All Outputs (2)

An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria (2022)
Thesis
Ogbolosingha, A. J. (2022). An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria. (Thesis). Keele University

Cerebral malaria (CM) is the most life-threatening complication of Plasmodium falciparum (Pf) infection. A key hallmark of CM is the sequestration of Pf infected red blood cells (PRBC) to the human brain endothelial cells (HBEC) of the blood brain ba... Read More about An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria.

The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum (2020)
Thesis
Anagu, L. O. (2020). The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum. (Thesis). Keele University

Plasmodium falciparum encodes a family of key virulence genes called var genes. These encode adhesive proteins that are expressed on infected erythrocytes in a mutually exclusive manner. The parasite’s sirtuins have been implicated in epigenetic sele... Read More about The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum.