interaction of OPCs with demyelinated axons. Experimental studies indicate that transplanted neonatal OPCs would be able to repopulate large areas of demyelination with much greater efficiency than endogenous OPCs. This suggests that cell transplantation will have considerable potential to achieve remyelination in situations where the endogenous repair process is failing due to concurrent death of oligodendrocytes and OPCs. However, we suggest that for this approach to be effective, it will be critical that the environment is permissive for remyelination.


Chari, D., & Blakemore, W. (2002). New insights into remyelination failure in multiple sclerosis: implications for glial cell transplantation. Multiple Sclerosis, 8(4), 271-277.

Journal Article Type Article
Acceptance Date Apr 18, 2002
Publication Date Aug 1, 2002
Deposit Date Jun 11, 2024
Journal Multiple Sclerosis
Print ISSN 1352-4585
Electronic ISSN 1352-4585
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 8
Issue 4
Pages 271-277
Keywords multiple sclerosis; oligodendrocyte progenitor cells; remyelination; transplantation
Public URL