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EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS). (2024)
Journal Article
Richter, M., Agren, P.-H., Besse, J.-L., Coester, M., Kofoed, H., Maffulli, N., …Johansen, J. K. (in press). EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS). Foot and Ankle Surgery, 30(4), 294-298. https://doi.org/10.1016/j.fas.2024.03.009

The Score Committee of the European Foot and Ankle Society (EFAS) developed, validated, and published the EFAS Score in 13 languages. Currently, the Danish version completed data acquisition and underwent further validation. The data were collected p... Read More about EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS)..

Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues (2024)
Journal Article
Everett, J., Brooks, J., Tjendana Tjhin, V., Lermyte, F., Hands-Portman, I., Plascencia-Villa, G., …Telling, N. D. (2024). Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues. ACS chemical neuroscience, 15(7), 1469–1483. https://doi.org/10.1021/acschemneuro.3c00756

The accumulation of amyloid plaques and increased brain redox burdens are neuropathological hallmarks of Alzheimer’s disease. Altered metabolism of essential biometals is another feature of Alzheimer’s, with amyloid plaques representing sites of dist... Read More about Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues.

Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells (2024)
Journal Article
Storey, E., Holt, I., Brown, S., Synowsky, S., Shirran, S., & Fuller, H. (2024). Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells. Neuromuscular Disorders, 38, 26-41. https://doi.org/10.1016/j.nmd.2024.03.006

LMNA-related congenital muscular dystrophy (L-CMD) is caused by mutations in the LMNA gene, encoding lamin A/C. To further understand the molecular mechanisms of L-CMD, proteomic profiling using DIA mass spectrometry was conducted on immortalized myo... Read More about Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells.

Management of rotator cuff injuries using allogenic platelet-rich plasma (2024)
Journal Article
Gupta, A., Migliorini, F., & Maffulli, N. (in press). Management of rotator cuff injuries using allogenic platelet-rich plasma. Journal of Orthopaedic Surgery and Research, 19(1), Article 165. https://doi.org/10.1186/s13018-024-04657-4

Rotator cuff injuries are a major cause of shoulder pain, affecting the quality of life and producing a significant burden on healthcare systems. Conservative management modalities are prioritized, resorting to surgery only when required. The field o... Read More about Management of rotator cuff injuries using allogenic platelet-rich plasma.

Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase (2024)
Journal Article
Tishova, Y., Kalinchenko, S., Mskhalaya, G., Hackett, G., Livingston, M., König, C., …Ramachandran, S. (2024). Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase. Diabetes, Obesity and Metabolism, 26(6), 2147-2157. https://doi.org/10.1111/dom.15520

Aims
To describe changes in homeostasis model assessment of insulin resistance index (HOMA-IR) following testosterone therapy in men with hypogonadism and metabolic syndrome (MetS).

Materials and Methods
A randomized, placebo-controlled, double-... Read More about Testosterone therapy reduces insulin resistance in men with adult‐onset testosterone deficiency and metabolic syndrome. Results from the Moscow Study, a randomized controlled trial with an open‐label phase.

Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. (2024)
Journal Article
Ali, A. M. S., Gul, W., Sen, J., Hewitt, S.-J., Olubajo, F., & McMahon, C. (in press). Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study. Clinical Neurology and Neurosurgery, 239, Article 108215. https://doi.org/10.1016/j.clineuro.2024.108215

Assessment of the pupillary light reflex (PLR) is key in intensive care monitoring of neurosurgical patients, particularly for monitoring intracranial pressure (ICP). Quantitative pupillometry using a handheld pupillometer is a reliable method for PL... Read More about Evaluating the utility of quantitative pupillometry in a neuro-critical care setting for the monitoring of intracranial pressure: A prospective cohort study..

Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals (2024)
Journal Article
Simkins, J., Holden, M. A., Babatunde, O., White, S., Nicholls, E., Long, A., …O’Brien, N. (2024). Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals. Musculoskeletal Care, 22(1), Article e1873. https://doi.org/10.1002/msc.1873

Introduction
Osteoarthritis is the commonest form of chronic joint pain, which patients often self-manage before seeking healthcare advice. Patients frequently seek advice from community pharmacies, and a recent policy has recommended integrating co... Read More about Exploring the potential extended role of community pharmacy in the management of osteoarthritis: A multi‐methods study with pharmacy staff and other healthcare professionals.

All-epiphyseal anterior cruciate ligament reconstruction yields superior sports performances than the trans-epiphyseal technique in skeletally immature patients: a systematic review (2024)
Journal Article
Migliorini, F., Pilone, M., Memminger, M. K., Eschweiler, J., Giorgino, R., & Maffulli, N. (in press). All-epiphyseal anterior cruciate ligament reconstruction yields superior sports performances than the trans-epiphyseal technique in skeletally immature patients: a systematic review. Journal of Orthopaedics and Traumatology, 25(1), Article 7. https://doi.org/10.1186/s10195-024-00751-9

Background: Anterior cruciate ligament (ACL) tears in skeletally immature patients are increasingly common. Evidence comparing the outcomes of all-epiphyseal versus trans-epiphyseal ACL reconstruction in skeletally immature patients is limited, and t... Read More about All-epiphyseal anterior cruciate ligament reconstruction yields superior sports performances than the trans-epiphyseal technique in skeletally immature patients: a systematic review.

Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. (2024)
Journal Article
Okoro, T., Wan, M., Mukabeta, T. D., Malev, E., Gross, M., Williams, C., …Murnaghan, J. (in press). Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty. World Journal of Orthopedics, 15(2), 170-179. https://doi.org/10.5312/wjo.v15.i2.170

Prophylactic antibiotics have significantly led to a reduction in the risk of post-operative surgical site infections (SSI) in orthopaedic surgery. The aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,... Read More about Assessment of the effectiveness of weight-adjusted antibiotic administration, for reduced duration, in surgical prophylaxis of primary hip and knee arthroplasty..

The clinical potential of meniscal progenitor cells (2024)
Journal Article
Yan, W., Wang, J., Fan, P., Roberts, S., Wright, K., & Zhang, Z. (2024). The clinical potential of meniscal progenitor cells. Journal of Cartilage & Joint Preservation (JCJP), 100166. https://doi.org/10.1016/j.jcjp.2024.100166

Introduction
The meniscus is an important cushioning structure of the knee joint, the maintenance of its normal structure and function plays a crucial role in protecting the joint from early degeneration. Stem/pro... Read More about The clinical potential of meniscal progenitor cells.

Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men (2024)
Journal Article
Hackett, G., Mann, A., Haider, A., Haider, K. S., Desnerck, P., König, C. S., …Ramachandran, S. (in press). Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men. The World Journal of Men's Health, 42, https://doi.org/10.5534/wjmh.230239

While testosterone therapy can improve the various pathologies associated with adult-onset testosterone deficiency (TD), Summary of Product Characteristics (SPC) of five testosterone preparations caution that treatment may be associated with hyperten... Read More about Testosterone Replacement Therapy: Effects on Blood Pressure in Hypogonadal Men.

The pandemic is gone but its consequences are here to stay: avascular necrosis following corticosteroids administration for severe COVID-19 (2024)
Journal Article
Migliorini, F., Maffulli, N., Shukla, T., D’Ambrosi, R., Singla, M., Vaish, A., & Vaishya, R. (in press). The pandemic is gone but its consequences are here to stay: avascular necrosis following corticosteroids administration for severe COVID-19. Journal of Orthopaedic Surgery and Research, 19(1), Article 135. https://doi.org/10.1186/s13018-024-04556-8

Background
In patients with COVID-19 infection and respiratory insufficiency, corticosteroid (CCS) administration is recommended. Among the wide range of complications and interactions, time-limited high-dose CCS administration might promote avascul... Read More about The pandemic is gone but its consequences are here to stay: avascular necrosis following corticosteroids administration for severe COVID-19.

Surgical management of chronic Achilles tendon rupture: evidence-based guidelines (2024)
Journal Article
Feng, S., Maffulli, N., Oliva, F., Saxena, A., Hao, Y., Hua, Y., …Ma, C. (in press). Surgical management of chronic Achilles tendon rupture: evidence-based guidelines. Journal of Orthopaedic Surgery and Research, 19(1), Article 132. https://doi.org/10.1186/s13018-024-04559-5

Background
Chronic Achilles tendon ruptures (CATR) often require surgical intervention to restore function. Despite numerous treatment modalities available, the optimal management strategy remains controversial given the limited high-quality evidenc... Read More about Surgical management of chronic Achilles tendon rupture: evidence-based guidelines.

Functional alignment in robotic-assisted total knee arthroplasty: a systematic review. (2024)
Journal Article
Migliorini, F., Pilone, M., Schäfer, L., Simeone, F., Bell, A., & Maffulli, N. (in press). Functional alignment in robotic-assisted total knee arthroplasty: a systematic review. Archives of Orthopaedic and Trauma Surgery, 10.1007/s00402-023-05195-0. https://doi.org/10.1007/s00402-023-05195-0

The present study systematically reviewed current evidence on functional alignment (FA) in robotic total knee arthroplasty (TKA), discussing advantages and limitations, possible pitfalls, and prospects. This study was conducted according to the 2020... Read More about Functional alignment in robotic-assisted total knee arthroplasty: a systematic review..

Endoscopic peroneus brevis tendon transfer for chronic ruptures of the Achilles tendon: surgical technique (2024)
Journal Article
Poeta, N., Maffulli, N., Bucolo, F., Charpail, C., Migliorini, F., & Guillo, S. (in press). Endoscopic peroneus brevis tendon transfer for chronic ruptures of the Achilles tendon: surgical technique. Journal of Orthopaedic Surgery and Research, 19(1), Article 131. https://doi.org/10.1186/s13018-024-04534-0

Chronic Achilles tendon rupture is usually defined as a rupture diagnosed 4–6 weeks after injury. The management of chronic Achilles tendon rupture (CATR) is a topic of hot debate, and no consensus has been achieved. Surgical management of CATR is re... Read More about Endoscopic peroneus brevis tendon transfer for chronic ruptures of the Achilles tendon: surgical technique.

Diagnosis and management of Achilles tendon ailments: the Scottish mist (2024)
Journal Article
Maffulli, N., King, J. B., Migliorini, F., Chan, O., Padhiar, N., & Spiezia, F. (in press). Diagnosis and management of Achilles tendon ailments: the Scottish mist. Journal of Orthopaedic Surgery and Research, 19(1), Article 130. https://doi.org/10.1186/s13018-024-04560-y

The diagnosis and management of Achilles tendon ailments continue to be widely discussed by the scientific community. Also, the nomenclature used to describe the tendinopathic lesion in patients changed over the last decades together with the evoluti... Read More about Diagnosis and management of Achilles tendon ailments: the Scottish mist.

No correlation exists Between Tibial And Femoral Based Measurements Of Patella Alta In A Population with chronic patellofemoral pain or instability undergoing patella distalisation (2024)
Journal Article
Snow, M., Singh, N., Rix, L., & Haikal, M. (2024). No correlation exists Between Tibial And Femoral Based Measurements Of Patella Alta In A Population with chronic patellofemoral pain or instability undergoing patella distalisation. Arthroscopy: The Journal of Arthroscopy and Related Surgery, https://doi.org/10.1016/j.arthro.2024.01.036

Purpose
To investigate if Patellotrochlear index (PTI) predicts patella alta as determined by tibial based methods of Insall Salvati (IS) and Caton Deschamp (CD) in a pathological population (with patellofemoral p... Read More about No correlation exists Between Tibial And Femoral Based Measurements Of Patella Alta In A Population with chronic patellofemoral pain or instability undergoing patella distalisation.

Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples (2024)
Journal Article
Sharifabad, M. E., Eizadi Sharifabad, M., Soucaille, R., Wang, X., Rotherham, M., Loughran, T., …Telling, N. (2024). Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples. ACS Nano, 18(7), 5297-5310. https://doi.org/10.1021/acsnano.3c08955

The study of exogenous and endogenous nanoscale magnetic material in biology is important for developing biomedical nanotechnology as well as for understanding fundamental biological processes such as iron metabolism and biomineralization. Here, we e... Read More about Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples.