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All Outputs (158)

Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells (2015)
Journal Article
Sharkey, D. J., Schjenken, J. E., Mottershead, D. G., & Robertson, S. A. (2015). Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells. Molecular and Cellular Endocrinology, 417(11), 178-190. https://doi.org/10.1016/j.mce.2015.09.022

Background: Overexpression of microRNA-31 (miR-31) is implicated in the pathogenesis of esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary zinc deficiency. Using a rat model that recapitulates features of human ESCC,... Read More about Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells.

Bivalirudin, glycoprotein inhibitor and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom (2015)
Journal Article
Mamas. (2015). Bivalirudin, glycoprotein inhibitor and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom. European Heart Journal, 1312-1320. https://doi.org/10.1093/eurheartj/ehv631

The HORIZONS trial reported a survival advantage for bivalirudin over heparin-with-glycoprotein inhibitors (GPIs) in primary PCI for ST elevation myocardial infarction. This drove an international shift in clinical practice. Subsequent studies have p... Read More about Bivalirudin, glycoprotein inhibitor and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom.

Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure (2015)
Journal Article
Nolan. (2015). Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure. Heart, 223 - 229. https://doi.org/10.1136/heartjnl-2015-308428

Objective We aimed to define the prognostic value of the heart rate range during a 24 h period in patients with chronic heart failure (CHF). Methods Prospective observational cohort study of 791 patients with CHF associated with left ventricular s... Read More about Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure.

Effect of age on the prognostic value of left ventricular function in patients with acute coronary syndrome: a prospective registry study (2015)
Journal Article
Mamas. (2015). Effect of age on the prognostic value of left ventricular function in patients with acute coronary syndrome: a prospective registry study. European Heart Journal: Acute Cardiovascular Care, 191-198. https://doi.org/10.1177/2048872615623038

Objective: This study aims to study the prognostic impact of LV function on mortality and examine the effect of age on the prognostic value of left ventricular function. Methods: We examined the Myocardial Ischaemia National Audit Project (MINAP) reg... Read More about Effect of age on the prognostic value of left ventricular function in patients with acute coronary syndrome: a prospective registry study.

In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors. (2015)
Journal Article
(2015). In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors. PloS one, e0145080 - ?. https://doi.org/10.1371/journal.pone.0145080

The current study has investigated the use of decellularised, demineralised bone extracellular matrix (ECM) hydrogel constructs for in vivo tissue mineralisation and bone formation. Stro-1-enriched human bone marrow stromal cells were incorporated to... Read More about In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors..

Primary care consultation rates among people with and without severe mental illness: a UK cohort study using the Clinical Practice Research Datalink. (2015)
Journal Article
(2015). Primary care consultation rates among people with and without severe mental illness: a UK cohort study using the Clinical Practice Research Datalink. BMJ Open, e008650 - ?. https://doi.org/10.1136/bmjopen-2015-008650

OBJECTIVES: Little is known about service utilisation by patients with severe mental illness (SMI) in UK primary care. We examined their consultation rate patterns and whether they were impacted by the introduction of the Quality and Outcomes Framewo... Read More about Primary care consultation rates among people with and without severe mental illness: a UK cohort study using the Clinical Practice Research Datalink..

Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK (2015)
Journal Article
(2015). Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK. BMJ Open, https://doi.org/10.1136/bmjopen-2015-009010

Objectives Little is known about the prevalence of comorbidity rates in people with severe mental illness (SMI) in UK primary care. We calculated the prevalence of SMI by UK country, English region and deprivation quintile, antipsychotic and antidepr... Read More about Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK.

A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy (2015)
Journal Article
Stewart. (2015). A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy. AJP - Endocrinology and Metabolism, E1019 - E1031. https://doi.org/10.1152/ajpendo.00375.2015

Skeletal muscle is a direct target for vitamin D. Observational studies suggest that low 25[OH]D correlates with functional recovery of skeletal muscle following eccentric contractions in humans and crush injury in rats. However, a definitive associa... Read More about A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy.

Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty (2015)
Journal Article
Khan, M., Kuiper, J., Sieniawska, C., & Richardson, J. (2016). Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty. Journal of Orthopaedics, 13(4), 450-454. https://doi.org/10.1016/j.jor.2015.10.006

Background/aims Cobalt and chromium are released from MOM hips and their precise nature (ions/particles) is not known. Their distribution in serum, plasma, and whole blood may help to determine their nature. Methods We measured cobalt and chromi... Read More about Differences in concentration of metal debris in blood, serum, and plasma samples of patients with metal-on-metal hip resurfacing arthroplasty.

The Concise Guide to PHARMACOLOGY 2015/16: Overview: The Concise Guide to PHARMACOLOGY 2015/16: Overview (2015)
Journal Article
Alexander, S. P., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., …Wong, S. S. (2015). The Concise Guide to PHARMACOLOGY 2015/16: Overview: The Concise Guide to PHARMACOLOGY 2015/16: Overview. British Journal of Pharmacology, 172(24), 5729-5743. https://doi.org/10.1111/bph.13347

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.... Read More about The Concise Guide to PHARMACOLOGY 2015/16: Overview: The Concise Guide to PHARMACOLOGY 2015/16: Overview.

Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review (2015)
Journal Article
Yang, Y. (2015). Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review. Journal of Neurorestoratology, 123 - 131. https://doi.org/10.2147/JN.S70337

Restoration of function following damage to the central nervous system (CNS) is severely restricted by several factors. These include the hindrance of axonal regeneration imposed by glial scars resulting from inflammatory response to damage, and limi... Read More about Nanofibrous scaffolds supporting optimal central nervous system regeneration: an evidence-based review.

Heart failure and chronic obstructive pulmonary disease multimorbidity at hospital discharge transition: a study of patient and carer experience (2015)
Journal Article
Davies. (2015). Heart failure and chronic obstructive pulmonary disease multimorbidity at hospital discharge transition: a study of patient and carer experience. Health Expectations, 2401 -2412. https://doi.org/10.1111/hex.12208

BACKGROUND: Care for patients with multimorbidity represents a major challenge not only for patients and carers but to health-care systems. Hospital discharge transition is a critical point at which challenges for multimorbidity may amplify. OBJECTIV... Read More about Heart failure and chronic obstructive pulmonary disease multimorbidity at hospital discharge transition: a study of patient and carer experience.

A detailed quantitative outcome measure of glycosaminoglycans in human articular cartilage for cell therapy and tissue engineering strategies (2015)
Journal Article
(2015). A detailed quantitative outcome measure of glycosaminoglycans in human articular cartilage for cell therapy and tissue engineering strategies. Osteoarthritis and Cartilage, 2233-2241. https://doi.org/10.1016/j.joca.2015.07.011

Objective Ideally, cartilage regenerative cell therapy should produce a tissue which closely matches the microstructure of native cartilage. Benchmark reference information is necessary to assess the quality of engineered cartilage. Our goal was to... Read More about A detailed quantitative outcome measure of glycosaminoglycans in human articular cartilage for cell therapy and tissue engineering strategies.

Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes (2015)
Journal Article
Gilchrist, F. (2015). Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes. Practical Diabetes, 333-335a. https://doi.org/10.1002/pdi.1984

The UK Cystic Fibrosis (CF) Trust guidelines state that the diagnosis of CF related diabetes (CFRD) should only be made after an oral glucose tolerance test in the diabetic range and hyperglycaemia on serial monitoring. We report three patients with... Read More about Diabetic retinopathy in patients who do not meet the diagnostic criteria for cystic fibrosis related diabetes.

Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study (2015)
Journal Article
Venables. (2015). Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study. International Journal of Pharmaceutics, 12 - 17. https://doi.org/10.1016/j.ijpharm.2015.11.010

There is a paucity of research exploring barriers to non-oral medicines administration in paediatric patients; however, these undoubtedly influence medicines adherence. Studies conducted with healthcare professionals have identified various issues wi... Read More about Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study.

Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers (2015)
Journal Article
Kumar, D., Dale, T. P., Yang, Y., & Forsyth, N. R. (2015). Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers. Biomedical Materials, 10(6), Article 065017. https://doi.org/10.1088/1748-6041/10/6/065017

Human embryonic stem cells (hESCs) are conventionally expanded and maintained in vitro on biological substrates. Synthetic electrospun polymer nanofibers have the potential to act as non-biological substrates in the culture of hESCs. Three synthetic,... Read More about Self-renewal of human embryonic stem cells on defined synthetic electrospun nanofibers.

Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis (2015)
Journal Article
Mamas. (2015). Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis. Diabetes Care, 2354-2369. https://doi.org/10.2337/dc15-1188

OBJECTIVE Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular... Read More about Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis.

Selected Ion Flow-Drift Tube Mass Spectrometry: Quantification of Volatile Compounds in Air and Breath (2015)
Journal Article
(2015). Selected Ion Flow-Drift Tube Mass Spectrometry: Quantification of Volatile Compounds in Air and Breath. Analytical Chemistry, 12151 -12160. https://doi.org/10.1021/acs.analchem.5b02994

A selected ion flow-drift tube mass spectrometric analytical technique, SIFDT-MS, is described that extends the established selected ion flow tube mass spectrometry, SIFT-MS, by the inclusion of a static but variable E-field along the axis of the flo... Read More about Selected Ion Flow-Drift Tube Mass Spectrometry: Quantification of Volatile Compounds in Air and Breath.