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Epidemiology of paediatric presentations with musculoskeletal problems in primary care (2018)
Journal Article
Protheroe. (2018). Epidemiology of paediatric presentations with musculoskeletal problems in primary care. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-018-1952-7

Background Musculoskeletal disease is a common cause of morbidity, but there is a paucity of musculoskeletal research focusing on paediatric populations, particularly in primary care settings. In particular, there is limited information on populatio... Read More about Epidemiology of paediatric presentations with musculoskeletal problems in primary care.

Twelve tips for expanding undergraduate clinical teaching capacity (2018)
Journal Article
(2018). Twelve tips for expanding undergraduate clinical teaching capacity. Medical Teacher, 1 -4. https://doi.org/10.1080/0142159X.2018.1429587

Undergraduate medical education has expanded substantially in recent years, through both establishing new programs and increasing student numbers in existing programs. This expansion has placed pressure on the capacity for training students in clinic... Read More about Twelve tips for expanding undergraduate clinical teaching capacity.

Twelve tips for expanding undergraduate clinical teaching capacity (2018)
Journal Article
(2018). Twelve tips for expanding undergraduate clinical teaching capacity. Medical Teacher, https://doi.org/10.1080/0142159X.2018.1429587

Undergraduate medical education has expanded substantially in recent years, through both establishing new programs and increasing student numbers in existing programs. This expansion has placed pressure on the capacity for training students in clinic... Read More about Twelve tips for expanding undergraduate clinical teaching capacity.

Early and late pregnancy outcomes in women treated with cold-coagulation versus LLETZ cervical treatment for cervical intraepithelial neoplasia; a retrospective cohort study (2018)
Journal Article
Papoutsis, D., Underwood, M., Parry-Smith, W., & Panikkar, J. (2018). Early and late pregnancy outcomes in women treated with cold-coagulation versus LLETZ cervical treatment for cervical intraepithelial neoplasia; a retrospective cohort study. Archives of Gynecology and Obstetrics, 297(4), 1015-1025. https://doi.org/10.1007/s00404-018-4704-x

Purpose To compare the pregnancy outcomes between women who were treated with cold-coagulation versus large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia. Methods This was a retrospective cohort study of... Read More about Early and late pregnancy outcomes in women treated with cold-coagulation versus LLETZ cervical treatment for cervical intraepithelial neoplasia; a retrospective cohort study.

Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action (2018)
Journal Article
Posadzki, P. P., Bajpai, R., Kyaw, B. M., Roberts, N. J., Brzezinski, A., Christopoulos, G. I., …Car, J. (2018). Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC Medicine, 16, Article 18. https://doi.org/10.1186/s12916-017-1000-8

Background Our aims were to evaluate critically the evidence from systematic reviews as well as narrative reviews of the effects of melatonin (MLT) on health and to identify the potential mechanisms of action involved. Methods An umbrella review... Read More about Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action.

Challenges of diagnosis and management of giant cell arteritis in general practice: a multimethods study (2018)
Journal Article
Helliwell, T., Muller, S., Hider, S. L., Prior, J. A., Richardson, J. C., & Mallen, C. D. (2018). Challenges of diagnosis and management of giant cell arteritis in general practice: a multimethods study. BMJ Open, 8(2), Article e019320. https://doi.org/10.1136/bmjopen-2017-019320

BACKGROUND: In the UK, general practitioners (GPs) are usually the first medical contact for patients with suspected giant cell arteritis (GCA). While rare, it is critical not to miss, as delayed treatment can lead to significant complications includ... Read More about Challenges of diagnosis and management of giant cell arteritis in general practice: a multimethods study.

PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer. (2018)
Journal Article
(2018). PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer. Health Technology Assessment, 1 - 114. https://doi.org/10.3310/hta22070

BACKGROUND: Pancreatic cancer diagnosis and staging can be difficult in 10-20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of PET/CT may add further value t... Read More about PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer..

Trajectories and predictors of the long-term course of low back pain: cohort study with 5-year follow-up (2018)
Journal Article
Jordan, K., Dunn, K., Strauss, V., Foster, N., Chen, Y., & Campbell, P. (2018). Trajectories and predictors of the long-term course of low back pain: cohort study with 5-year follow-up. PAIN, 252-260. https://doi.org/10.1097/j.pain.0000000000001097

Low back pain (LBP) is a major health challenge globally. Research has identified common trajectories of pain over time. We aimed to investigate whether trajectories described in one primary care cohort can be confirmed in another, and to determine t... Read More about Trajectories and predictors of the long-term course of low back pain: cohort study with 5-year follow-up.

Subacromial impingement syndrome - What does this mean to and for the patient? A qualitative study (2018)
Journal Article
(2018). Subacromial impingement syndrome - What does this mean to and for the patient? A qualitative study. Musculoskeletal Science and Practice, 24-28. https://doi.org/10.1016/j.msksp.2017.10.008

Background Structured exercise has been reported as the current treatment of choice for patients diagnosed with subacromial impingement syndrome (SIS). However, it has been suggested that this diagnostic term and the language used to explain this co... Read More about Subacromial impingement syndrome - What does this mean to and for the patient? A qualitative study.

Development and validation of risk prediction models for cardiovascular mortality in Chinese people initialising peritoneal dialysis: a cohort study (2018)
Journal Article
Yu. (2018). Development and validation of risk prediction models for cardiovascular mortality in Chinese people initialising peritoneal dialysis: a cohort study. Scientific reports, https://doi.org/10.1038/s41598-018-20160-3

Cardiovascular disease is the leading cause of death among patients receiving peritoneal dialysis. We aimed to develop and validate a risk prediction model for cardiovascular death within 2 years after the initiation of peritoneal dialysis (PD). A co... Read More about Development and validation of risk prediction models for cardiovascular mortality in Chinese people initialising peritoneal dialysis: a cohort study.

Effects of fatigue on center-of-mass acceleration during a prolonged overground run (2018)
Journal Article
Winter. (2018). Effects of fatigue on center-of-mass acceleration during a prolonged overground run. https://doi.org/10.35841/physical-therapy.2.1.10-14

Objective: The aim of this study was to assess for fatigue related changes in center-of-mass (COM) acceleration during a prolonged overground run in a group of healthy male runners using a tri-axial accelerometer attached to a runner’s low back. Meth... Read More about Effects of fatigue on center-of-mass acceleration during a prolonged overground run.

Pain and Mortality in Older Adults: The Influence of Pain Phenotype. (2018)
Journal Article
Smith, D., Wilkie, R., Croft, P., & McBeth, J. (2018). Pain and Mortality in Older Adults: The Influence of Pain Phenotype. Arthritis Care and Research, 70(2), 236 - 243. https://doi.org/10.1002/acr.23268

OBJECTIVE: Moderate to severe chronic pain affects 1 in 5 adults. Pain may increase the risk of mortality, but the relationship is unclear. This study investigated whether mortality risk was influenced by pain phenotype, characterized by pain extent... Read More about Pain and Mortality in Older Adults: The Influence of Pain Phenotype..

Can we use creative free rein to enhance student skill learning? (2018)
Journal Article
Aynsley. (2018). Can we use creative free rein to enhance student skill learning?. The Journal of Academic Development and Education, https://doi.org/10.21252/KEELE-0000024

Tasks which are solely formative sometimes suffer from a lack of student engagement, however these tasks are often included to teach students essential skills and the intended benefit is in engaging with the process not necessarily the finished outco... Read More about Can we use creative free rein to enhance student skill learning?.

Quality of life, sleep and rheumatoid arthritis (QUASAR): a protocol for a prospective UK mHealth study to investigate the relationship between sleep and quality of life in adults with rheumatoid arthritis. (2018)
Journal Article
(2018). Quality of life, sleep and rheumatoid arthritis (QUASAR): a protocol for a prospective UK mHealth study to investigate the relationship between sleep and quality of life in adults with rheumatoid arthritis. BMJ Open, e018752 - ?. https://doi.org/10.1136/bmjopen-2017-018752

INTRODUCTION: People with rheumatoid arthritis (RA) frequently report reduced health-related quality of life (HRQoL), the impact one's health has on physical, emotional and social well-being. There are likely numerous causes for poor HRQoL, but peopl... Read More about Quality of life, sleep and rheumatoid arthritis (QUASAR): a protocol for a prospective UK mHealth study to investigate the relationship between sleep and quality of life in adults with rheumatoid arthritis..

Psychosocial factors partially mediate the relationship between mechanical hyperalgesia and self-reported pain (2018)
Journal Article
Mason, K. J., O'Neill, T. W., Lunt, M., Jones, A. K. P., & McBeth, J. (2018). Psychosocial factors partially mediate the relationship between mechanical hyperalgesia and self-reported pain. Scandinavian Journal of Pain, 18(1), 59-69. https://doi.org/10.1515/sjpain-2017-0109

Background and aims: Amplification of sensory signalling within the nervous system along with psychosocial factors contributes to the variation and severity of knee pain. Quantitative sensory testing (QST) is a non-invasive test battery that assesse... Read More about Psychosocial factors partially mediate the relationship between mechanical hyperalgesia and self-reported pain.

Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies (2018)
Journal Article
Wu, P., Farrell, W., Haworth, K., Emes, R., Kitchen, M., Glossop, J., …Fryer, A. (2018). Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 122-128. https://doi.org/10.1080/15592294.2016.1166321

Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to det... Read More about Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Does vitamin D supplementation improve bone density in vitamin D-deficient children? Protocol for an individual patient data meta-analysis. (2018)
Journal Article
(2018). Does vitamin D supplementation improve bone density in vitamin D-deficient children? Protocol for an individual patient data meta-analysis. BMJ Open, e019584 - ?. https://doi.org/10.1136/bmjopen-2017-019584

INTRODUCTION: Our previous study-level (aggregate data) meta-analysis suggested that vitamin D supplements may be beneficial for bone density specifically in children with vitamin D deficiency. However, the misclassification of vitamin D status inher... Read More about Does vitamin D supplementation improve bone density in vitamin D-deficient children? Protocol for an individual patient data meta-analysis..

Foot osteoarthritis: latest evidence and developments (2018)
Journal Article
Roddy, E., & Menz, H. B. (2018). Foot osteoarthritis: latest evidence and developments. Therapeutic Advances in Musculoskeletal Disease, 10(4), 91-103. https://doi.org/10.1177/1759720x17753337

Foot osteoarthritis (OA) is a common problem in older adults yet is under-researched compared to knee or hand OA. Most existing studies focus on the first metatarsophalangeal joint, with evidence relating to midfoot OA being particularly sparse. Symp... Read More about Foot osteoarthritis: latest evidence and developments.