Zoe Paskins z.paskins@keele.ac.uk
Research priorities regarding the use of bisphosphonates for osteoporosis: a UK priority setting exercise
Paskins, Zoe; Moult, Alice; Corp, Nadia; Bastounis, Anastasios; Davis, Sarah; Narayanasamy, Melanie Jay; Griffin, Jill; Gittoes, Neil; Leonardi-Bee, Jo; Langley, Tessa; Bishop, Simon; Sahota, Opinder
Authors
Alice Moult a.moult@keele.ac.uk
Nadia Corp n.corp@keele.ac.uk
Anastasios Bastounis
Sarah Davis
Melanie Jay Narayanasamy
Jill Griffin
Neil Gittoes
Jo Leonardi-Bee
Tessa Langley
Simon Bishop
Opinder Sahota
Abstract
Worldwide, many people who would benefit from osteoporosis drugs are not offered or receiving them, resulting in an osteoporosis care gap. Adherence with bisphosphonates is particularly low. This study aimed to identify stakeholder research priorities relating to bisphosphonate treatment regimens for prevention of osteoporotic fractures. A three-step approach based on the James Lind Alliance methodology for identification and prioritisation of research questions was used. Research uncertainties were gathered from a large programme of related research studies about bisphosphonate regimens and from recent published international clinical guidelines. Clinical and public stakeholders refined the list of uncertainties into research questions. The third step prioritised the questions using a modified nominal group technique. In total, 34 draft uncertainties were finalised into 33 research questions by stakeholders. The top 10 includes questions relating to which people should be offered intravenous bisphosphonates first line (1); optimal duration of treatment (2); the role of bone turnover markers in treatment breaks (3); support patient need for medicine optimisation (4); support primary care practitioner need regarding bisphosphonates (5); comparing zoledronate given in community vs hospital settings (6); ensuring quality standards are met (7); the long-term model of care (8); best bisphosphonate for people aged under 50 (9); and supporting patient decision-making about bisphosphonates (10). This study reports, for the first time, topics of importance to stakeholders in the research of bisphosphonate osteoporosis treatment regimens. These findings have implications for research into implementation to address the care gap and education of healthcare professionals. Using James Lind Alliance methodology, this study reports prioritised topics of importance to stakeholders in the research of bisphosphonate treatment in osteoporosis. The priorities address how to better implement guidelines to address the care gap, understanding patient factors influencing treatment selection and effectiveness, and how to optimise long-term care. [Abstract copyright: © 2023. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.]
Journal Article Type | Article |
---|---|
Acceptance Date | May 23, 2023 |
Online Publication Date | Jun 9, 2023 |
Publication Date | Jun 9, 2023 |
Deposit Date | Jun 12, 2023 |
Publicly Available Date | Jun 10, 2024 |
Journal | Osteoporosis International |
Print ISSN | 0937-941X |
Electronic ISSN | 1433-2965 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Pages | 10.1007/s00198-023-06806-7 |
DOI | https://doi.org/10.1007/s00198-023-06806-7 |
Keywords | Research priorities, Bisphosphonates, Stakeholder, Osteoporosis |
Additional Information | Received: 9 August 2022; Accepted: 23 May 2023; First Online: 9 June 2023; : ; : ZP reports paid non-promotional consultancy for UCB. AM, NC,AB, MN, JG, NG, JLB, TL, SB, and OS declare that they have no conflicts of interest. SD reports a grant from Roche Diagnostics to her employing institution to fund research into the cost-effectiveness of using a biomarker to monitor response to treatment with antifracture medication. |
Files
This file is under embargo until Jun 10, 2024 due to copyright reasons.
Contact h.reidy@keele.ac.uk to request a copy for personal use.
You might also like
Osteoarthritis year in review 2022: rehabilitation
(2022)
Journal Article
Downloadable Citations
About Keele Repository
Administrator e-mail: research.openaccess@keele.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search