Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods.

doi:10.1186/s13071-020-04403-9

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae (2020)
Journal Article
Simoni, A., Hammond, A. M., Beaghton, A. K., Galizi, R., Taxiarchi, C., Kyrou, K., …Crisanti, A. (2020). A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. Nature Biotechnology, https://doi.org/10.1038/s41587-020-0508-1

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce uni... Read More about A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae.

Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum) (2020)
Journal Article
(2020). Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum). Conservation Physiology, coaa117 - ?. https://doi.org/10.1093/conphys/coaa117

The white rhinoceros (Ceratotherium simum) is experiencing unsustainable poaching losses fuelled by a demand for horn. Increasingly, private and state reserves are dehorning their rhinoceros populations in an attempt to reduce poaching pressure. Rhin... Read More about Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum).

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani  , I., Rudd  , T. R., Elli  , S., Gandhi  , N. S., …Skidmore  , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. (2020)
Journal Article
Buckley, J., Riddell, M., Mellor, D., Bracken, R., Poirier, P., LaGerche, A., & Ross, M. (2020). Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2020-102446

Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are significant precursors and comorbidities to cardiovascular disease and prevalence of both types is still rising globally. Currently,~25% of participants (and rising) attending cardiac rehabilitat... Read More about Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences..

Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean (Phaseolus vulgaris) Plants Through a Combination of Volatile and Surface Cues (2020)
Journal Article
Mutuku, J., Cunniffe, N., Pickett, J., Carr, J., Woodcock, C., Gilligan, C., …Bruce, T. (2020). Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean (Phaseolus vulgaris) Plants Through a Combination of Volatile and Surface Cues. Frontiers in Plant Science, 11, Article 613772. https://doi.org/10.3389/fpls.2020.613772

Bean common mosaic virus (BCMV), bean common mosaic necrosis virus (BCMNV), and cucumber mosaic virus (CMV) are important pathogens of common bean (Phaseolus vulgaris), a crop vital for food security in sub-Saharan Africa. These viruses are vectored... Read More about Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean (Phaseolus vulgaris) Plants Through a Combination of Volatile and Surface Cues.

Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan (2020)
Journal Article
Siam, H., Samy, A., Mohamed, W., Khalid, F., Gumaa, S., Mboera, L., …Ahmed, A. (2020). Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan. PLoS Neglected Tropical Diseases, e0008918 - e0008918. https://doi.org/10.1371/journal.pntd.0008918

Dengue is a rapidly growing public health threat in Kassala state, eastern Sudan. The objective of this study was to determine the seroprevalence, entomological transmission indices, and socioeconomic risk factors associated with dengue in this regio... Read More about Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan.

Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis (2020)
Journal Article
Bhuiyan, M., Stiboy, E., Hassan, M., Chan, M., Islam, M., Haider, N., …Homaira, N. (2021). Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis. Vaccine, 39(4), 667 - 677. https://doi.org/10.1016/j.vaccine.2020.11.078

Introduction Emerging evidence suggests young children are at greater risk of COVID-19 infection than initially predicted. However, a comprehensive understanding of epidemiology of COVID-19 infection in young children under five years, the most at-r... Read More about Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis.

Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications (2020)
Journal Article
Abedin, N., Alshehri, A. H. A., Almughrbi, A. M., Moore, O., Alyza, S., Rusbridge, E. K., …Fitzpatrick, A. J. (2020). Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications. Polyhedron, 190, 114755. https://doi.org/10.1016/j.poly.2020.114755

A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(HAmpy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallogr... Read More about Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications.

Insecticide Resistance Profiling of Anopheles coluzzii and Anopheles gambiae Populations in the Southern Senegal: Role of Target Sites and Metabolic Resistance Mechanisms. (2020)
Journal Article
(2020). Insecticide Resistance Profiling of Anopheles coluzzii and Anopheles gambiae Populations in the Southern Senegal: Role of Target Sites and Metabolic Resistance Mechanisms. Genes, https://doi.org/10.3390/genes11121403

The emergence and spread of insecticide resistance among the main malaria vectors is threatening the effectiveness of vector control interventions in Senegal. The main drivers of this resistance in the Anopheles gambiae complex (e.g., An. gambiae and... Read More about Insecticide Resistance Profiling of Anopheles coluzzii and Anopheles gambiae Populations in the Southern Senegal: Role of Target Sites and Metabolic Resistance Mechanisms..

Effects of blood parasite infections on spatiotemporal migration patterns and activity budgets in a long-distance migratory passerine (2020)
Journal Article
Emmenegger, T., Bensch, S., Hahn, S., Kishkinev, D., Procházka, P., Zehtindjiev, P., & Bauer, S. (2020). Effects of blood parasite infections on spatiotemporal migration patterns and activity budgets in a long-distance migratory passerine. Ecology and Evolution, https://doi.org/10.1002/ece3.7030

How blood parasite infections influence the migration of hosts remains a lively debated issue as past studies found negative, positive or no response to infections. This particularly applies to small birds, for which monitoring of detailed migration... Read More about Effects of blood parasite infections on spatiotemporal migration patterns and activity budgets in a long-distance migratory passerine.

Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans. (2020)
Journal Article
Hyatt, J. G., Prévost, S., Devos, J. M., Mycroft-West, C. J., Skidmore, M. A., & Winter, A. (2020). Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans. Pathogens an international, open access journal of pathogens and pathogen-host interactions, 9(11), Article 935. https://doi.org/10.3390/pathogens9110935

Dengue fever is a rapidly emerging vector-borne viral disease with a growing global burden of approximately 390 million new infections per annum. The Dengue virus (DENV) is a flavivirus spread by female mosquitos of the aedes genus, but the mechanism... Read More about Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans..

Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2 (2020)
Journal Article
Andrade De Lima, M., Skidmore, M., Khanim, F., & Richardson, A. (2020). Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2. Biochemical and Biophysical Research Communications, 534, 485--490. https://doi.org/10.1016/j.bbrc.2020.11.055

To identify drugs that could potentially be used to treat infection with SARS-CoV-2, a high throughput 384-well assay was developed to measure the binding of the receptor binding domain (RBD) of the viral S1 protein to its main receptor, angiotensin... Read More about Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2.

Artificial neural networks for monitoring network optimisation—a practical example using a national insect survey (2020)
Journal Article
Bourhis, Y., Bell, J., Bosch, F., V. D., & Milne, A. (2021). Artificial neural networks for monitoring network optimisation—a practical example using a national insect survey. Environmental Modelling and Software, 135, Article 104925. https://doi.org/10.1016/j.envsoft.2020.104925

Monitoring networks are improved by additional sensors. Optimal configurations of sensors give better representations of the process of interest, maximising its exploration while minimising the need for costly infrastructure. By modelling the monitor... Read More about Artificial neural networks for monitoring network optimisation—a practical example using a national insect survey.

Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen (2020)
Journal Article
Gavrin, A., Rey, T., Torode, T. A., Toulotte, J., Chatterjee, A., Louis Kaplan, J., …Schornack, S. (2020). Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen. Current Biology, 4165 - 4176.e5. https://doi.org/10.1016/j.cub.2020.08.011

The cell wall is the primary interface between plant cells and their immediate environment and must balance multiple functionalities, including the regulation of growth, the entry of beneficial microbes, and protection against pathogens. Here, we dem... Read More about Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen.

How is silicic acid transported in plants? (2020)
Journal Article
(2020). How is silicic acid transported in plants?. Silicon, 2641 - 2645. https://doi.org/10.1007/s12633-019-00360-w

Plants accumulate silicon in their tissues as amorphous silica. The form of silicon taken up by plants is silicic acid, a neutral molecule that passes through membrane channels with water. After seminal work on rice identified an aquaporin that appea... Read More about How is silicic acid transported in plants?.

Assessment of the ecologically dependent post-zygotic isolation between Anopheles coluzzii and Anopheles gambiae. (2020)
Journal Article
(2020). Assessment of the ecologically dependent post-zygotic isolation between Anopheles coluzzii and Anopheles gambiae. PloS one, e0240625 - ?. https://doi.org/10.1371/journal.pone.0240625

Within the Anopheles gambiae complex, the sibling species An. coluzzii and An. gambiae are undergoing sympatric speciation. These species are characterized by rare hybrids in most of their geographical distribution. A strong assortative mating mediat... Read More about Assessment of the ecologically dependent post-zygotic isolation between Anopheles coluzzii and Anopheles gambiae..

Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics (2020)
Journal Article
Galizi, R., Duncan, J. N., Rostain, W., Quinn, C. M., Storch, M., Kushwaha, M., & Jaramillo, A. (2020). Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics. The CRISPR Journal, 398 - 408. https://doi.org/10.1089/crispr.2020.0029

CRISPR guide RNAs (gRNAs) can be programmed with relative ease to allow the genetic editing of nearly any DNA or RNA sequence. Here, we propose novel molecular architectures to achieve RNA-dependent modulation of CRISPR activity in response to specif... Read More about Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics.

Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies (2020)
Journal Article
Matos Rocha, E., de Melo Katak, R., Campos de Oliveira, J., da Silva Araujo, M., Cechetto Carlos, B., Galizi, R., …A. Souza-Neto, J. (2020). Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies. Tropical Medicine and Infectious Disease, 161. https://doi.org/10.3390/tropicalmed5040161

In Brazil, malaria transmission is mostly confined to the Amazon, where substantial progress has been achieved towards disease control in the past decade. Vector control has been historically considered a fundamental part of the main malaria control... Read More about Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies.

The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy. (2020)
Journal Article
Samia, P., Williams, F., Taylor, S., Lindoewood, R., Barton, C., & Buckley, J. (2020). The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy. Disability and Rehabilitation: Assistive Technology, 1 - 11. https://doi.org/10.1080/17483107.2020.1830442

PURPOSE: Appropriate paper-based technology (APT) is used to provide postural support for children with cerebral palsy (CP) in low-resourced settings. This pilot study aimed to evaluate the impact of APT on the children's and families' lives. MATERIA... Read More about The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy..

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods. (2020)
Journal Article
(2020). Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods. Parasites and Vectors, 516 - ?. https://doi.org/10.1186/s13071-020-04403-9

BACKGROUND: One of the promising current approaches to curb malaria lies in genetic vector control, the implementation of which will require an improved understanding of the movement of genetic constructs among mosquito populations. To predict potent... Read More about Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods..

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