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All Outputs (244)

Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment (2016)
Conference Proceeding
El Haj, A. J., Reinwald, Y., Baganinchi, P., Gamal, W., & Yang, Y. (2016). Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment.

Introduction: Monitoring the maturation of engineered tissues prior to implantation into the patient is important for defining quality and manufacturing criteria. Key properties include scaffold integrity and mechanical properties. Novel non-invasive... Read More about Online Monitoring Of Mechanical Properties Of 3D Tissue Engineered Constructs For Quality Assessment.

Toxicological and Analytical Assessment of E-Cigarette Refill Components on Airway Epithelia (2016)
Journal Article
Singh, J., Luquet, E., Smith, D. P., Potgieter, H. J., & Ragazzon, P. (2016). Toxicological and Analytical Assessment of E-Cigarette Refill Components on Airway Epithelia. Science Progress, 99(4), 351-398. https://doi.org/10.3184/003685016x14773090197706

There are over 2.6 million users of e-cigarettes in the United Kingdom alone as they have been promoted as a safer alternative to traditional cigarettes. The addition of flavours and aromas has also proven to be popular with younger generations. In t... Read More about Toxicological and Analytical Assessment of E-Cigarette Refill Components on Airway Epithelia.

Analysis of cartilage oligomeric matrix protein in synovial fluid, plasma and repair tissue of patients treated with autologous chondrocyte implantation (2016)
Journal Article
McCarthy, H., Wright, K., Williams, J., Gallacher, P., Richardson, J., & Roberts, S. (2016). Analysis of cartilage oligomeric matrix protein in synovial fluid, plasma and repair tissue of patients treated with autologous chondrocyte implantation. International Journal of Experimental Pathology, A11 -A12. https://doi.org/10.1111/iep.12211

Meeting abstract.

Hawks, Doves and Rasch decisions: Understanding the influence of different cycles of an OSCE on students' scores using Many Facet Rasch Modeling (2016)
Journal Article
Yeates. (2016). Hawks, Doves and Rasch decisions: Understanding the influence of different cycles of an OSCE on students' scores using Many Facet Rasch Modeling. Medical Teacher, 92-99. https://doi.org/10.1080/0142159x.2017.1248916

INTRODUCTION: OSCEs are commonly conducted in multiple cycles (different circuits, times, and locations), yet the potential for students' allocation to different OSCE cycles is rarely considered as a source of variance-perhaps in part because convent... Read More about Hawks, Doves and Rasch decisions: Understanding the influence of different cycles of an OSCE on students' scores using Many Facet Rasch Modeling.

3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells (2016)
Journal Article
Eurtivong, C., Semenov, V., Semenova, M., Konyushkin, L., Atamanenko, O., Reynisson, J., & Kiselyov, A. (2017). 3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells. Bioorganic and Medicinal Chemistry, 25(2), 658-664. https://doi.org/10.1016/j.bmc.2016.11.041

A series of 3-amino-thieno[2,3-b]pyridines was prepared and tested in a phenotypic sea urchin embryo assay to identify potent and specific molecules that affect tubulin dynamics. The most active compounds featured a tricyclic core ring system with a... Read More about 3-Amino-thieno[2,3-b]pyridines as microtubule-destabilising agents: Molecular modelling and biological evaluation in the sea urchin embryo and human cancer cells.

Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia (2016)
Journal Article
Mladinov, M., Sedmak, G., Fuller, H., Babić Leko, M., Mayer, D., Kirincich, J., …Šimić, G. (2016). Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia. Translational Neuroscience, https://doi.org/10.1515/tnsci-2016-0021

Schizophrenia is a complex polygenic disorder of unknown etiology. Over 3,000 candidate genes associated with schizophrenia have been reported, most of which being mentioned only once. Alterations in cognitive processing - working memory, metacogniti... Read More about Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia.

Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study (2016)
Journal Article
Roffe. (2016). Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study. https://doi.org/10.1016/j.phmed.2016.11.001

Acute Ischemic Stroke (AIS) is the major type of stroke occurring in patients. Aspiration thrombectomy, which uses suction to remove the thrombosis, is a promising technique in the clinical treatment of AIS patients. In this research a computational... Read More about Suction force-suction distance relation during aspiration thrombectomy for ischemic stroke: A computational fluid dynamics study.

Real-time simulation of hand motion for prosthesis control (2016)
Journal Article
(2016). Real-time simulation of hand motion for prosthesis control. Computer Methods in Biomechanics and Biomedical Engineering, 540-549. https://doi.org/10.1080/10255842.2016.1255943

Individuals with hand amputation suffer substantial loss of independence. Performance of sophisticated prostheses is limited by the ability to control them. To achieve natural and simultaneous control of all wrist and hand motions, we propose to use... Read More about Real-time simulation of hand motion for prosthesis control.

Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry (2016)
Journal Article
Mamas, M. A., Shing Kwok, C., Kontopantelis, E., Fryer, A. A., Buchan, I., Bachmann, M. O., …Myint, P. K. (2016). Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry. Journal of the American Heart Association, 5(11), https://doi.org/10.1161/JAHA.116.003348

BACKGROUND: We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. METHODS AND... Read More about Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry.

Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry (2016)
Journal Article
Mamas. (2016). Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, https://doi.org/10.1161/JAHA.116.003348

Background
We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort.

Methods... Read More about Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry.

Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation (2016)
Journal Article
(2016). Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology, 109 - 129. https://doi.org/10.1007/s10522-016-9667-3

Sarcopenic obesity is characterised by high fat mass, low muscle mass and an elevated inflammatory environmental milieu. We therefore investigated the effects of elevated inflammatory cytokine TNF-a (aging/obesity) and saturated fatty acid, palmitate... Read More about Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation.

Review of early hospitalization after percutaneous coronary intervention (2016)
Journal Article
Mamas. (2016). Review of early hospitalization after percutaneous coronary intervention. International Journal of Cardiology, 370-377. https://doi.org/10.1016/j.ijcard.2016.11.050

Background
Percutaneous coronary intervention (PCI) is the most common modality of revascularization in patients with coronary artery disease. Understanding the readmission rates and reasons for readmission after PCI is important because readmission... Read More about Review of early hospitalization after percutaneous coronary intervention.

Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis (2016)
Journal Article
Davies, & Mamas. (2016). Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis. International Journal of Cardiology, 122-128. https://doi.org/10.1016/j.ijcard.2016.11.136

Background
Ultrafiltration is a method used to achieve diuresis in acute decompensated heart failure (ADHF) when there is diuretic resistance, but its efficacy in other settings is unclear. We therefore conducted a systematic review and meta-analysi... Read More about Ultrafiltration for acute decompensated cardiac failure: A systematic review and meta-analysis.

Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation (2016)
Journal Article
Mamas. (2016). Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation. American Heart Journal, 97-105. https://doi.org/10.1016/j.ahj.2016.10.020

Background
The performance of emerging transcatheter aortic valve implantation (TAVI) clinical prediction models (CPMs) in national TAVI cohorts distinct from those where they have been derived is unknown. This study aimed to investigate the perform... Read More about Inadequacy of Existing Clinical Prediction Models for Predicting Mortality after Transcatheter Aortic Valve Implantation.

Postexercise High-Fat Feeding Suppresses p70S6K1 Activity in Human Skeletal Muscle (2016)
Journal Article
(2016). Postexercise High-Fat Feeding Suppresses p70S6K1 Activity in Human Skeletal Muscle. Medicine and Science in Sports and Exercise, 2108 - 2117. https://doi.org/10.1249/MSS.0000000000001009

Purpose This study aimed to examine the effects of reduced CHO but high postexercise fat availability on cell signaling and expression of genes with putative roles in regulation of mitochondrial biogenesis, lipid metabolism, and muscle protein synthe... Read More about Postexercise High-Fat Feeding Suppresses p70S6K1 Activity in Human Skeletal Muscle.

Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation (2016)
Journal Article
(2016). Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/AAC.01841-16

Adequate concentrations of efavirenz in the central nervous system (CNS) are necessary to suppress viral replication, but high concentrations may increase the likelihood of CNS adverse drug reactions. The aim of this investigation was to evaluate the... Read More about Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation.