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All Outputs (1197)

Characterizing Biomechanics of Limbal Niche Using Vibrational Optical Coherence Elastography (2024)
Journal Article
Dimmock, R., Zhang, Y., Butt, G., Rauz, S., Huang, Z., & Yang, Y. (in press). Characterizing Biomechanics of Limbal Niche Using Vibrational Optical Coherence Elastography. Journal of Biophotonics, Article e202400172. https://doi.org/10.1002/jbio.202400172

The limbal niche is an adult source of epithelial stem cells which regenerate the cornea epithelium. The architecture and biomechanical properties of the limbus have previously been demonstrated to change due to aging and disease. This study aims to... Read More about Characterizing Biomechanics of Limbal Niche Using Vibrational Optical Coherence Elastography.

Global landmark: 2023 marks the worst year for dengue cases with millions infected and thousands of deaths reported (2024)
Journal Article
Haider, N., Nayeem Hasan, M., Onyango, J., & Asaduzzaman, M. (2024). Global landmark: 2023 marks the worst year for dengue cases with millions infected and thousands of deaths reported. IJID Regions, 13, Article 100459. https://doi.org/10.1016/j.ijregi.2024.100459

Objectives
In 2023, the world experienced the worst dengue virus (DENV) outbreak on record. This study aims to identify global regions and continents with a high burden of Dengue in 2023.... Read More about Global landmark: 2023 marks the worst year for dengue cases with millions infected and thousands of deaths reported.

The Wildlife Malaria Research network (WIMANET): Meeting report on the 1st WIMANET workshop (2024)
Journal Article
Gutiérrez-López, R., Ferraguti, M., Bodawatta, K. H., Chagas, C. R., Chakarov, N., Duc, M., …Dunn, J. C. (2024). The Wildlife Malaria Research network (WIMANET): Meeting report on the 1st WIMANET workshop. International Journal for Parasitology: Parasites and Wildlife, 25, Article 100989. https://doi.org/10.1016/j.ijppaw.2024.100989

The Wildlife Malaria Network (WIMANET) is a groundbreaking multinational collaboration focused on studying vector-borne haemosporidian parasites in wildlife. Unlike human malaria, wildlife malaria is found on all continents except Antarctica, with pa... Read More about The Wildlife Malaria Research network (WIMANET): Meeting report on the 1st WIMANET workshop.

Circadian clock period length is not consistently linked to chronotype in a wild songbird (2024)
Journal Article
Tomotani, B., Strauß, A., Kishkinev, D., van de Haar, H., & Helm, B. (2024). Circadian clock period length is not consistently linked to chronotype in a wild songbird. European Journal of Neuroscience, https://doi.org/10.1111/ejn.16535

Circadian clock properties vary between individuals and relate to variation in entrained timing in captivity. How this variation translates into behavioural differences in natural settings, however, is poorly understood. Here we tested in great tits... Read More about Circadian clock period length is not consistently linked to chronotype in a wild songbird.

Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis (2024)
Working Paper
Stevens, E., Li, J., Hector, T., Drew, G., Hoang, K., Greenrod, S., …King, K. Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis

Pathogens newly invading a host must compete with resident microbiota. This within-host microbial warfare could lead to more severe disease outcomes or constrain the evolution of virulence. Using experimental evolution of a widespread pathogen (Staph... Read More about Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis.

Molecular regulation of axon termination in mechanosensory neurons (2024)
Journal Article
Desbois, M., & Grill, B. (2024). Molecular regulation of axon termination in mechanosensory neurons. Development, 151(17), https://doi.org/10.1242/dev.202945

Spatially and temporally accurate termination of axon outgrowth, a process called axon termination, is required for efficient, precise nervous system construction and wiring. The mechanosensory neurons that sense low-threshold mechanical stimulation... Read More about Molecular regulation of axon termination in mechanosensory neurons.

Applying electron microscopy analysis to assess neural tissue engineering outcomes (2024)
Thesis
Lindop, G. E. (2024). Applying electron microscopy analysis to assess neural tissue engineering outcomes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/884963

Spinal cord injury (SCI) has a major socio-economic impact with treatments providing little to no functional recovery due to the SCI environment hindering regeneration through chemical and physical barriers. Novel approaches to alter the injury envir... Read More about Applying electron microscopy analysis to assess neural tissue engineering outcomes.

Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival (2024)
Thesis
Maroszek, M. R. Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/884975

Current research indicates that long noncoding RNAs orchestrate various regulatory processes in a physiological context and thereby, their dysregulation may contribute to major human diseases, including cancer (Grammatikakis et al.,2014).

Long no... Read More about Investigation into the mechanistic effects of the lncRNA Growth Arrest Specific 5 in the regulation of cell survival.

Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial (2024)
Journal Article
Ramos da Silva Grillo, V. T., Bertanha, M., da Silva Rodrigues, L., de Lima, M. A., Mellucci Filho, P. L., Rahal Guaragna Machado, R., …Fortaleza, C. M. C. B. (in press). Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial. Scientific Reports, 14(1), Article 19902. https://doi.org/10.1038/s41598-024-70064-8

To evaluate the safety and the potential antiviral treatment of inhaled enriched heparin in patients with COVID-19. The specific objectives were to investigate the anticoagulation profile, antiviral and anti-inflammatory effects, and respiratory evol... Read More about Nebulized enriched heparin improves respiratory parameters in patients with COVID-19: a phase I/II randomized and triple-blind clinical trial.

The role of new dengue vaccines in curtailing the emerging global threat of dengue outbreaks arising from mass gathering sporting and religious events. (2024)
Journal Article
Petersen, E., Elton, L., Haider, N., McHugh, T. D., Dar, O., Sharma, A., …Zumla, A. (2024). The role of new dengue vaccines in curtailing the emerging global threat of dengue outbreaks arising from mass gathering sporting and religious events. International Journal of Infectious Diseases, Article 107216. https://doi.org/10.1016/j.ijid.2024.107216

Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa (2024)
Journal Article
Li, X., Cheng, J., Han, H., Kirk, W. D., O’Brien, M., Wang, L., …Lu, Y. (in press). Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa. Journal of Chemical Ecology, https://doi.org/10.1007/s10886-024-01532-8

Odontothrips loti (Haliday) (Thysanoptera: Thripidae) is one of the most serious pests on alfalfa, causing direct damage by feeding and indirect damage by transmitting plant viruses. This damage causes significant loss in alfalfa production. Semioche... Read More about Identification of Aggregation Pheromone as an Attractant for Odontothrips loti, A Serious Thrips Pest on Alfalfa.

'The Garlic Gambit': an alternative strategy for controlling vine weevil (Otiorhynchus sulcatus F.; Coleoptera: Curculionidae). (2024)
Journal Article
Fezza, E., Roberts, J. M., Bruce, T. J. A., Walsh, L. E., Gaffney, M. T., & Pope, T. W. (in press). 'The Garlic Gambit': an alternative strategy for controlling vine weevil (Otiorhynchus sulcatus F.; Coleoptera: Curculionidae). Journal of Economic Entomology, 117(5), 1968-1976. https://doi.org/10.1093/jee/toae175

Plant protection products derived from plant material are proposed to be a sustainable alternative to conventional synthetic chemical pesticides. This study determines the efficacy of a commercially available bioinsecticide based on garlic (Allium sa... Read More about 'The Garlic Gambit': an alternative strategy for controlling vine weevil (Otiorhynchus sulcatus F.; Coleoptera: Curculionidae)..

High prevalence of multi-drug resistant bacteria in faecal samples from UK passerine birds (2024)
Journal Article
Dunn, J. C., & Clegg, S. R. (2024). High prevalence of multi-drug resistant bacteria in faecal samples from UK passerine birds. bioRxiv, https://doi.org/10.1101/2024.07.24.604896

Wild birds are a near ubiquitous sight in gardens, offering pleasure to many people through supplementary feeding, song, or other interactions. However, they are also potential carriers of many pathogens, including Campylobacter, Salmonella, Enteroco... Read More about High prevalence of multi-drug resistant bacteria in faecal samples from UK passerine birds.

Rabies control in Bangladesh and prediction of human rabies cases by 2030: a One Health approach (2024)
Journal Article
Ghosh, S., Nayeem Hasan, M., Deb Nath, N., Haider, N., Higgins Jones, D., Kamrul Islam, M., …Nazmul Islam, M. (2024). Rabies control in Bangladesh and prediction of human rabies cases by 2030: a One Health approach. The Lancet Regional Health - Southeast Asia, 27, Article 100452. https://doi.org/10.1016/j.lansea.2024.100452

Background
Bangladesh is making progress toward achieving zero dog-mediated rabies deaths by 2030, a global goal set in 2015.

Methods
Drawing from multiple da... Read More about Rabies control in Bangladesh and prediction of human rabies cases by 2030: a One Health approach.

Scanning the skies for migrants: Conservation-focused opportunities for a pan-European automated telemetry network (2024)
Working Paper
Mitchell, L., Brust, V., Karwinkel, T., Åkesson, S., Kishkinev, D., Norevik, G., …Schmaljohann, H. Scanning the skies for migrants: Conservation-focused opportunities for a pan-European automated telemetry network

Accelerated biodiversity loss during the Anthropocene has destabilised functional links within and between ecosystems. Migratory species that cross different ecosystems on their repeated journeys between breeding and non-breeding sites are particular... Read More about Scanning the skies for migrants: Conservation-focused opportunities for a pan-European automated telemetry network.

Investigating multiple factors affecting the successful infection and transmission of arboviruses (2024)
Thesis
Widlake, E. (2024). Investigating multiple factors affecting the successful infection and transmission of arboviruses. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/850302

Arboviruses are arthropod-borne viruses that cycle between a vertebrate host and an arthropod vector. This disparate life cycle involves adapting to two alternate animals and the differing tissues and systems within them. A range of factors influence... Read More about Investigating multiple factors affecting the successful infection and transmission of arboviruses.

Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems (2024)
Thesis
Nascimento, C. L. D. (2024). Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853170

Vector-borne diseases are responsible for 17% of all infectious diseases worldwide and contribute to more than 700 000 deaths annually, mainly in sub-Saharan countries. Vector surveillance is a crucial element of vector control programmes to assure t... Read More about Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems.

Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum (2024)
Thesis
Mobley, R. M. (2024). Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853179

Malaria continues to cause great global health concerns despite efforts for control and elimination. The emergence of resistance to components of the frontline artemisinin combination therapy highlights the urgent need for novel malaria therapeutics... Read More about Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum.