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All Outputs (180)

Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology (2018)
Thesis
Ahmed, M. A. (2018). Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410299

Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tis... Read More about Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology.

Epigenomic changes associated with high-grade non-muscle invasive bladder cancer (2016)
Thesis
Kitchen, M. O. (2016). Epigenomic changes associated with high-grade non-muscle invasive bladder cancer. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/409152

The development and progression of high-grade non-muscle invasive bladder cancer (NMIBC) results from a complex interplay of environmental and heritable risk factors, including those that impact upon genetic and epigenetic pathways. Recent studies ha... Read More about Epigenomic changes associated with high-grade non-muscle invasive bladder cancer.

Interface modification in Co/Cu multilayers prepared by ion-assisted deposition (1998)
Thesis
Telling, N. Interface modification in Co/Cu multilayers prepared by ion-assisted deposition. (Thesis). Loughborough University. Retrieved from https://keele-repository.worktribe.com/output/828742

The interfacial structure of Co/Cu multilayers deposited under energetic ion bombardment has been investigated using X-ray reflectivity techniques. An ionassisted deposition system, based on unbalanced magnetron sputtering principles, has been develo... Read More about Interface modification in Co/Cu multilayers prepared by ion-assisted deposition.

Local and systemic endothelial injury in renal failure treated with peritoneal dialysis
Thesis
(2013). Local and systemic endothelial injury in renal failure treated with peritoneal dialysis

Excess fluid and waste products of metabolism, as well as protein, are removed from the peritoneal cavity in Peritoneal Dialysis (PD). Increased peritoneal protein clearance (Pcl) is associated with a greater risk of mortality. It is not clear whethe... Read More about Local and systemic endothelial injury in renal failure treated with peritoneal dialysis.

Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection
Thesis
(2013). Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection

Two major components of the common carp Cyprinus carpio innate response, i.e. the C-reactive protein (CRP) and the complement system, have been analysed in common carp either orally immunostimulated with ß-glucan or infected with a pathogen or both.... Read More about Immunomodulation of the innate response in common carp Cyprinus carpio by ß-glucan feeding and pathogenic infection.

Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations
Thesis
(2013). Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations

Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide. Identifying and avoiding disease progression risk factors is important in the management of CKD. Non-Steroidal Anti-inflammatory Drugs (NSAIDs), which are commonly pr... Read More about Influence of non-steroidal anti-inflammatory drugs on chronic kidney disease progression: an epidemiological study in general practice populations.

Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D
Thesis
(2012). Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D

In this thesis, recognition of the complex natural ligand lipopolysaccharide (LPS) by the innate immune proteins C-reactive protein (CRP) from Limulus polyphemus (Atlantic horseshoe crab), and human surfactant protein D, in the form of a recombinant... Read More about Structural studies of the interaction of bacterial lipopolysaccharides with C-reactive protein and lung surfactant protein D.

Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes
Thesis
(2012). Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes

Pathological conditions of cartilage resulting from acute injury are a major cause of morbidity. Surgical intervention, in most cases, does not repair cartilage to its native mechanical resilience. The potential benefits of non-invasive approaches fo... Read More about Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes.

The influence of the microenvironment on vascularisation of osteochondral tissues
Thesis
(2012). The influence of the microenvironment on vascularisation of osteochondral tissues

The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Articular cartilage is an avascular tissue and the presence of blood vessels is associated with various pathologies of the tissue. Conversely, bone requir... Read More about The influence of the microenvironment on vascularisation of osteochondral tissues.

Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis
Thesis
(2013). Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis

Aim: This thesis explores the complex cellular and biological interrelationships involved in Idiopathic Pulmonary Fibrosis (IPF) lung tissue remodelling using immunohistochemical analysis. Methods and results: 21 IPF and 19 control lung tissues were... Read More about Semi-quantitative immunohistochemical exploration of lung tissue remodelling in idiopathic pulmonary fibrosis.

The function of sodium/calcium ion exchanger in human platelets and megakaryocytes
Thesis
(2017). The function of sodium/calcium ion exchanger in human platelets and megakaryocytes

Previously work from our lab has predicted that Ca2+ release from intracellular Ca2+ stores occurs into a Na+/Ca2+ exchanger (NCX)-associated cytosolic nanodomain enclosed within the membrane complex. In this study, we aimed to test the hypothesis th... Read More about The function of sodium/calcium ion exchanger in human platelets and megakaryocytes.

Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes
Thesis
(2017). Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes

Recent study suggested that the anti-platelet effect of nicergoline is caused by inhibiting agonist-evoked Ca2+ signalling by disrupting the normal localization of the dense tubular system in human platelets. This effect is brought about by the disru... Read More about Investigating the effects of nicergoline on calcium signalling in human platelets and megakaryocytes.

An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells
Thesis
(2017). An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells

Type 1 diabetes is a challenging condition to manage effectively. Utilising the mesenchymal stem cell (MSC) secretome is an avenue being researched in regenerative medicine which could potentially ameliorate the condition. Previous studies have ident... Read More about An exploration of the effect of the mesenchymal stem cell secretome on pancreatic beta cells.

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. (2016). Optimising canine olfactory ensheathing cell therapy using tissue engineering tools

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. (2016). A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands

INTRODUCTION:
Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes.

AIM:
To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Hydrogen cyanide as an in-vitro and in-vivo marker of Pseudomonas aeruginosa infection
Thesis
(2014). Hydrogen cyanide as an in-vitro and in-vivo marker of Pseudomonas aeruginosa infection

The work presented in this thesis uses Selected Ion Flow Tube Mass Spectrometry to investigate if hydrogen cyanide (HCN) is a marker of Pseudomonas aeruginosa (PA). The initial in-vitro studies measure the HCN released into the gas phase by cultures... Read More about Hydrogen cyanide as an in-vitro and in-vivo marker of Pseudomonas aeruginosa infection.

Genetics of premenstrual syndrome: investigation of specific serotonin receptor polymorphisms
Thesis
(2014). Genetics of premenstrual syndrome: investigation of specific serotonin receptor polymorphisms

Premenstrual dysphoric disorder (PMDD) is a distressing and disabling syndrome causing a significant degree of impairment on daily functioning and interpersonal relationships in 3-8% of the women. With the convincing evidence that PMS is inheritable... Read More about Genetics of premenstrual syndrome: investigation of specific serotonin receptor polymorphisms.