All Outputs (108)

Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. (2013)
Presentation / Conference Contribution
Taccioli, C., Chen, H., Garofalo, M., Jiang, Y., Di Leva, G., Alder, H., Middleton, J., Smalley, K. J., Bottoni, A., Costinean, S., Farber, J. L., Croce, C. M., & Fong, L. Y. Y. Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats. Presented at AACR 104th Annual Meeting 2013; Apr 6-10, 2013, Washington, DC, USA

Dietary zinc deficiency (ZD) is implicated in the pathogenesis of human esophageal squamous cell carcinoma (ESCC). microRNA-31 (miR-31) is overexpressed in human ESCC. In the rat a ZD diet promotes esophageal carcinogenesis by inducing cellular proli... Read More about Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats..

The Effects of Laser Marking and Symbol Etching on the Fatigue Life of Medical Devices (2013)
Journal Article
Ogrodnik, P. J., Moorcroft, C. I., & Wardle, P. (2013). The Effects of Laser Marking and Symbol Etching on the Fatigue Life of Medical Devices. Journal of Medical Engineering, 2013, 1-6. https://doi.org/10.1155/2013/570354

This paper examines the question;“ does permanent laser marking affect the mechanical performance of a metallic medical component?” The literature review revealed the surprising fact that very little has been presented or studied even though intuitio... Read More about The Effects of Laser Marking and Symbol Etching on the Fatigue Life of Medical Devices.

Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis (2013)
Journal Article
Li, W., Gong, L., & Bayley, H. (2013). Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis. Angewandte Chemie International Edition, 52(16), 4350-4355. https://doi.org/10.1002/anie.201300413

DNA threading the needle: A new method of single-molecule detection of 5-hydroxymethylcytosine (5hmC) in DNA has been developed. Selective thiol substitution of 5hmC (giving SMC) in a single-step, bisulfite-mediated reaction (see scheme) allows the i... Read More about Single-Molecule Detection of 5-Hydroxymethylcytosine in DNA through Chemical Modification and Nanopore Analysis.

A switching multi-scale dynamical network model of EEG/MEG. (2013)
Journal Article
(2013). A switching multi-scale dynamical network model of EEG/MEG. NeuroImage, 262 - 287. https://doi.org/10.1016/j.neuroimage.2013.04.046

We introduce a new generative model of the Encephalography (EEG/MEG) data, the inversion of which allows for inferring the locations and temporal evolution of the underlying sources as well as their dynamical interactions. The proposed Switching Meso... Read More about A switching multi-scale dynamical network model of EEG/MEG..

Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke) (2013)
Journal Article
Chen, R. (2013). Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke). CNS and Neurological Disorders - Drug Targets, 12(2), 143-144. https://doi.org/10.2174/1871527311312020001

Stroke is a form of cardiovascular disease affecting blood supply to the brain. About 87% of strokes are ischemic, and the remainder are haemorrhagic. Ischaemic stroke is caused by the obstruction of blood flow in a brain artery leading to the lack o... Read More about Editorial (Current and Emerging Pharmacological Therapies of Ischaemic Stroke).

Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology (2013)
Journal Article
Maddock, K., & Richardson, A. (2013). Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology. Pharmacy Education, 36 - 39 (4)

Background: Pharmacy education requires an understanding of the fundamental principles of molecular pharmacology. Among these, abstract concepts such as affinity, association and dissociation rates and partial agonism may be difficult to demonstrate... Read More about Chairs, bells and students – a novel method to simulate and teach molecular interactions in pharmacology.

Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues (2013)
Journal Article
Hanifi, A., McCarthy, H., Roberts, S., & Pleshko, N. (2013). Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues. PloS one, 8(5), Article e64822. https://doi.org/10.1371/journal.pone.0064822

Hyaline cartilage and mechanically inferior fibrocartilage consisting of mixed collagen types are frequently found together in repairing articular cartilage. The present study seeks to develop methodology to identify collagen type and other tissue co... Read More about Fourier transform infrared imaging and infrared fiber optic probe spectroscopy identify collagen type in connective tissues.

Predicting intestinal absorption of raltegravir using a population-based ADME simulation (2013)
Journal Article
(2013). Predicting intestinal absorption of raltegravir using a population-based ADME simulation. Journal of Antimicrobial Chemotherapy, 1627-1634. https://doi.org/10.1093/jac/dkt084

Objectives
Raltegravir pharmacokinetics (PK) show high intra- and inter-patient variability and are also influenced by co-administered substances that alter the gastrointestinal tract environment, such as pH-altering or metal-containing agents. The... Read More about Predicting intestinal absorption of raltegravir using a population-based ADME simulation.

Oocyte-Secreted Factors in Domestic Animals (2013)
Book Chapter
Thompson, J. G., Mottershead, D. G., & Gilchrist, R. B. Oocyte-Secreted Factors in Domestic Animals. . Wiley. https://doi.org/10.1002/9781118538074.ch4

Summary
This chapter contains sections titled:
Introduction
Historical Background
Localization and Specificity
Structure and Genetic Diversity of Gdf9 and Bmp15
Signalling Mechanisms of Gdf9 and Bmp15
Roles of Oocyte-Secreted Factors
Manipula... Read More about Oocyte-Secreted Factors in Domestic Animals.

Stroke syndromes and clinical management (2013)
Journal Article
Balami, J. S., Chen, R. L., & Buchan, A. M. (2013). Stroke syndromes and clinical management. QJM: An International Journal of Medicine, 106(7), 607-615. https://doi.org/10.1093/qjmed/hct057

The knowledge of brain syndromes is essential for stroke physicians and neurologists, particularly those that can be extremely difficult and challenging to diagnose due to the great variability of symptom presentation and yet of clinical significance... Read More about Stroke syndromes and clinical management.

Effect of cotton padding on the setting properties of plaster slabs. (2013)
Journal Article
(2013). Effect of cotton padding on the setting properties of plaster slabs. Annals of The Royal College of Surgeons of England, 107 -109. https://doi.org/10.1308/003588413X13511609956291

INTRODUCTION: Plaster of Paris (PoP) impregnated bandages have been used to maintain the position of bones and joints for over a century. Classically, wool dressing is applied to the limb before the PoP, which can then be moulded to the desired shape... Read More about Effect of cotton padding on the setting properties of plaster slabs..

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. (2013)
Journal Article
Di Leva, G., Piovan, C., Gasparini, P., Ngankeu, A., Taccioli, C., Briskin, D., Cheung, D. G., Bolon, B., Anderlucci, L., Alder, H., Nuovo, G., Li, M., Iorio, M. V., Galasso, M., Ramasamy, S., Marcucci, G., Perrotti, D., Powell, K. A., Bratasz, A., Garofalo, M., …Croce, C. M. (2013). Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLOS genetics, 9(3), Article ARTN e1003311. https://doi.org/10.1371/journal.pgen.1003311

MicroRNAs (miRNAs), single-stranded non-coding RNAs, influence myriad biological processes that can contribute to cancer. Although tumor-suppressive and oncogenic functions have been characterized for some miRNAs, the majority of microRNAs have not b... Read More about Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status..

Cell Cultured Chondrocyte Implantation and Scaffold Techniques for Osteochondral Talar Lesions (2013)
Journal Article
Johnson, B., Lever, C., Roberts, S., Richardson, J., McCarthy, H., Harrison, P., Laing, P., & Makwana, N. (2013). Cell Cultured Chondrocyte Implantation and Scaffold Techniques for Osteochondral Talar Lesions. Foot and Ankle Clinics, 18(1), 135-150. https://doi.org/10.1016/j.fcl.2012.12.008

Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment (2013)
Journal Article
Balami, J. S., Fricker, R. A., & Chen, R. (2013). Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment. CNS & Neurological Disorders - Drug Targets, 12(2), 209 -219. https://doi.org/10.2174/1871527311312020007

No pharmacological intervention has been shown convincingly to improve neurological outcome in stroke patients after the brain tissue is infarcted. While conventional therapeutic strategies focus on preventing brain damage, stem cell treatment has th... Read More about Stem cell therapy for ischaemic stroke: translation from preclinical studies to clinical treatment.

miRNA profiling of cancer (2013)
Journal Article
Di Leva, G., & Croce, C. M. (2013). miRNA profiling of cancer. Current Opinion in Genetics and Development, 23(1), 3-11. https://doi.org/10.1016/j.gde.2013.01.004

A steadily growing number of studies have shown that microRNAs have key roles in the regulation of cellular processes and that their dysregulation is essential to keep the malignant phenotype of cancer cells. The distorted and unique expression profi... Read More about miRNA profiling of cancer.

Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface (2013)
Journal Article
Judd, A. M., Moss, G. P., Heylings, J., Wan, K.-W., & Yang, Y. (2013). Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface. Proceedings of SPIE, 8580, Article ARTN 85800G. https://doi.org/10.1117/12.2004754

Polyamidoamine (PAMAM) dendrimers have been topically applied to the skin and utilised as a permeation enhancer for a range of therapeutic compounds. However, very little is known about the mechanism of enhancement. This study used optical coherence... Read More about Optical Coherence Tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface.

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy (2013)
Journal Article
Papadakis, M., Hadley, G., Xilouri, M., Hoyte, L. C., Nagel, S., McMenamin, M. M., Tsaknakis, G., Watt, S. M., Drakesmith, C. W., Chen, R., Wood, M. J. A., Zhao, Z., Kessler, B., Vekrellis, K., & Buchan, A. M. (2013). Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nature Medicine, 19(3), 351-357. https://doi.org/10.1038/nm.3097

Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious therapies for acute ischemic stroke1. We hypothesized that studying the molecular determin... Read More about Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.

Influence of a Dy overlayer on the precessional dynamics of a ferromagnetic thin film (2013)
Journal Article
Marcham, M. K., Yu, W., Keatley, P. S., Shelford, L. R., Shafer, P., Cavill, S. A., Qing, H., Neudert, A., Childress, J. R., Katine, J. A., Arenholz, E., Telling, N. D., van der Laan, G., & Hicken, R. J. (2013). Influence of a Dy overlayer on the precessional dynamics of a ferromagnetic thin film. Applied Physics Letters, 102(6), 062418. https://doi.org/10.1063/1.4792740

Precessional dynamics of a Co50Fe50(0.7)/Ni90Fe10(5)/Dy(1)/Ru(3) (thicknesses in nm) thin film have been explored by low temperature time-resolved magneto-optical Kerr effect and phase-resolved x-ray ferromagnetic resonance measurements. As the tempe... Read More about Influence of a Dy overlayer on the precessional dynamics of a ferromagnetic thin film.

Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions (2013)
Journal Article
Richardson, A., Bracegirdle, L., McLachlan, S. I., & Chapman, S. R. (2013). Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions. American journal of pharmaceutical education, 77(1), 11. https://doi.org/10.5688/ajpe77111

Objective. To determine whether using 3-dimensional (3D) technology to teach pharmacy students about the molecular basis of the interactions between drugs and their targets is more effective than traditional lecture using 2-dimensional (2D) graphics.... Read More about Use of a Three-Dimensional Virtual Environment to Teach Drug-Receptor Interactions.

Preclinical evaluation of statins as a treatment for ovarian cancer (2013)
Journal Article
Robinson, E., Nandi, M., Wilkinson, L. L., Arrowsmith, D. M., Curtis, A. D., & Richardson, A. (2013). Preclinical evaluation of statins as a treatment for ovarian cancer. Gynecologic Oncology, 129(2), 417-424. https://doi.org/10.1016/j.ygyno.2013.02.003

Objective
To evaluate the potential for statins to treat ovarian cancer.

Methods
The sensitivity of 7 ovarian cancer cell lines to either statins or statins combined with either carboplatin or paclitaxel was assessed using monolayer cultures. Se... Read More about Preclinical evaluation of statins as a treatment for ovarian cancer.