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Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases (2020)
Journal Article
Mangas-Sanchez, J., Sharma, M., Cosgrove, S. C., Ramsden, J. I., Marshall, J. R., Thorpe, T. W., …Turner, N. J. (in press). Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chemical Science, 11(19), 5052-5057. https://doi.org/10.1039/d0sc02253e

Chiral primary amines are important intermediates in the synthesis of pharmaceutical compounds. Fungal reductive aminases (RedAms) are NADPH-dependent dehydrogenases that catalyse reductive amination of a range of ketones with short-chain primary ami... Read More about Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases.

Developing the Scientific Reporting Skills of Chemistry Students (2020)
Book Chapter
McGarvey, D., Beaumont, K., Capel, N., Hancock, L., Haxton, K., Hollamby, M., …Plana, D. (2020). Developing the Scientific Reporting Skills of Chemistry Students. In On Your Marks: Learner-Focused Feedback Practices and Feedback Literacy. Advance HE

Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline (2020)
Journal Article
Goodwin, J. W., Kruger, P. E., & Hawes, C. S. (2020). Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline. Journal of Coordination Chemistry, 74(1-3), 341-360. https://doi.org/10.1080/00958972.2020.1868041

In this work we report the coordination chemistry of a rigid heterotopic ligand 1H-pyrazolo[4,3-h]quinoline HL1 in copper(II) and zinc(II) complexes for the first time, and examine both the structural properties and solution-phase behaviour of these... Read More about Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline.

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani  , I., Rudd  , T. R., Elli  , S., Gandhi  , N. S., …Skidmore   , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Is GW190521 the merger of black holes from the first stellar generations? (2020)
Journal Article
Farrell, E., Groh, J. H., Hirschi, R., Murphy, L., Kaiser, E., Ekström, S., …Meynet, G. (2021). Is GW190521 the merger of black holes from the first stellar generations?. Monthly Notices of the Royal Astronomical Society, 502(1), L40-L44. https://doi.org/10.1093/mnrasl/slaa196

GW190521 challenges our understanding of the late-stage evolution of massive stars and the effects of the pair-instability in particular. We discuss the possibility that stars at low or zero metallicity could retain most of their hydrogen envelope un... Read More about Is GW190521 the merger of black holes from the first stellar generations?.

A ß?Cephei pulsator and a changing orbital inclination in the high-mass eclipsing binary system VV?Orionis (2020)
Journal Article
Southworth, J., Bowman, D. M., & Pavlovski, K. (2021). A ß?Cephei pulsator and a changing orbital inclination in the high-mass eclipsing binary system VV?Orionis. Monthly Notices of the Royal Astronomical Society: Letters, 501(1), L65 - L70. https://doi.org/10.1093/mnrasl/slaa197

We present an analysis of the high-mass eclipsing binary system VV?Ori based on photometry from the TESS satellite. The primary star (B1?V, 9.5?M??) shows ß?Cephei pulsations and the secondary (B7?V, 3.8?M??) is possibly a slowly pulsating B star. We... Read More about A ß?Cephei pulsator and a changing orbital inclination in the high-mass eclipsing binary system VV?Orionis.

The CARMENES search for exoplanets around M dwarfs: LP 714-47 b (TOI 442.01): populating the Neptune desert (2020)
Journal Article
Hellier. (2020). The CARMENES search for exoplanets around M dwarfs: LP 714-47 b (TOI 442.01): populating the Neptune desert. Astronomy and Astrophysics, https://doi.org/10.1051/0004-6361/202038016

We report the discovery of a Neptune-like planet (LP 714-47 b, P = 4.05204 d, mb = 30.8 ± 1.5M?, Rb = 4.7 ± 0.3 R?) located in the “hot Neptune desert”. Confirmation of the TESS Object of Interest (TOI 442.01) was achieved with radial-velocity follow... Read More about The CARMENES search for exoplanets around M dwarfs: LP 714-47 b (TOI 442.01): populating the Neptune desert.

Grids of stellar models with rotation: V. Models from 1.7 to 120 Msun at zero metallicity (2020)
Journal Article
Murphy, L. J., Groh, J. H., Ekström, S., Meynet, G., Pezzotti, C., Georgy, C., …Martinet, S. (2021). Grids of stellar models with rotation: V. Models from 1.7 to 120 Msun at zero metallicity. Monthly Notices of the Royal Astronomical Society, 501(2), 2745-2763. https://doi.org/10.1093/mnras/staa3803

Understanding the nature of the first stars is key to understanding the early universe. With new facilities such as JWST we may soon have the first observations of the earliest stellar populations, but to understand these observations we require deta... Read More about Grids of stellar models with rotation: V. Models from 1.7 to 120 Msun at zero metallicity.

Two Young Planetary Systems around Field Stars with Ages between 20 and 320 Myr from TESS (2020)
Journal Article
Hellier. (2020). Two Young Planetary Systems around Field Stars with Ages between 20 and 320 Myr from TESS. Astronomical Journal, 2 - 2. https://doi.org/10.3847/1538-3881/abba22

Planets around young stars trace the early evolution of planetary systems. We report the discovery and validation of two planetary systems with ages ?300 Myr from observations by the Transiting Exoplanet Survey Satellite (TESS). The Myr old G star TO... Read More about Two Young Planetary Systems around Field Stars with Ages between 20 and 320 Myr from TESS.

Rediscussion Of Eclipsing Binaries. Paper I: The Totally-eclipsing B-type System Zeta Phoenicis (2020)
Journal Article
Taylor. (2020). Rediscussion Of Eclipsing Binaries. Paper I: The Totally-eclipsing B-type System Zeta Phoenicis. Observatory, 140, 247 -262

zeta Phe is a bright binary system containing B6 V and B8 V stars. It has deep total and annular eclipses, a slightly eccentric orbit with a period of I-d.669, apsidal motion, and a third body on a wider orbit. The Transiting Exoplanet Survey Satelli... Read More about Rediscussion Of Eclipsing Binaries. Paper I: The Totally-eclipsing B-type System Zeta Phoenicis.

Computer modelling of Bi12SiO20 and Bi4Si3O12: Intrinsic defects and rare earth ion incorporation (2020)
Journal Article
Jackson. (2020). Computer modelling of Bi12SiO20 and Bi4Si3O12: Intrinsic defects and rare earth ion incorporation. Journal of Solid State Chemistry, https://doi.org/10.1016/j.jssc.2020.121608

Defect properties of Bi12SiO12 and Bi4Si3O12 compounds were investigated using atomistic computer modelling techniques based on energy minimisation. Interatomic potentials obtained by empirical fitting reproduce the lattice parameters for both materi... Read More about Computer modelling of Bi12SiO20 and Bi4Si3O12: Intrinsic defects and rare earth ion incorporation.

Infrared spectroscopy of CK Vulpeculae: revealing a remarkably powerful blast from the past (2020)
Journal Article
(2020). Infrared spectroscopy of CK Vulpeculae: revealing a remarkably powerful blast from the past. Astrophysical Journal Letters, https://doi.org/10.3847/2041-8213/abc885

CK Vulpeculae (CK Vul), which erupted in AD 1670-71, was long considered to be a nova outburst; however, recent observations have required that alternative scenarios be considered. Long-slit infrared spectroscopy of a forbidden line of iron reported... Read More about Infrared spectroscopy of CK Vulpeculae: revealing a remarkably powerful blast from the past.

Statistical Signatures of Nanoflare Activity. II. A Nanoflare Explanation for Periodic Brightenings in Flare Stars Observed by NGTS (2020)
Journal Article
(2020). Statistical Signatures of Nanoflare Activity. II. A Nanoflare Explanation for Periodic Brightenings in Flare Stars Observed by NGTS. Astrophysical Journal, 1-18. https://doi.org/10.3847/1538-4357/abbfa8

Several studies have documented periodic and quasi-periodic signals from the time series of dMe flare stars and other stellar sources. Such periodic signals, observed within quiescent phases (i.e., devoid of larger-scale microflare or flare activity)... Read More about Statistical Signatures of Nanoflare Activity. II. A Nanoflare Explanation for Periodic Brightenings in Flare Stars Observed by NGTS.

Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes (2020)
Journal Article
Beswick, L., Dimitriou, E., Ahmadipour, S., Zafar, A., Rejzek, M., Reynisson, J., …Miller, G. (2020). Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes. ACS chemical biology, 15(12), 3086–3092. https://doi.org/10.1021/acschembio.0c00426

Sufferers of cystic fibrosis are at extremely high risk for contracting chronic lung infections. Over their lifetime, one bacterial strain in particular, Pseudomonas aeruginosa, becomes the dominant pathogen. Bacterial strains incur loss-of-function... Read More about Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes.

Laboratory Safety for Undergraduate Chemistry Students (2020)
Book Chapter
Hancock, L. M., Hollamby, M. J., & Jones, G. R. (2020). Laboratory Safety for Undergraduate Chemistry Students. In Challenges for Health and Safety in Higher Education and Research Organisations (111-141). Royal Society of Chemistry. https://doi.org/10.1039/9781839162497-00111

From our perspective as chemistry lecturers our primary goal is to graduate trained chemists who can enter into employment or research degrees and can operate safely within a laboratory; the sort of chemist whose first thought is ‘how do I carry out... Read More about Laboratory Safety for Undergraduate Chemistry Students.

New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites (2020)
Journal Article
Arnold, E., Keeble, D., Greenwood, C., & Rogers, K. (2020). New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites. Scientific reports, 10, Article 19597. https://doi.org/10.1038/s41598-020-73200-2

Biogenic and synthetic hydroxyapatites are confounding materials whose properties remain uncertain, even after years of study. Pair distribution function (PDF) analysis was applied to hydroxyapatites in the 1970’s and 1980’s, but this area of researc... Read More about New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites.

Orbital and physical parameters of eclipsing binaries from the ASAS catalogue – XI. CHIRON investigation of long-period binaries* (2020)
Journal Article
Hellier. (2020). Orbital and physical parameters of eclipsing binaries from the ASAS catalogue – XI. CHIRON investigation of long-period binaries*. Monthly Notices of the Royal Astronomical Society, https://doi.org/10.1093/mnras/staa3488

We present the results of a spectroscopic campaign on eclipsing binaries with long orbital period (P = 20 - 75 d) carried out with the CHIRON spectrograph. Physical and orbital solutions for seven systems were derived from the V-band, and I-band ASAS... Read More about Orbital and physical parameters of eclipsing binaries from the ASAS catalogue – XI. CHIRON investigation of long-period binaries*.

The hot dayside and asymmetric transit of WASP-189 b seen by CHEOPS (2020)
Journal Article
Maxted. (2020). The hot dayside and asymmetric transit of WASP-189 b seen by CHEOPS. Astronomy and Astrophysics, https://doi.org/10.1051/0004-6361/202038677

The CHEOPS space mission dedicated to exoplanet follow-up was launched in December 2019, equipped with the capacity to perform photometric measurements at the 20 ppm level. As CHEOPS carries out its observations in a broad optical passband, it can pr... Read More about The hot dayside and asymmetric transit of WASP-189 b seen by CHEOPS.

Is it time for biocatalysis in fragment-based drug discovery? (2020)
Journal Article
Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature... Read More about Is it time for biocatalysis in fragment-based drug discovery?.