All Outputs (99)

Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study (2013)
Journal Article
Frisher, M., Martino, O. I., Bashford, J., Crome, I., & Croft, P. (in press). Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study. The European Journal of Psychiatry, 27(4), 240-247. https://doi.org/10.4321/s0213-61632013000400002

Background and Objectives: While several studies have indicated a link between illicit drug use and the development of psychosis, the confounding role of pre-existing psychiatric illness is unclear. This study controls for this factor to a greater ex... Read More about Incidence of psychoses among drug dependent patients in primary care with no psychiatric history: a retrospective observational matched-cohort study.

aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors (2013)
Journal Article
(2013). aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors. BioMed Research International, 729281 - ?. https://doi.org/10.1155/2013/729281

Human embryonic stem cells (hESCs) have great potential for clinical therapeutic use. However, relatively little is known of the mechanisms which dictate their specificity of adhesion to substrates through adhesion proteins including integrins. Previ... Read More about aV ß5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors.

A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data (2013)
Journal Article
(2013). A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data. PloS one, e83773 - e83773. https://doi.org/10.1371/journal.pone.0083773

Background: The clinical investigation of human brain tumors often starts with a non-invasive imaging study, providing information about the tumor extent and location, but little insight into the biochemistry of the analyzed tissue. Magnetic Resonanc... Read More about A novel semi-supervised methodology for extracting tumor type-specific MRS sources in human brain data.

Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro (2013)
Journal Article
(2013). Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro. NeuroReport, 1041 -1046. https://doi.org/10.1097/WNR.0000000000000071

Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization,... Read More about Nicotinamide promotes neuronal differentiation of mouse embryonic stem cells in vitro.

Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties (2013)
Journal Article
Byrne, T. M., Coker, V. S., Cespedes, E., Wincott, P. L., Vaughan, D. J., Pattrick, R. A. D., …Telling, N. D. (2014). Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties. Advanced functional materials, 24(17), 2518-2529. https://doi.org/10.1002/adfm.201303230

The magnetic moments of magnetite nanoparticles are dramatically enhanced through the addition of zinc in a microbiologically driven synthesis procedure. The particles are produced through the reduction of Fe(III)-compounds containing Zn(II) by the i... Read More about Biosynthesis of Zinc Substituted Magnetite Nanoparticles with Enhanced Magnetic Properties.

The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods (2013)
Journal Article
Arabshahi, H. J., Leung, E., Barker, D., & Reynisson, J. (2014). The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods. MedChemComm, 5(2), 186. https://doi.org/10.1039/c3md00320e

The chemical space surrounding a class of thieno[2,3-b]pyridines was investigated by testing their commercially available derivatives against the NCI60 panel of human tumour cell lines. The results from the nineteen analogues revealed that ortho- and... Read More about The development of thieno[2,3-b]pyridine analogues as anticancer agents applying in silico methods.

CuI-catalyzed cycloisomerization of propargyl amides (2013)
Journal Article
Moran, W., & Alhalib, A. (2014). CuI-catalyzed cycloisomerization of propargyl amides. Organic and Biomolecular Chemistry, 12(5), 795-800. https://doi.org/10.1039/c3ob42030b

The synthesis of substituted dihydrooxazoles by the CuI-catalyzed cycloisomerization of terminal propargyl amides is reported. The reaction has been shown to have good substrate scope and experiments to delineate the mechanism have been performed. Su... Read More about CuI-catalyzed cycloisomerization of propargyl amides.

Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice (2013)
Journal Article
Zhang, L., Sinclair, R., Selman, C., Mitchell, S., Morgan, D., Clapham, J. C., & Speakman, J. R. (2014). Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice. Obesity, 22(3), 681-690. https://doi.org/10.1002/oby.20418

Objective The melanin-concentrating hormone (MCH) is a centrally acting peptide implicated in the regulation of energy homeostasis and body weight, although its role in glucose homeostasis is uncertain. Our objective was to determine effects of MCHR... Read More about Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet‐induced obese mice.

Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival (2013)
Journal Article
Davies, S. (2013). Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. Journal of the American Society of Nephrology, 2071 - 2080. https://doi.org/10.1681/ASN.2013030314

Systemic inflammation, as evidenced by elevated inflammatory cytokines, is a feature of advanced renal failure and predicts worse survival. Dialysate IL-6 concentrations associate with variability in peritoneal small solute transport rate (PSTR), whi... Read More about Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival.

The effects of surgical lengthening of hamstring muscles in children with cerebral palsy – The consequences of pre-operative muscle length measurement (2013)
Journal Article
Laracca, E., Stewart, C., Postans, N., & Roberts, A. (2014). The effects of surgical lengthening of hamstring muscles in children with cerebral palsy – The consequences of pre-operative muscle length measurement. Gait and Posture, 39(3), 847-851. https://doi.org/10.1016/j.gaitpost.2013.11.010

The effect of a thieno[2,3-b]pyridine PLC-γ inhibitor on the proliferation, morphology, migration and cell cycle of breast cancer cells (2013)
Journal Article
Leung, E., Hung, J. M., Barker, D., & Reynisson, J. (in press). The effect of a thieno[2,3-b]pyridine PLC-γ inhibitor on the proliferation, morphology, migration and cell cycle of breast cancer cells. MedChemComm, 5(1), 99-106. https://doi.org/10.1039/c3md00290j

3-Amino-N-(3-chlorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (compound 1) is a putative phosphoinositide specific-phospholipase C-γ (PLC-γ) enzyme inhibitor. This enzyme is a plausible anticancer target linked to cell motil... Read More about The effect of a thieno[2,3-b]pyridine PLC-γ inhibitor on the proliferation, morphology, migration and cell cycle of breast cancer cells.

Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium (2013)
Journal Article
(2013). Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium. PLOS pathogens a peer-reviewed open-access journal published by the Public Library of Science, e1003790 -?. https://doi.org/10.1371/journal.ppat.1003790

A new generation of strategies is evolving that aim to block malaria transmission by employing genetically modified vectors or mosquito pathogens or symbionts that express anti-parasite molecules. Whilst transgenic technologies have advanced rapidly,... Read More about Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium.

Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. (2013)
Journal Article
Fisher, N., Hilton-Bolt, T., G Edwards, M., J Haxton, K., McKenzie, M., Allin, S. M., & Richardson, A. (2014). Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor. ACS medicinal chemistry letters, 5(1), 34-39. https://doi.org/10.1021/ml4003106

Autotaxin is an extracellular phospholipase D that catalyzes the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Dendrimer Conjugate of [4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor..

Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases (2013)
Journal Article
Fuller, H. R., Humphrey, E. L., & Morris, G. E. (2013). Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases. Future Medicinal Chemistry, 5(17), 2091-2101. https://doi.org/10.4155/fmc.13.165

There are several lines of laboratory-based evidence emerging to suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the... Read More about Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases.

Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method (2013)
Journal Article
Guan, G., Li, C., Ling, Y., Yang, Y., Vorstius, J. B., Keatch, R. P., …Huang, Z. (2013). Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method. Journal of Biomedical Optics, 18(11), 111417. https://doi.org/10.1117/1.jbo.18.11.111417

Damage of collagen fibers in tendons is often directly related to changes in a tendon’s mechanical properties. Direct quantitative elasticity measurement of tendons will provide important information in tendon dysfunction diagnosis and treatment asse... Read More about Quantitative evaluation of degenerated tendon model using combined optical coherence elastography and acoustic radiation force method.

Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro (2013)
Journal Article
(2013). Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro. Antimicrobial Agents and Chemotherapy, 5612-5618. https://doi.org/10.1128/AAC.01421-13

Rilpivirine is a nonnucleoside reverse transcriptase inhibitor approved for treatment of HIV-1 infection in antiretroviral-naive adult patients. Potential interactions with drug transporters have not been fully investigated. Transport by and inhibiti... Read More about Rilpivirine inhibits drug transporters ABCB1, SLC22A1, and SLC22A2 in vitro.

Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases (2013)
Journal Article
Wright, K. T., Mennan, C., Fox, H., Richardson, J. B., Banerjee, R., & Roberts, S. (2013). Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regenerative Medicine, 8(6), 699 - 709. https://doi.org/10.2217/rme.13.67

AIM: Autologous chondrocyte implantation (ACI) is used worldwide for the treatment of cartilage defects. This study has aimed to assess for the first time the cells that are contained within human ACI repair tissues several years post-treatment. We h... Read More about Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases.

Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial (2013)
Journal Article
Maripuri, S. N., Gallacher, P. D., Bridgens, J., Kuiper, J. H., & Kiely, N. T. (2013). Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial. The Bone & Joint Journal, 95-B(11), 1570-1574. https://doi.org/10.1302/0301-620x.95b11.31899

We undertook a randomised clinical trial to compare treatment times and failure rates between above- and below-knee Ponseti casting groups. Eligible children with idiopathic clubfoot, treated using the Ponseti method, were randomised to either below-... Read More about Ponseti casting for club foot – above- or below-knee?: A prospective randomised clinical trial.

Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology (2013)
Journal Article
Guan, J., Han, J., Zhang, D., Chu, C., Liu, H., Sun, J., …Zhang, T. (2014). Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology. European Journal of Pharmaceutics and Biopharmaceutics, 86(3), 376-382. https://doi.org/10.1016/j.ejpb.2013.10.008

The aim of this study was to design a silica-supported solid dispersion of a water-insoluble drug, glyburide, to increase its dissolution rate and oral absorption using supercritical fluid (SCF) technology. DSC and PXRD results indicated that the enc... Read More about Increased dissolution rate and oral bioavailability of hydrophobic drug glyburide tablets produced using supercritical CO2 silica dispersion technology.

Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls (2013)
Journal Article
(2013). Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls. BMC Public Health, https://doi.org/10.1186/1471-2458-13-1003

Background Many children do not meet current UK physical activity (PA) guidelines. Girls are less active than boys throughout childhood, and the age-related decline in PA, particularly from early adolescence, is steeper for girls than for boys. Danc... Read More about Bristol girls dance project (BGDP): protocol for a cluster randomised controlled trial of an after-school dance programme to increase physical activity among 11–12 year old girls.