All Outputs (5)

Use of nanoparticles to improve the therapeutic index of navitoclax (2022)
Thesis
Alrosan, K. J. J. A. (2022). Use of nanoparticles to improve the therapeutic index of navitoclax. (Thesis). Keele University

Ovarian cancer is considered a major health problem in women. The chemotherapeutic drugs that are used often are inadequate due to the development of drug resistance. This s related to many causes, and one of them is an evasion of apoptosis. One of t... Read More about Use of nanoparticles to improve the therapeutic index of navitoclax.

Translational studies to support the use of pitavastatin as a cancer therapeutic (2020)
Thesis
Jawad, M. J. (2020). Translational studies to support the use of pitavastatin as a cancer therapeutic. (Thesis). Keele University

Ovarian cancer is the fifth leading cause of death associated with cancer. Initially, the disease responds to surgical cytoreduction, followed by chemotherapy. The primary response rate for chemotherapy is about 80%. Unfortunately, most patients rela... Read More about Translational studies to support the use of pitavastatin as a cancer therapeutic.

Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells (2019)
Thesis
Ibrahim, . S. L. (2019). Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413776

Breast cancer is considered the most frequently diagnosed cancer in women and the second most common type of cancer causing deaths among women. It is accounts 25% of all female cancers. It is expected about 1 in 8 women will develop this disease duri... Read More about Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells.

Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy (2018)
Thesis
Abo Donia, M. N. A. (2018). Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410399

Ovarian cancer is a complex disease characterized by low incidence, accounting for about 4% of cancer diagnoses in women, but with rapid progression and higher mortality rate than any other gynecological malignancy. Approximately 70 % of the cases ar... Read More about Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy.

Epigenomic changes associated with high-grade non-muscle invasive bladder cancer (2016)
Thesis
Kitchen, M. O. (2016). Epigenomic changes associated with high-grade non-muscle invasive bladder cancer. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/409152

The development and progression of high-grade non-muscle invasive bladder cancer (NMIBC) results from a complex interplay of environmental and heritable risk factors, including those that impact upon genetic and epigenetic pathways. Recent studies ha... Read More about Epigenomic changes associated with high-grade non-muscle invasive bladder cancer.