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All Outputs (623)

Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment? (2023)
Journal Article
Nicolson, P. J. A., & Holden, M. A. (2023). Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment?. Current Treatment Options in Rheumatology, 9(3), 120-131. https://doi.org/10.1007/s40674-023-00208-w

Purpose of review: Patient-centred care for people with osteoarthritis requires shared decision making. Understanding and considering patients’ preferences for osteoarthritis treatments is central to this. In this narrative review, we present an over... Read More about Patient Preferences and Osteoarthritis Care: What Do We Know About What Patients Want from Osteoarthritis Treatment?.

EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative synthesis. (2023)
Journal Article
May, C. R., Chew-Graham, C. A., Gallacher, K. I., Gravenhorst, K. C., Mair, F. S., Nolte, E., & Richardson, A. (in press). EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative synthesis. NIHR Open Research, 3, 31. https://doi.org/10.3310/nihropenres.13411.1

BackgroundThe workload health and social care service users and caregivers take on, and their capacity to do this work is important. It may play a key part in shaping the implementation of innovations in health service delivery and organisation; the... Read More about EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative synthesis..

Exploring the treatment burden of disease modifying anti rheumatic drug monitoring in people with rheumatoid arthritis (2023)
Journal Article
Ryan, S., Bullock, L., Manning, F., Chew-Graham, C. A., & Paskins, Z. (in press). Exploring the treatment burden of disease modifying anti rheumatic drug monitoring in people with rheumatoid arthritis. Rheumatology Advances in Practice, 7(2), Article rkad054. https://doi.org/10.1093/rap/rkad054

Objectives People with rheumatoid arthritis (RA) taking disease-modifying anti-rheumatic drugs (DMARDs) require safety monitoring to identify potential side-effects. This study aimed to explore patients’ and family members’ perspectives on DMARD moni... Read More about Exploring the treatment burden of disease modifying anti rheumatic drug monitoring in people with rheumatoid arthritis.

Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo (2023)
Journal Article
Nafchi, N. A. M., Chilcott, E. M., Brown, S., Fuller, H. R., Bowerman, M., & Yáñez-Muñoz, R. J. (2023). Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo. Gene Therapy, https://doi.org/10.1038/s41434-023-00406-0

Spinal muscular atrophy (SMA) is a neuromuscular disease particularly characterised by degeneration of ventral motor neurons. Survival motor neuron (SMN) 1 gene mutations cause SMA, and gene addition strategies to replace the faulty SMN1 copy are a t... Read More about Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo.

Risk of Venous Thromboembolism With Gout Flares (2023)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (2023). Risk of Venous Thromboembolism With Gout Flares. Arthritis and Rheumatology, 75(9), 1638-1647. https://doi.org/10.1002/art.42480

ObjectivePrevious studies demonstrated that the risk of venous thromboembolism (VTE) is increased in patients with gout, but not whether there was a temporal association between gout flare and VTE. This study was undertaken to evaluate potential temp... Read More about Risk of Venous Thromboembolism With Gout Flares.

Ethnic Disparities in ST-Segment Elevation Myocardial Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors: A Nationwide Cohort Study (2023)
Journal Article
Weight, N., Moledina, S., Sun, L., Kragholm, K., Freeman, P., Diaz-Arocutipa, C., …Mamas, M. A. (in press). Ethnic Disparities in ST-Segment Elevation Myocardial Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors: A Nationwide Cohort Study. Angiology, https://doi.org/10.1177/00033197231182555

Trials suggest patients with ST-elevation myocardial infarction (STEMI) without ‘standard modifiable cardiovascular risk factors’ (SMuRFs) have poorer outcomes, but the role of ethnicity has not been investigated. We analyzed 118,177 STEMI patients u... Read More about Ethnic Disparities in ST-Segment Elevation Myocardial Infarction Outcomes and Processes of Care in Patients With and Without Standard Modifiable Cardiovascular Risk Factors: A Nationwide Cohort Study.

Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria (2023)
Journal Article
Nguyen, S. T., Du, D., Wychrij, D., Cain, M. D., Wu, Q., Klein, R. S., …Goldberg, D. E. (2023). Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America, 120(26), Article e2306318120. https://doi.org/10.1073/pnas.2306318120

Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication of malaria. HRPII has been sh... Read More about Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria.

Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis (2023)
Journal Article
Holden, M. A., Hattle, M., Runhaar, J., Riley, R. D., Healey, E. L., Quicke, J., …Exercise Collaborative, O. T. B. (2023). Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis. The Lancet Rheumatology, 5(7), e386-e400. https://doi.org/10.1016/S2665-9913%2823%2900122-4

Background Many international clinical guidelines recommend therapeutic exercise as a core treatment for knee and hip osteoarthritis. We aimed to identify individual patient-level moderators of the effect of therapeutic exercise for reducing pain an... Read More about Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis.

Supported self-management for all with musculoskeletal pain: an inclusive approach to intervention development: the EASIER study (2023)
Journal Article
Healey, E. L., Lewis, M., Corp, N., Shivji, N. A., van der Windt, D. A., Babatunde, O. O., …Protheroe, J. (2023). Supported self-management for all with musculoskeletal pain: an inclusive approach to intervention development: the EASIER study. BMC Musculoskeletal Disorders, 24(1), Article 474. https://doi.org/10.1186/s12891-023-06452-4

Background Supported self-management interventions for patients with musculoskeletal (MSK) conditions may not adequately support those with limited health literacy, leading to inequalities in care and variable outcomes. The aim of this study was to... Read More about Supported self-management for all with musculoskeletal pain: an inclusive approach to intervention development: the EASIER study.

Research priorities regarding the use of bisphosphonates for osteoporosis: a UK priority setting exercise (2023)
Journal Article
Paskins, Z., Moult, A., Corp, N., Bastounis, A., Davis, S., Narayanasamy, M. J., …Sahota, O. (2023). Research priorities regarding the use of bisphosphonates for osteoporosis: a UK priority setting exercise. Osteoporosis International, 10.1007/s00198-023-06806-7. https://doi.org/10.1007/s00198-023-06806-7

Worldwide, many people who would benefit from osteoporosis drugs are not offered or receiving them, resulting in an osteoporosis care gap. Adherence with bisphosphonates is particularly low. This study aimed to identify stakeholder research prioritie... Read More about Research priorities regarding the use of bisphosphonates for osteoporosis: a UK priority setting exercise.

Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis. (2023)
Journal Article
Hussain, B., Markson, F., Mamas, M. A., Alraies, C., Aggarwal, V., Kumar, G., …Paul, T. K. (2023). Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis. Current Problems in Cardiology, 48(10), Article 101866. https://doi.org/10.1016/j.cpcardiol.2023.101866

Systemic sarcoidosis can lead to heart failure, conduction abnormalities and ventricular arrhythmias although data on concomitant valvular heart disease (VHD) is limited. We reported the prevalence and outcomes of VHD in systemic sarcoidosis. A retro... Read More about Effects of Valvular Heart Disease on Clinical Outcomes in Sarcoidosis..

Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial. (2023)
Journal Article
Coles, C. E., Haviland, J. S., Kirby, A. M., Griffin, C. L., Sydenham, M. A., Titley, J. C., …Bliss, J. M. (in press). Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial. Lancet, 401(10394), 2124-2137. https://doi.org/10.1016/S0140-6736%2823%2900619-0

A tumour-bed boost delivered after whole-breast radiotherapy increases local cancer-control rates but requires more patient visits and can increase breast hardness. IMPORT HIGH tested simultaneous integrated boost against sequential boost with the ai... Read More about Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial..

Effect of Milk Protein and Whey Permeate in Large-Quantity Lipid-Based Nutrient Supplement on Early Child Development among Children with Stunting: A Randomized 2 × 2 Factorial Trial in Uganda (2023)
Journal Article
Mbabazi, J., Pesu, H., Mutumba, R., McCray, G., Michaelsen, K. F., Ritz, C., …Olsen, M. F. (2023). Effect of Milk Protein and Whey Permeate in Large-Quantity Lipid-Based Nutrient Supplement on Early Child Development among Children with Stunting: A Randomized 2 × 2 Factorial Trial in Uganda. Nutrients, 15(12), Article 2659. https://doi.org/10.3390/nu15122659

Stunting affects 22% children globally, putting them at risk of adverse outcomes including delayed development. We investigated the effect of milk protein (MP) vs. soy and whey permeate (WP) vs. maltodextrin in large-quantity, lipid-based nutrient su... Read More about Effect of Milk Protein and Whey Permeate in Large-Quantity Lipid-Based Nutrient Supplement on Early Child Development among Children with Stunting: A Randomized 2 × 2 Factorial Trial in Uganda.

Predicting antipsychotic-induced weight gain in first episode psychosis – a field-wide systematic review and meta-analysis of non-genetic prognostic factors (2023)
Journal Article
Fitzgerald, I., Sahm, L. J., Byrne, A., O’Connell, J., Ensor, J., Dhubhlaing, C. N., …Crowley, E. K. (in press). Predicting antipsychotic-induced weight gain in first episode psychosis – a field-wide systematic review and meta-analysis of non-genetic prognostic factors. European Psychiatry, 1-39. https://doi.org/10.1192/j.eurpsy.2023.2417

Whether non-genetic prognostic factors significantly influence the variable prognosis of antipsychotic-induced weight gain (AIWG) has not yet been systematically explored.

Intravenous iron therapy among patients with heart failure and iron deficiency: An updated meta-analysis of randomized controlled trials. (2023)
Journal Article
Hamed, M., Elseidy, S. A., Ahmed, A., Thakker, R., Mansoor, H., Khalili, H., …Elbadawi, A. (2023). Intravenous iron therapy among patients with heart failure and iron deficiency: An updated meta-analysis of randomized controlled trials. Heliyon, 9(6), Article e17245. https://doi.org/10.1016/j.heliyon.2023.e17245

Background: Randomized clinical trials (RCTs) evaluating the role of intravenous (IV) iron administration in patients with heart failure (HF) and iron deficiency (ID) have yielded inconsistent results. Methods: Electronic search of MEDLINE, EMBASE... Read More about Intravenous iron therapy among patients with heart failure and iron deficiency: An updated meta-analysis of randomized controlled trials..