All Outputs (100)

Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans. (2020)
Journal Article
Hyatt, J. G., Prévost, S., Devos, J. M., Mycroft-West, C. J., Skidmore, M. A., & Winter, A. (2020). Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans. Pathogens an international, open access journal of pathogens and pathogen-host interactions, 9(11), Article 935. https://doi.org/10.3390/pathogens9110935

Dengue fever is a rapidly emerging vector-borne viral disease with a growing global burden of approximately 390 million new infections per annum. The Dengue virus (DENV) is a flavivirus spread by female mosquitos of the aedes genus, but the mechanism... Read More about Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans..

Artificial neural networks for monitoring network optimisation—a practical example using a national insect survey (2020)
Journal Article
Bourhis, Y., Bell, J., Bosch, F., V. D., & Milne, A. (2021). Artificial neural networks for monitoring network optimisation—a practical example using a national insect survey. Environmental Modelling and Software, 135, Article 104925. https://doi.org/10.1016/j.envsoft.2020.104925

Monitoring networks are improved by additional sensors. Optimal configurations of sensors give better representations of the process of interest, maximising its exploration while minimising the need for costly infrastructure. By modelling the monitor... Read More about Artificial neural networks for monitoring network optimisation—a practical example using a national insect survey.

Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen (2020)
Journal Article
Gavrin, A., Rey, T., Torode, T. A., Toulotte, J., Chatterjee, A., Louis Kaplan, J., …Schornack, S. (2020). Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen. Current Biology, 4165 - 4176.e5. https://doi.org/10.1016/j.cub.2020.08.011

The cell wall is the primary interface between plant cells and their immediate environment and must balance multiple functionalities, including the regulation of growth, the entry of beneficial microbes, and protection against pathogens. Here, we dem... Read More about Developmental Modulation of Root Cell Wall Architecture Confers Resistance to an Oomycete Pathogen.

How is silicic acid transported in plants? (2020)
Journal Article
(2020). How is silicic acid transported in plants?. Silicon, 2641 - 2645. https://doi.org/10.1007/s12633-019-00360-w

Plants accumulate silicon in their tissues as amorphous silica. The form of silicon taken up by plants is silicic acid, a neutral molecule that passes through membrane channels with water. After seminal work on rice identified an aquaporin that appea... Read More about How is silicic acid transported in plants?.

Larval ecological adaptations, water quality and aquaticbacterial communities in Anopheles gambiae s.l. :prospects for improved rearing techniques towards releaseprogrammes (2020)
Thesis
Akpodiete, N. O. (2020). Larval ecological adaptations, water quality and aquaticbacterial communities in Anopheles gambiae s.l. :prospects for improved rearing techniques towards releaseprogrammes. (Thesis). Keele University

The sibling species Anopheles gambiae s.s. and Anopheles coluzzii are the most important vectors of human malaria in sub-Saharan Africa. They are thought to be undergoing speciation with gene flow with rare viable hybrids but are reproductively isola... Read More about Larval ecological adaptations, water quality and aquaticbacterial communities in Anopheles gambiae s.l. :prospects for improved rearing techniques towards releaseprogrammes.

Assessment of the ecologically dependent post-zygotic isolation between Anopheles coluzzii and Anopheles gambiae. (2020)
Journal Article
(2020). Assessment of the ecologically dependent post-zygotic isolation between Anopheles coluzzii and Anopheles gambiae. PloS one, e0240625 - ?. https://doi.org/10.1371/journal.pone.0240625

Within the Anopheles gambiae complex, the sibling species An. coluzzii and An. gambiae are undergoing sympatric speciation. These species are characterized by rare hybrids in most of their geographical distribution. A strong assortative mating mediat... Read More about Assessment of the ecologically dependent post-zygotic isolation between Anopheles coluzzii and Anopheles gambiae..

Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies (2020)
Journal Article
Matos Rocha, E., de Melo Katak, R., Campos de Oliveira, J., da Silva Araujo, M., Cechetto Carlos, B., Galizi, R., …A. Souza-Neto, J. (2020). Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies. Tropical Medicine and Infectious Disease, 161. https://doi.org/10.3390/tropicalmed5040161

In Brazil, malaria transmission is mostly confined to the Amazon, where substantial progress has been achieved towards disease control in the past decade. Vector control has been historically considered a fundamental part of the main malaria control... Read More about Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies.

Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics (2020)
Journal Article
Galizi, R., Duncan, J. N., Rostain, W., Quinn, C. M., Storch, M., Kushwaha, M., & Jaramillo, A. (2020). Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics. The CRISPR Journal, 398 - 408. https://doi.org/10.1089/crispr.2020.0029

CRISPR guide RNAs (gRNAs) can be programmed with relative ease to allow the genetic editing of nearly any DNA or RNA sequence. Here, we propose novel molecular architectures to achieve RNA-dependent modulation of CRISPR activity in response to specif... Read More about Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics.

The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy. (2020)
Journal Article
Samia, P., Williams, F., Taylor, S., Lindoewood, R., Barton, C., & Buckley, J. (2020). The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy. Disability and Rehabilitation: Assistive Technology, 1 - 11. https://doi.org/10.1080/17483107.2020.1830442

PURPOSE: Appropriate paper-based technology (APT) is used to provide postural support for children with cerebral palsy (CP) in low-resourced settings. This pilot study aimed to evaluate the impact of APT on the children's and families' lives. MATERIA... Read More about The efficacy of appropriate paper-based technology for Kenyan children with cerebral palsy..

Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods. (2020)
Journal Article
(2020). Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods. Parasites and Vectors, 516 - ?. https://doi.org/10.1186/s13071-020-04403-9

BACKGROUND: One of the promising current approaches to curb malaria lies in genetic vector control, the implementation of which will require an improved understanding of the movement of genetic constructs among mosquito populations. To predict potent... Read More about Anopheles gambiae (s.l.) is found where few are looking: assessing mosquito diversity and density outside inhabited areas using diverse sampling methods..

Identification of a Functional Small Noncoding RNA of African Swine Fever Virus (2020)
Journal Article
Dunn, L. E., Ivens, A., Netherton, C. L., Chapman, D. A., & Beard, P. M. (2020). Identification of a Functional Small Noncoding RNA of African Swine Fever Virus. Journal of Virology, 94(21), https://doi.org/10.1128/JVI.01515-20

African swine fever (ASF) poses a major threat to pig populations and food security worldwide. The disease is endemic to Africa and Eastern Europe and is rapidly emerging into Asia, where it has led to the deaths of millions of pigs in the last 12?mo... Read More about Identification of a Functional Small Noncoding RNA of African Swine Fever Virus.

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline (2020)
Journal Article
Elaine Haghighat-Khah, R., Sharma, A., Reis Wunderlich, M., Morselli, G., Anna Marston, L., Bamikole, C., …Galizi, R. (2020). Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline. Pathogens and Global Health, 370 -378. https://doi.org/10.1080/20477724.2020.1803628

Genetic control strategies aimed to bias the sex of progenies towards males present a promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio distortion (SD) system was successfully engineered in Anopheles gambiae b... Read More about Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline.

Money spider dietary choice in pre‐ and post‐harvest cereal crops using metabarcoding (2020)
Journal Article
Cuff, J. P., Drake, L. E., Tercel, M. P., Stockdale, J. E., Orozco-terWengel, P., Bell, J. R., …Symondson, W. O. (2021). Money spider dietary choice in pre‐ and post‐harvest cereal crops using metabarcoding. Ecological Entomology, 46(2), 249-261. https://doi.org/10.1111/een.12957

Money spiders (Linyphiidae) are an important component of conservation biological control in cereal crops, but they rely on alternative prey when pests are not abundant, such as between cropping cycles. To optimally benefit from these generalist pred... Read More about Money spider dietary choice in pre‐ and post‐harvest cereal crops using metabarcoding.

Lockdown measures in response to COVID-19 in nine sub-Saharan African countries (2020)
Journal Article
Haider, N., Osman, A. Y., Gadzekpo, A., Akipede, G. O., Asogun, D., Ansumana, R., …McCoy, D. (2020). Lockdown measures in response to COVID-19 in nine sub-Saharan African countries. BMJ Global Health, 5(10), e003319 - e003319. https://doi.org/10.1136/bmjgh-2020-003319

Lockdown measures have been introduced worldwide to contain the transmission of COVID-19. However, the term ‘lockdown’ is not well-defined. Indeed, WHO’s reference to ‘so-called lockdown measures’ indicates the absence of a clear and universally acce... Read More about Lockdown measures in response to COVID-19 in nine sub-Saharan African countries.

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. (2020)
Journal Article
(2020). Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. Journal of Physiology, 3891 - 3910. https://doi.org/10.1113/JP279795

KEY POINTS: Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurrin... Read More about Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells..

Chikungunya Outbreak in the Republic of the Congo, 2019—Epidemiological, Virological and Entomological Findings of a South-North Multidisciplinary Taskforce Investigation (2020)
Journal Article
Vairo, F., Aimè Coussoud-Mavoungou, M., Ntoumi, F., Castilletti, C., Kitembo, L., Haider, N., …Ippolito, G. (2020). Chikungunya Outbreak in the Republic of the Congo, 2019—Epidemiological, Virological and Entomological Findings of a South-North Multidisciplinary Taskforce Investigation. Viruses, 1020 - 1020. https://doi.org/10.3390/v12091020

The Republic of Congo (RoC) declared a chikungunya (CHIK) outbreak on 9 February 2019. We conducted a ONE-Human-Animal HEALTH epidemiological, virological and entomological investigation. Methods: We collected national surveillance and epidemiologica... Read More about Chikungunya Outbreak in the Republic of the Congo, 2019—Epidemiological, Virological and Entomological Findings of a South-North Multidisciplinary Taskforce Investigation.

The Global Health Security index and Joint External Evaluation score for health preparedness are not correlated with countries' COVID-19 detection response time and mortality outcome (2020)
Journal Article
Haider, N., Yavlinsky, A., Chang, Y., Hasan, M. N., Benfield, C., Osman, A. Y., …Kock, R. (2020). The Global Health Security index and Joint External Evaluation score for health preparedness are not correlated with countries' COVID-19 detection response time and mortality outcome. Epidemiology and Infection, 1-8. https://doi.org/10.1017/s0950268820002046

Abstract Global Health Security Index (GHSI) and Joint External Evaluation (JEE) are two well-known health security and related capability indices. We hypothesised that countries with higher GHSI or JEE scores would have detected their first COVID-19... Read More about The Global Health Security index and Joint External Evaluation score for health preparedness are not correlated with countries' COVID-19 detection response time and mortality outcome.

Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity (2020)
Journal Article
Kozlova, E. V., Hegde, S., Roundy, C. M., Golovko, G., Saldaña, M. A., Hart, C. E., …Hughes, G. L. (2021). Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity. ISME Journal, 15(1), 93-108. https://doi.org/10.1038/s41396-020-00763-3

How microbe–microbe interactions dictate microbial complexity in the mosquito gut is unclear. Previously we found that, Serratia, a gut symbiont that alters vector competence and is being considered for vector control, poorly colonized Aedes aegypti... Read More about Microbial interactions in the mosquito gut determine Serratia colonization and blood-feeding propensity.

Antimicrobial resistance preparedness in sub-Saharan African countries (2020)
Journal Article
Abdel Hamid, M., Haider, N., Kock, R., Ippolito, G., Zumla, A., McHugh, T., …Ntoumi, F. (2020). Antimicrobial resistance preparedness in sub-Saharan African countries. Antimicrobial Resistance and Infection Control, 9, Article 145. https://doi.org/10.1186/s13756-020-00800-y

Background Antimicrobial resistance (AMR) is of growing concern globally and AMR status in sub-Saharan Africa (SSA) is undefined due to a lack of real-time data recording, surveillance and regulation. World Health Organization (WHO) Joint External E... Read More about Antimicrobial resistance preparedness in sub-Saharan African countries.

Over-Winter Survival and Nest Site Selection of the West-European Hedgehog (Erinaceus europaeus) in Arable Dominated Landscapes. (2020)
Journal Article
(2020). Over-Winter Survival and Nest Site Selection of the West-European Hedgehog (Erinaceus europaeus) in Arable Dominated Landscapes. Animals, https://doi.org/10.3390/ani10091449

The West-European hedgehog (Erinaceus europaeus) has declined markedly in the UK. The winter hibernation period may make hedgehogs vulnerable to anthropogenic habitat and climate changes. Therefore, we studied two contrasting populations in England t... Read More about Over-Winter Survival and Nest Site Selection of the West-European Hedgehog (Erinaceus europaeus) in Arable Dominated Landscapes..