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MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. (2013)
Journal Article
Di Leva, G., Garofalo, M., Jeon, Y., Nuovo, G. J., Middleton, J., Secchiero, P., …Croce, C. M. (2013). MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PloS one, 8(6), e67581 - ?. https://doi.org/10.1371/journal.pone.0067581

Lung cancer is the leading cause of cancer mortality in the world today. Although some advances in lung cancer therapy have been made, patient survival is still poor. MicroRNAs (miRNAs) can act as oncogenes or tumor-suppressor genes in human malignan... Read More about MiR-34a/c-Dependent PDGFR-a/ß Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer..

Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury (2013)
Journal Article
Mamas. (2013). Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury. Frontiers in Physiology, 130 - ?. https://doi.org/10.3389/fphys.2013.00130

BACKGROUND: Ventricular tachyarrhythmias are the most common and often the first manifestation of coronary heart disease and lead to sudden cardiac death (SCD). Early detection/identification of acute myocardial ischaemic injury at risk for malignant... Read More about Serum sphingolipids level as a novel potential marker for early detection of human myocardial ischaemic injury.

The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model (2013)
Journal Article
Webb, W. R., Dale, T. P., Lomas, A. J., Zeng, G., Wimpenny, I., El Haj, A. J., …Chen, G. (2013). The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model. Biomaterials, 34(28), 6683-6694. https://doi.org/10.1016/j.biomaterials.2013.05.041

Tendon injuries and defects present a substantial burden to global healthcare economies. There are no synthetic/biosynthesised implants available which can restore full function or match the mechanical properties of native tendon. Therefore, poly(3-h... Read More about The application of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) scaffolds for tendon repair in the rat model.

Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. (2013)
Journal Article
Mennan, C., Wright, K., Bhattacharjee, A., Balain, B., Richardson, J., & Roberts, S. (2013). Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. BioMed Research International, 2013, Article 916136. https://doi.org/10.1155/2013/916136

Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal... Read More about Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord..

The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). The Role of microRNAs in the Tumorigenesis of Ovarian Cancer. Frontiers in oncology, 3, 153 - ?. https://doi.org/10.3389/fonc.2013.00153

Epithelial ovarian cancer (EOC) is a complex disease, with multiple histological subtypes recognized. There have been major advances in the understanding of the cellular and molecular biology of this human malignancy, however the survival rate of wom... Read More about The Role of microRNAs in the Tumorigenesis of Ovarian Cancer..

Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the U.K.: results from the ADVOCATE study (2013)
Journal Article
Jenkins, V., Catt, S., Banerjee, S., Gourley, C., Montes, A., Solis-Trapala, I., …Fallowfield, L. (2013). Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the U.K.: results from the ADVOCATE study. British journal of cancer, 2264 - 2271. https://doi.org/10.1038/bjc.2013.223

BACKGROUND: Most patients presenting with advanced ovarian cancer (AOC) eventually relapse. Symptom palliation, maintenance of quality of life (QoL) and prolongation of life are primary therapeutic goals. METHODS: Sixty-six U.K. oncologists completed... Read More about Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the U.K.: results from the ADVOCATE study.

Controlled cobalt doping in biogenic magnetite nanoparticles (2013)
Journal Article
Byrne, J. M., Coker, V. S., Moise, S., Wincott, P. L., Vaughan, D. J., Tuna, F., …Telling, N. D. (2013). Controlled cobalt doping in biogenic magnetite nanoparticles. Journal of the Royal Society. Interface, 10(83), 20130134. https://doi.org/10.1098/rsif.2013.0134

Cobalt-doped magnetite (CoxFe3 −xO4) nanoparticles have been produced through the microbial reduction of cobalt–iron oxyhydroxide by the bacterium Geobacter sulfurreducens. The materials produced, as measured by superconducting quantum interference d... Read More about Controlled cobalt doping in biogenic magnetite nanoparticles.

Controlled Production of Poly (3-Hydroxybutyrate-co-3-Hydroxyhexanoate) (PHBHHx) Nanoparticles for Targeted and Sustained Drug Delivery (2013)
Journal Article
Heathman, T. R., Webb, W. R., Han, J., Dan, Z., Chen, G. Q., Forsyth, N. R., …Sun, X. (2014). Controlled Production of Poly (3-Hydroxybutyrate-co-3-Hydroxyhexanoate) (PHBHHx) Nanoparticles for Targeted and Sustained Drug Delivery. Journal of Pharmaceutical Sciences, 103(8), 2498-2508. https://doi.org/10.1002/jps.24035

Cobalt-doped magnetite (CoxFe3 −xO4) nanoparticles have been produced through the microbial reduction of cobalt–iron oxyhydroxide by the bacterium Geobacter sulfurreducens. The materials produced, as measured by superconducting quantum interference d... Read More about Controlled Production of Poly (3-Hydroxybutyrate-co-3-Hydroxyhexanoate) (PHBHHx) Nanoparticles for Targeted and Sustained Drug Delivery.

The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months (2013)
Journal Article
Ali, K., Warusevitane, A., Lally, F., Sim, J., Sills, S., Pountain, S., …Roffe, C. (2013). The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months. PloS one, 8(6), Article e59274. https://doi.org/10.1371/journal.pone.0059274

INTRODUCTION: Post-stroke hypoxia is common, and may adversely affect outcome. We have recently shown that oxygen supplementation may improve early neurological recovery. Here, we report the six-month outcomes of this pilot study. METHODS: Patients w... Read More about The stroke oxygen pilot study: a randomized controlled trial of the effects of routine oxygen supplementation early after acute stroke--effect on key outcomes at six months.

Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering (2013)
Journal Article
Jenkins, S., Pickard, M., Furness, D., Yiu, H., & Chari, D. (2013). Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering. Nanomedicine, 951 -968. https://doi.org/10.2217/nnm.12.145

AIM: To analyze magnetic particle uptake and intracellular processing by the four main non-neuronal subclasses of the CNS: oligodendrocyte precursor cells; oligodendrocytes; astrocytes; and microglia. MATERIALS & METHODS: Magnetic particle uptake and... Read More about Differences in magnetic particle uptake by CNS neuroglial subclasses: implications for neural tissue engineering.

Editorial (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). Editorial. Clinical Biochemistry, 46(10-11), 840-841. https://doi.org/10.1016/j.clinbiochem.2013.05.060

After their discovery in mammalians, more than 20,000 publications about microRNAs have been recorded in Pubmed over the last 11 years. Although some aspects of their biology are still unknown and need some clarifications, it is now clear that microR... Read More about Editorial.

Prothymosin a overexpression contributes to the development of pulmonary emphysema (2013)
Journal Article
Wu. (2013). Prothymosin a overexpression contributes to the development of pulmonary emphysema. Nature communications, https://doi.org/10.1038/ncomms2906

Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin a transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin a in emphysema remains unclear. Here we show... Read More about Prothymosin a overexpression contributes to the development of pulmonary emphysema.

Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability (2013)
Journal Article
(2013). Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability. PloS one, e64862 -?. https://doi.org/10.1371/journal.pone.0064862

OBJECTIVES: To investigate whether normal variation of adult height is associated with clinical characteristics in rheumatoid arthritis (RA), including disease activity (DAS28), impairment of joint function (mechanical joint score, MJS) and overall d... Read More about Influence of adult height on rheumatoid arthritis: association with disease activity, impairment of joint function and overall disability.

Phase-resolved x-ray ferromagnetic resonance measurements of spin pumping in spin valve structures (2013)
Journal Article
Marcham, M. K., Shelford, L. R., Cavill, S. A., Keatley, P. S., Yu, W., Shafer, P., …Hicken, R. J. (2013). Phase-resolved x-ray ferromagnetic resonance measurements of spin pumping in spin valve structures. Physical review B: Condensed matter and materials physics, 87(18), https://doi.org/10.1103/physrevb.87.180403

Element-specific phase-resolved x-ray ferromagnetic resonance (FMR) was used to study spin pumping within Co 50 Fe 50 (3)/Cu(6)/Ni 80 Fe 20 (5) (thicknesses in nanometers) spin valve structures with large areas, so that edge effects typical o... Read More about Phase-resolved x-ray ferromagnetic resonance measurements of spin pumping in spin valve structures.

Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations (2013)
Journal Article
Judd, A. M., Scurr, D. J., Heylings, J. R., Wan, K., & Moss, G. P. (2013). Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations. Pharmaceutical Research, 30(7), 1896-1905. https://doi.org/10.1007/s11095-013-1032-5

Purpose In order to increase the efficacy of a topically applied antimicrobial compound the permeation profile, localisation and mechanism of action within the skin must first be investigated. Methods Time-of-flight secondary ion mass spectromet... Read More about Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations.

Calcitriol imparts neuroprotection to midbrain dopaminergic neurons through up-regulation of GDNF (2013)
Journal Article
Ormerod. (2013). Calcitriol imparts neuroprotection to midbrain dopaminergic neurons through up-regulation of GDNF. PloS one, e62040-?. https://doi.org/10.1371/journal.pone.0062040

During development a tightly controlled signaling cascade dictates the differentiation, maturation and survival of developing neurons. Understanding this signaling mechanism is important for developing therapies for neurodegenerative illnesses. In pr... Read More about Calcitriol imparts neuroprotection to midbrain dopaminergic neurons through up-regulation of GDNF.

Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression (2013)
Journal Article
(2013). Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression. PloS one, e62040 -?. https://doi.org/10.1371/journal.pone.0062040

During development a tightly controlled signaling cascade dictates the differentiation, maturation and survival of developing neurons. Understanding this signaling mechanism is important for developing therapies for neurodegenerative illnesses. In pr... Read More about Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression.

Remotely triggered scaffolds for controlled release of pharmaceuticals (2013)
Journal Article
(2013). Remotely triggered scaffolds for controlled release of pharmaceuticals. International Journal of Molecular Sciences, 8585 -8602. https://doi.org/10.3390/ijms14048585

Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery. Incorporation of the unique properties of HNPs into thermally responsive scaffolds holds great pot... Read More about Remotely triggered scaffolds for controlled release of pharmaceuticals.