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Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis (2022)
Journal Article
Kathpalia, M., Mishra, P., Bajpai, R., Bhurani, D., & Agarwal, N. (2022). Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis. Annals of Hematology, 101(8), 1655-1666. https://doi.org/10.1007/s00277-022-04880-1

Nelarabine is approved for the treatment of relapsed/refractory (R/R) T-cell acute lymphoblastic leukemia (T-ALL) patients who relapse following at least two different chemotherapy regimens. Previous studies have evaluated the efficacy and safety of... Read More about Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis.

Can we mitigate the psychological impacts of social isolation using behavioural activation? Long-term results of the UK BASIL Urgent Public Health COVID-19 pilot randomised controlled trial and living systematic review (2022)
Journal Article
Chew-Graham. (2022). Can we mitigate the psychological impacts of social isolation using behavioural activation? Long-term results of the UK BASIL Urgent Public Health COVID-19 pilot randomised controlled trial and living systematic review. MedRxiv, https://doi.org/10.1101/2022.06.20.22276641

Background Behavioural and cognitive interventions remain a credible approach in preventing loneliness and depression. There was a need to rapidly generate and assimilate trial-based data during COVID-19. Objectives We undertook a COVID-19 parallel p... Read More about Can we mitigate the psychological impacts of social isolation using behavioural activation? Long-term results of the UK BASIL Urgent Public Health COVID-19 pilot randomised controlled trial and living systematic review.

COVID-19 health information needs of older adults from ethnic minority groups in the UK: a qualitative study (2022)
Journal Article
Paudyal, P., Skinner, E., Majeed-Hajaj, S., Hughes, L. J., Khapangi Magar, N., Isobel Keeling, D., …Cassell, J. A. (2022). COVID-19 health information needs of older adults from ethnic minority groups in the UK: a qualitative study. BMJ Open, e059844 - e059844. https://doi.org/10.1136/bmjopen-2021-059844

ObjectiveThis study aimed to identify the COVID-19 health information needs of older adults from ethnic minority groups in the UK.Study designA qualitative study using semistructured interviews.Setting and participantsIndian and Nepalese older adults... Read More about COVID-19 health information needs of older adults from ethnic minority groups in the UK: a qualitative study.

COVID-19 exit strategy during vaccine implementation: a balance between social distancing and herd immunity (2022)
Journal Article
Daher-Nashif, S., Al-Anany, R., Ali, M., Erradi, K., Farag, E., Abdallah, A. M., & Emara, M. M. (2022). COVID-19 exit strategy during vaccine implementation: a balance between social distancing and herd immunity. Archives of Virology, 167(9), 1773-1783. https://doi.org/10.1007/s00705-022-05495-7

There is a sound empirical basis for hypofractionation in radiotherapy for breast cancer. This article reviews the radiobiological implications of hypofractionation in breast cancer derived from a series of clinical trials that began when 50 Gy in 25... Read More about COVID-19 exit strategy during vaccine implementation: a balance between social distancing and herd immunity.

Healthcare utilization and related costs among older people seeking primary care due to back pain: findings from the BACE-N cohort study (2022)
Journal Article
Munk Killingmo, R., Storheim, K., Van Der Windt, D., Zolic-Karlsson, Z., Nesse Vigdal, Ø., Kretz, L., …Grotle, M. (2022). Healthcare utilization and related costs among older people seeking primary care due to back pain: findings from the BACE-N cohort study. BMJ Open, 12(6), Article ARTN e057778. https://doi.org/10.1136/bmjopen-2021-057778

OBJECTIVES: To describe healthcare utilization and estimate associated costs during 1?year of follow-up among older people seeking primary care due to a new episode back pain and to describe healthcare utilization across patients with different risk... Read More about Healthcare utilization and related costs among older people seeking primary care due to back pain: findings from the BACE-N cohort study.

Exploring the Changes and Challenges of COVID-19 in Adult Safeguarding Practice: Qualitative Findings from a Mixed-Methods Project (2022)
Journal Article
Pritchard-Jones, L., Mehmi, M., Eccleston-Turner, M., & Brammer, A. (2022). Exploring the Changes and Challenges of COVID-19 in Adult Safeguarding Practice: Qualitative Findings from a Mixed-Methods Project. Journal of Adult Protection, 24(3/4), 132-148. https://doi.org/10.1108/JAP-01-2022-0002

Purpose: The purpose of this paper is to present findings from a mixed methods study on the impact COVID-19 has had on adult safeguarding. The research sought to explore the challenges and opportunities presented by COVID-19 to both frontline and no... Read More about Exploring the Changes and Challenges of COVID-19 in Adult Safeguarding Practice: Qualitative Findings from a Mixed-Methods Project.

Timing of induction of labour in the prevention of prolonged pregnancy: Systematic review with meta‐analysis (2022)
Journal Article
J. Geneen, L., Gilbert, J., Reeves, T., Mainie, P., Maresh, M., Smith, L., …Parisaei, M. (2022). Timing of induction of labour in the prevention of prolonged pregnancy: Systematic review with meta‐analysis. Reproductive, Female and Child Health, 1(1), 69-79. https://doi.org/10.1002/rfc2.6

Objective To update the systematic review which informed the National Institute for Health and Care Excellence guideline “Inducing Labour” (NG207), including additional data and analyses, and comparison with a recent individual patient data analysis... Read More about Timing of induction of labour in the prevention of prolonged pregnancy: Systematic review with meta‐analysis.

Perceptions of risk in people with inflammatory arthritis during the COVID-19 pandemic (2022)
Journal Article
Ryan, S., Campbell, P., Paskins, Z., Manning, F., Rule, K., Hassell, A., …Hider, S. (2022). Perceptions of risk in people with inflammatory arthritis during the COVID-19 pandemic. Rheumatology Advances in Practice, 6(2), Article rkac050. https://doi.org/10.1093/rap/rkac050

Objective People with inflammatory arthritis have an increased incidence of serious illness and mortality, placing them at risk of poor outcomes from coronavirus disease 2019 (COVID-19). This study explored patients’ perceptions of risk from COVID-1... Read More about Perceptions of risk in people with inflammatory arthritis during the COVID-19 pandemic.

Worth the paper it's written on- A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK (2022)
Journal Article
Rimmer, M. P., Henderson, I., Parry-Smith, W., Raglan, O., Tamblyn, J., Heazell, A. E. P., …working group, T. U. N. (2023). Worth the paper it's written on- A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK. International Journal of Epidemiology, 52(1), 295–308. https://doi.org/10.1093/ije/dyac100

Background The Medical Certificate of Stillbirth (MCS) records data about a baby’s death after 24 weeks of gestation but before birth. Major errors that could alter interpretation of the MCS were widespread in two UK-based regional studies. Metho... Read More about Worth the paper it's written on- A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK.

Modifiable prognostic factors of high costs related to healthcare utilization among older people seeking primary care due to back pain: an identification and replication study (2022)
Journal Article
Killingmo, R. M., Chiarotto, A., van der Windt, D. A., Storheim, K., Bierma-Zeinstra, S. M. A., Småstuen, M. C., …Grotle, M. (2022). Modifiable prognostic factors of high costs related to healthcare utilization among older people seeking primary care due to back pain: an identification and replication study. BMC Health Services Research, 22(1), Article ARTN 793. https://doi.org/10.1186/s12913-022-08180-2

Abstract Background Back pain is an extensive burden to our healthcare system, yet few studies have explored modifiable prognostic factors associated with high costs related to healthcare utilization, especially among older back pain patients. The ai... Read More about Modifiable prognostic factors of high costs related to healthcare utilization among older people seeking primary care due to back pain: an identification and replication study.

A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease (2022)
Journal Article
Dashtban, A., Mizani, M. A., Denaxas, S., Nitsch, D., Quint, J., Corbett, R., …Banerjee, A. (2022). A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease. Kidney International, 102(3), 652-660. https://doi.org/10.1016/j.kint.2022.05.015

Chronic kidney disease (CKD) is associated with increased risk of baseline mortality and severe COVID-19, but analyses across CKD stages, and comorbidities are lacking. In prevalent and incident CKD, we investigated comorbidities, baseline risk, COVI... Read More about A retrospective cohort study predicting and validating impact of the COVID-19 pandemic in individuals with chronic kidney disease.

Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing (2022)
Journal Article
Fallowfield, L., Solis-Trapala, Solis-Trapala, I., Starkings, R., May, S., Matthews, L., …Jenkins, V. (2022). Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing. British Journal of Cancer, 127, 1116-1122. https://doi.org/10.1038/s41416-022-01871-x

Background Mainstreaming of germline testing demands that all healthcare professionals have good communication skills, but few have genetic testing and counselling experience. We developed and evaluated educational workshops-Talking about Risk & Unce... Read More about Talking about Risk, UncertaintieS of Testing IN Genetics (TRUSTING): development and evaluation of an educational programme for healthcare professionals about BRCA1 & BRCA2 testing.

PREDICTING THE RISK OF FALLS IN PATIENTS WITH AN INDICATION FOR ANTIHYPERTENSIVE TREATMENT: DEVELOPMENT AND VALIDATION OF THE STRATIFY-FALLS PREDICTION MODEL (2022)
Presentation / Conference
Archer, L., Koshiaris, C., Snell Ie, K., Riley, R. D., Stevens, R., Hobbs, F. R., …Sheppard, J. P. (2022, June). PREDICTING THE RISK OF FALLS IN PATIENTS WITH AN INDICATION FOR ANTIHYPERTENSIVE TREATMENT: DEVELOPMENT AND VALIDATION OF THE STRATIFY-FALLS PREDICTION MODEL. Poster presented at 31st meeting of the European Society of Hepertension (EHS), Athens, Greece

Objective: Falls are one of the most common side effects associated with antihypertensive medication. In patients at high risk of falls, the additional risk of harm from medication may outweigh the potential benefits in terms of cardiovascular risk r... Read More about PREDICTING THE RISK OF FALLS IN PATIENTS WITH AN INDICATION FOR ANTIHYPERTENSIVE TREATMENT: DEVELOPMENT AND VALIDATION OF THE STRATIFY-FALLS PREDICTION MODEL.

Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis (2022)
Journal Article
Mamas, M., Kastora, S. L., Pana, T. A., Sarwar, Y., & Myint, P. K. (2022). Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis. Molecular Diagnosis and Therapy, 26, 369-382. https://doi.org/10.1007/s40291-022-00597-z

BACKGROUND AND OBJECTIVE: Breast cancer is the leading cause of cancer-related mortality amongst women. One of the most common chemotherapeutic agents used to treat breast cancer, anthracyclines, are associated with anthracycline-induced cardiotoxici... Read More about Biomarker Determinants of Early Anthracycline-Induced Left Ventricular Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis.

Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality (2022)
Journal Article
Mamas, Stickels, C. P., Nadarajah, R., Gale, C. P., Jiang, H., Sharkey, K. J., …Erhun, F. (2022). Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality. BMJ Open, 12(6), Article ARTN e059309. https://doi.org/10.1136/bmjopen-2021-059309

OBJECTIVES: To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect National Health Service (NHS) England waiting list duration and associated mortality. DESIGN: We constructed a mathemat... Read More about Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality.

Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial (2022)
Journal Article
Rimmer, M., Elfaki, N., Dunlop, C., Coleburt, D., Cowan, N., Raglan, O., …Al Wattar, B. (2022). Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial. BMJ Open, 12(6), Article e058610. https://doi.org/10.1136/bmjopen-2021-058610

Introduction A journal club (JC) is a commonly used medical educational tool. Videoconferencing technology can facilitate the delivery of JCs, however, there remains no evidence on the role of web-based virtual JCs in promoting the acquisition and re... Read More about Effectiveness of a web-based virtual journal club to promote medical education (Web-Ed): protocol of a multicentre pragmatic randomised trial.