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Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis (2021)
Journal Article
Hay, C. A., Prior, J. A., Belcher, J., Mallen, C. D., & Roddy, E. (2021). Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis. Arthritis Care & Research, 73(7), 1049-1054. https://doi.org/10.1002/acr.24205

ObjectiveUrate‐lowering therapy (predominantly allopurinol) is highly effective as a treatment for gout, but its wider long‐term effects remain unclear. This systematic review and meta‐analysis aimed to ascertain the association between mortality and... Read More about Mortality in Patients With Gout Treated With Allopurinol: A Systematic Review and Meta‐Analysis.

The haematological side effects of clozapine: literature review and meta-analysis (2021)
Journal Article
Munshi, T., Naeem, F., Ayub, M., Farooq, S., Khachatryan, D., Asmer, S., …Fairbairn, J. (2021). The haematological side effects of clozapine: literature review and meta-analysis. BJPsych Open, 7(S1), https://doi.org/10.1192/bjo.2021.729

Aims This review and meta-analysis aim to estimate the cumulative incidence of clozapine induced agranulocytosis and leukopenia the impact of the associated factors such as dose of clozapine, duration of follow-up, gender and race on the cumulative... Read More about The haematological side effects of clozapine: literature review and meta-analysis.

Describing the burden of the COVID-19 pandemic in people with psoriasis: findings from a global cross-sectional study. (2021)
Journal Article
Mahil, S., Yates, M., Yiu, Z., Langan, S., Tsakok, T., Dand, N., …Smith, C. (2021). Describing the burden of the COVID-19 pandemic in people with psoriasis: findings from a global cross-sectional study. Journal of the European Academy of Dermatology and Venereology, 35(10), e636-e640. https://doi.org/10.1111/jdv.17450

Indirect excess morbidity in the COVID-19 pandemic may arise from public health risk-mitigation efforts such as stay-at-home orders and re-purposing of healthcare services1 . Increased mental health disorders and shortfalls in the care of long-term c... Read More about Describing the burden of the COVID-19 pandemic in people with psoriasis: findings from a global cross-sectional study..

Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis (2021)
Journal Article
McLarnon, M., & Heron, N. (2021). Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis. BMC Musculoskeletal Disorders, 22(1), Article ARTN 550. https://doi.org/10.1186/s12891-021-04308-3

Intra-articular (IA) corticosteroid (CS) injections are the mainstay of treatment for symptomatic management in knee osteoarthritis (OA), particularly in the UK. IA platelet-rich plasma (PRP) injections are a promising alternative, but no systematic... Read More about Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: systematic review and meta-analysis.

Combining expert judgment and psychometric information to create the Global Scale for Early Development (GSED) (2021)
Presentation / Conference
McCray, G., Gladstone, M., Cavallera, V., McCoy, D., Waldman, M., Eekhout, I., …Weber, A. (2021, June). Combining expert judgment and psychometric information to create the Global Scale for Early Development (GSED). Paper presented at Proceedings of the Patient Reported Outcome Measures (PROMs) Research Conference, Sheffield, UK

Background: The Global Scale for Early Development (GSED) a global and culturally neutral measure of child development under 3 years of age is designed to allow comparisons within and across countries. The project has been undertaken by an experience... Read More about Combining expert judgment and psychometric information to create the Global Scale for Early Development (GSED).

Coronary revascularisation outcomes in patients with cancer. (2021)
Journal Article
Mamas. (2021). Coronary revascularisation outcomes in patients with cancer. Heart, 507 - 516. https://doi.org/10.1136/heartjnl-2020-318531

Cancer and coronary artery disease (CAD) overlap in traditional risk factors as well as molecular mechanisms underpinning the development of these two disease states. Patients with cancer are at increased risk of developing CAD, representing a high-r... Read More about Coronary revascularisation outcomes in patients with cancer..

Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements. (2021)
Journal Article
Dhawan, R., Spencer Jones, R., & Cool, P. (2021). Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements. Knee, 31, 97 - 109. https://doi.org/10.1016/j.knee.2021.05.008

BACKGROUND: Review of mid-term results (five years) for tumour and revision arthroplasty surgery using the Stanmore METS® distal femoral replacement. METHODS: Data were collected retrospectively for 90 patients for procedures performed between 20... Read More about Distal femoral replacement - Does length matter? Mid-term results for distal femoral replacements..

Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. (2021)
Journal Article
Dafaalla, M., Rashid, M., Weston, C., Kinnaird, T., Gurm, H., Appleby, C., …Mamas, M. (2021). Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales. American Journal of Cardiology, 152, 1 - 10. https://doi.org/10.1016/j.amjcard.2021.04.032

We investigated the incidence, management, and outcomes of acute myocardial infarction (AMI) patients according to cardiac arrest location. Patients admitted with a diagnosis of AMI between January 1, 2010 to March 31, 2017 from the Myocardial Ischae... Read More about Effect of Location on Treatment and Outcomes of Cardiac Arrest Complicating Acute Myocardial Infarction in England & Wales..

Diet and physical activity in pregnancy to prevent gestational diabetes: a protocol for an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. (2021)
Journal Article
(2021). Diet and physical activity in pregnancy to prevent gestational diabetes: a protocol for an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation. BMJ Open, e048119 - ?. https://doi.org/10.1136/bmjopen-2020-048119

INTRODUCTION: Mothers with gestational diabetes mellitus (GDM) are at increased risk of pregnancy-related complications and developing type 2 diabetes after delivery. Diet and physical activity-based interventions may prevent GDM, but variations in p... Read More about Diet and physical activity in pregnancy to prevent gestational diabetes: a protocol for an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation..

Shared Decision-Making With a Virtual Patient in Medical Education: Mixed Methods Evaluation Study. (2021)
Journal Article
Jacklin, S. (2021). Shared Decision-Making With a Virtual Patient in Medical Education: Mixed Methods Evaluation Study. JMIR Medical Education, e22745 - ?. https://doi.org/10.2196/22745

BACKGROUND: Shared decision-making (SDM) is a process in which clinicians and patients work together to select tests, treatments, management, or support packages based on clinical evidence and the patient's informed preferences. Similar to any skill,... Read More about Shared Decision-Making With a Virtual Patient in Medical Education: Mixed Methods Evaluation Study..

Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. (2021)
Journal Article
Ward, R. J., Fryer, A. A., Hanna, F. W., Spencer, N., Mahmood, M., Wu, P., …Duff, C. J. (2021). Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years. International Journal of Clinical Practice, e14447 - ?. https://doi.org/10.1111/ijcp.14447

INTRODUCTION: Women with gestational diabetes (GDM) are at greatly increased risk of type 2 diabetes (T2DM). The UK guidance recommends screening for T2DM at around 6 weeks post-partum and annually thereafter. We evaluated conformity to this guidance... Read More about Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years..

Syndecan-3: A Signaling Conductor in the Musculoskeletal System (2021)
Book Chapter
Jones, F. K., Kehoe, O., Daroszewska, A., van’t Hof, R. J., & Pisconti, A. (2021). Syndecan-3: A Signaling Conductor in the Musculoskeletal System. In Proteoglycans in Stem Cells (153-177). Springer. https://doi.org/10.1007/978-3-030-73453-4_7

Syndecan-3 is a transmembrane proteoglycan, the largest of the four syndecan family members and the most mysterious. To date, the number of published studies involving syndecan-3 is only a small fraction of the number of studies involving the other s... Read More about Syndecan-3: A Signaling Conductor in the Musculoskeletal System.

Refinement and validation of a tool for stratifying patients with musculoskeletal pain (2021)
Journal Article
Dunn, K. M., Campbell, P., Lewis, M., Hill, J. C., van der Windt, D. A., Afolabi, E., …Foster, N. E. (2021). Refinement and validation of a tool for stratifying patients with musculoskeletal pain. European Journal of Pain, 25(10), 2081-2093. https://doi.org/10.1002/ejp.1821

AbstractBackgroundPatients with musculoskeletal pain in different body sites share common prognostic factors. Using prognosis to stratify and treatment match can be clinically and cost‐effective. We aimed to refine and validate the Keele STarT MSK To... Read More about Refinement and validation of a tool for stratifying patients with musculoskeletal pain.

Urate Lowering for Blood Pressure Control in Adults: Another Nail in the Coffin? (2021)
Journal Article
Roddy, E., & Dalbeth, N. (2021). Urate Lowering for Blood Pressure Control in Adults: Another Nail in the Coffin?. Arthritis and Rheumatology, 73(8), 1408-1411. https://doi.org/10.1002/art.41751

Numerous observational studies have reported an association between serum urate and elevated blood pressure in adult populations (1). These observations, together with experimental in vivo studies, have generated substantial interest in the role of h... Read More about Urate Lowering for Blood Pressure Control in Adults: Another Nail in the Coffin?.

Synthetic biology open language visual (SBOL Visual) version 2.3. (2021)
Journal Article
Madsen, C., Misirli, G., Palchick, Z., Pocock, M., Roehner, N., Sauro, H., …Bartley Bartley, B. (2021). Synthetic biology open language visual (SBOL Visual) version 2.3

People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and oth... Read More about Synthetic biology open language visual (SBOL Visual) version 2.3..