All Outputs (857)

ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis (2021)
Journal Article
Meneghetti, M., Deboni, P., Palomino, C., Braga, L., Cavalheiro, R., Viana, G., …Andrade De Lima, M. (2021). ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis. Carbohydrate Polymers, 117477--117477. https://doi.org/10.1016/j.carbpol.2020.117477

The cell surface and extracellular matrix polysaccharide, heparan sulfate (HS) conveys chemical information to control crucial biological processes. HS chains are synthesized in a non-template driven process mainly in the Golgi apparatus, involving a... Read More about ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis.

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance (2021)
Journal Article
Hammond, A., Karlsson, X., Morianou, I., Kyrou, K., Beaghton, A., Gribble, M., …Nolan, T. (2021). Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance. PLoS Genetics, e1009321 - ?. https://doi.org/10.1371/journal.pgen.1009321

Homing-based gene drives use a germline source of nuclease to copy themselves at specific target sites in a genome and bias their inheritance. Such gene drives can be designed to spread and deliberately suppress populations of malaria mosquitoes by i... Read More about Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance.

Improved BioGents® Sentinel trap with heat (BGSH) for outdoor collections of Anopheline species in Burkina Faso and Mali, West Africa (2021)
Journal Article
(2021). Improved BioGents® Sentinel trap with heat (BGSH) for outdoor collections of Anopheline species in Burkina Faso and Mali, West Africa. Parasites and Vectors, 82 -?. https://doi.org/10.1186/s13071-020-04527-y

BACKGROUND: Since the late 1990s, malaria control programmes have relied extensively on mass bednet distribution and indoor residual spraying. Both interventions use pesticides and target mosquitoes coming indoors either to feed or to rest. Unfortuna... Read More about Improved BioGents® Sentinel trap with heat (BGSH) for outdoor collections of Anopheline species in Burkina Faso and Mali, West Africa.

Identification of Risk Factors Associated with Resistant Escherichia coli Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross Sectional Study (2021)
Journal Article
Osman, A., Elmi, S., Simons, D., Elton, L., Haider, N., Abdel Hamid, M., …Kock, R. (2021). Identification of Risk Factors Associated with Resistant Escherichia coli Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross Sectional Study. Antibiotics, 117 - 117. https://doi.org/10.3390/antibiotics10020117

Antimicrobial resistance is of concern to global health security worldwide. We aimed to identify the prevalence, resistance patterns, and risk factors associated with Escherichia coli (E. coli) resistance from poultry farms in Kelantan, Terengganu, a... Read More about Identification of Risk Factors Associated with Resistant Escherichia coli Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross Sectional Study.

A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control (2021)
Journal Article
(2021). A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control. Frontiers in Immunology, 601895 - ?. https://doi.org/10.3389/fimmu.2020.601895

Complement Factor H (CFH), with 20 short complement regulator (SCR) domains, regulates the alternative pathway of complement in part through the interaction of its C-terminal SCR-19 and SCR-20 domains with host cell-bound C3b and anionic oligosacchar... Read More about A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control.

MEDI: Macronutrient Extraction and Determination from invertebrates, a rapid, cheap and streamlined protocol (2021)
Journal Article
Cuff, J. P., Wilder, S. M., Tercel, M. P., Hunt, R., Oluwaseun, S., Morley, P. S., …Müller, C. T. (2021). MEDI: Macronutrient Extraction and Determination from invertebrates, a rapid, cheap and streamlined protocol. Methods in Ecology and Evolution, 12(4), 593-601. https://doi.org/10.1111/2041-210X.13551

Macronutrients, comprising carbohydrates, proteins and lipids, underpin many ecological processes, but their quantification in ecological studies is often inaccurate and laborious, requiring large investments of time and bulk samples, which make indi... Read More about MEDI: Macronutrient Extraction and Determination from invertebrates, a rapid, cheap and streamlined protocol.

Transient ultrasound stimulation has lasting effects on neuronal excitability (2021)
Journal Article
Clennell, B., Steward, T. G., Elley, M., Shin, E., Weston, M., Drinkwater, B. W., & Whitcomb, D. J. (2021). Transient ultrasound stimulation has lasting effects on neuronal excitability. Brain Stimulation, 14(2), 217-225. https://doi.org/10.1016/j.brs.2021.01.003

Background Transcranial ultrasound stimulation can acutely modulate brain activity, but the lasting effects on neurons are unknown. Objective To assess the excitability profile of neurons in the hours following transient ultrasound stimulation.... Read More about Transient ultrasound stimulation has lasting effects on neuronal excitability.

Biological Flora of the British Isles: Crataegus laevigata (2021)
Journal Article
Thomas, P. A., Leski, T., La Porta, N., Dering, M., & Iszkulo, G. (2021). Biological Flora of the British Isles: Crataegus laevigata. Journal of Ecology, 109(1), 572-596. https://doi.org/10.1111/1365-2745.13541

This account presents information on all aspects of the biology of Crataegus laevigata (Poir.) DC (Midland hawthorn) (C. oxyacanthoides Thuill.) that are relevant to understanding its ecological characteristics and behaviour. The main topics are pres... Read More about Biological Flora of the British Isles: Crataegus laevigata.

Zucchini Plants Alter Gene Expression and Emission of (E)-ß-Caryophyllene Following Aphis gossypii Infestation (2021)
Journal Article
Vitiello, A., Rao, R., Giorgini, M., Molisso, D., Digilio, M., Corrado, G., …D'Agostino, N. (2021). Zucchini Plants Alter Gene Expression and Emission of (E)-ß-Caryophyllene Following Aphis gossypii Infestation. Frontiers in Plant Science, 592603 - ?. https://doi.org/10.3389/fpls.2020.592603

Zucchini (Cucurbita pepo L.) is widely cultivated in temperate regions. One of the major production challenges is the damage caused by Aphis gossypii (Homoptera: Aphididae), a polyphagous aphid, which can negatively affect its host plant, both direct... Read More about Zucchini Plants Alter Gene Expression and Emission of (E)-ß-Caryophyllene Following Aphis gossypii Infestation.

Neuroprotective effect of heparin Trisulfated disaccharide on ischemic stroke (2021)
Journal Article
Chiarantin, G. M. D., Delgado-Garcia, L. M., Zamproni, L. N., Lima, M. A., Nader, H. B., Tersariol, I. L. S., & Porcionatto, M. (2021). Neuroprotective effect of heparin Trisulfated disaccharide on ischemic stroke. Glycoconjugate Journal, 38(1), 35--43. https://doi.org/10.1007/s10719-020-09966-4

Cells undergoing hypoxia experience intense cytoplasmic calcium (Ca2+) overload. High concentrations of intracellular calcium ([Ca2+]i) can trigger cell death in the neural tissue, a hallmark of stroke. Neural Ca2+ homeostasis involves regulation by... Read More about Neuroprotective effect of heparin Trisulfated disaccharide on ischemic stroke.

Laboratory and microcosm experiments reveal contrasted adaptive responses to ammonia and water mineralisation in aquatic stages of the sibling species Anopheles gambiae (sensu stricto) and Anopheles coluzzii. (2021)
Journal Article
(2021). Laboratory and microcosm experiments reveal contrasted adaptive responses to ammonia and water mineralisation in aquatic stages of the sibling species Anopheles gambiae (sensu stricto) and Anopheles coluzzii. Parasites and Vectors, 17 - ?. https://doi.org/10.1186/s13071-020-04483-7

BACKGROUND: The sibling species of the malaria mosquito, Anopheles gambiae (sensu stricto) and Anopheles coluzzii co-exist in many parts of West Africa and are thought to have recently diverged through a process of ecological speciation with gene flo... Read More about Laboratory and microcosm experiments reveal contrasted adaptive responses to ammonia and water mineralisation in aquatic stages of the sibling species Anopheles gambiae (sensu stricto) and Anopheles coluzzii..

Semiochemicals for thrips and their use in pest management (2021)
Journal Article
Kirk. (2021). Semiochemicals for thrips and their use in pest management. Annual Review of Entomology, 101-119. https://doi.org/10.1146/annurev-ento-022020-081531

Thrips (Thysanoptera) are small insects that can cause huge problems in agriculture, horticulture and forestry through feeding and the transmission of plant viruses. They produce a rich chemical diversity of pheromones and allomones and also respond... Read More about Semiochemicals for thrips and their use in pest management.

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae (2020)
Journal Article
Simoni, A., Hammond, A. M., Beaghton, A. K., Galizi, R., Taxiarchi, C., Kyrou, K., …Crisanti, A. (2020). A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. Nature Biotechnology, https://doi.org/10.1038/s41587-020-0508-1

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce uni... Read More about A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae.

Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum) (2020)
Journal Article
(2020). Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum). Conservation Physiology, coaa117 - ?. https://doi.org/10.1093/conphys/coaa117

The white rhinoceros (Ceratotherium simum) is experiencing unsustainable poaching losses fuelled by a demand for horn. Increasingly, private and state reserves are dehorning their rhinoceros populations in an attempt to reduce poaching pressure. Rhin... Read More about Negligible hormonal response following dehorning in free-ranging white rhinoceros (Ceratotherium simum).

Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. (2020)
Journal Article
Buckley, J., Riddell, M., Mellor, D., Bracken, R., Poirier, P., LaGerche, A., & Ross, M. (2020). Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences. British Journal of Sports Medicine, https://doi.org/10.1136/bjsports-2020-102446

Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are significant precursors and comorbidities to cardiovascular disease and prevalence of both types is still rising globally. Currently,~25% of participants (and rising) attending cardiac rehabilitat... Read More about Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences..

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. (2020)
Journal Article
Mycroft-West, C. J., Su, D., Pagani  , I., Rudd  , T. R., Elli  , S., Gandhi  , N. S., …Skidmore   , M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. Thrombosis and Haemostasis, 120(12), 1700 - 1715. https://doi.org/10.1055/s-0040-1721319

The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular glycosaminoglycan heparan sulfate (HS) is exploited by many microbial pathogens as a means o... Read More about Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin..

Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean (Phaseolus vulgaris) Plants Through a Combination of Volatile and Surface Cues (2020)
Journal Article
Mutuku, J., Cunniffe, N., Pickett, J., Carr, J., Woodcock, C., Gilligan, C., …Bruce, T. (2020). Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean (Phaseolus vulgaris) Plants Through a Combination of Volatile and Surface Cues. Frontiers in Plant Science, 11, Article 613772. https://doi.org/10.3389/fpls.2020.613772

Bean common mosaic virus (BCMV), bean common mosaic necrosis virus (BCMNV), and cucumber mosaic virus (CMV) are important pathogens of common bean (Phaseolus vulgaris), a crop vital for food security in sub-Saharan Africa. These viruses are vectored... Read More about Three Aphid-Transmitted Viruses Encourage Vector Migration From Infected Common Bean (Phaseolus vulgaris) Plants Through a Combination of Volatile and Surface Cues.

Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan (2020)
Journal Article
Siam, H., Samy, A., Mohamed, W., Khalid, F., Gumaa, S., Mboera, L., …Ahmed, A. (2020). Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan. PLoS Neglected Tropical Diseases, e0008918 - e0008918. https://doi.org/10.1371/journal.pntd.0008918

Dengue is a rapidly growing public health threat in Kassala state, eastern Sudan. The objective of this study was to determine the seroprevalence, entomological transmission indices, and socioeconomic risk factors associated with dengue in this regio... Read More about Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan.

Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis (2020)
Journal Article
Bhuiyan, M., Stiboy, E., Hassan, M., Chan, M., Islam, M., Haider, N., …Homaira, N. (2021). Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis. Vaccine, 39(4), 667 - 677. https://doi.org/10.1016/j.vaccine.2020.11.078

Introduction Emerging evidence suggests young children are at greater risk of COVID-19 infection than initially predicted. However, a comprehensive understanding of epidemiology of COVID-19 infection in young children under five years, the most at-r... Read More about Epidemiology of COVID-19 infection in young children under five years: A systematic review and meta-analysis.

Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications (2020)
Journal Article
Abedin, N., Alshehri, A. H. A., Almughrbi, A. M., Moore, O., Alyza, S., Rusbridge, E. K., …Fitzpatrick, A. J. (2020). Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications. Polyhedron, 190, 114755. https://doi.org/10.1016/j.poly.2020.114755

A neutral octahedral mononuclear iron(II) tetrabromide complex, [Fe(HAmpy)2Br4], that consists of equatorial bromide and protonated aminopyrazinium axial ligands is successfully synthesised through redox chemistry and analysed using X-ray crystallogr... Read More about Expanding the family of tetrahalide iron complexes: Synthesis, structure and biological applications.