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All Outputs (188)

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT. (2019)
Journal Article
Roffe. (2019). Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT. Health Technology Assessment, 1 - 48. https://doi.org/10.3310/hta23350

BACKGROUND:Tranexamic acid reduces death due to bleeding after trauma and postpartum haemorrhage. OBJECTIVE:The aim of the study was to assess if tranexamic acid is safe, reduces haematoma expansion and improves outcomes in adults with spontaneous in... Read More about Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT..

Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations. (2019)
Journal Article
Farooq, S., Chew-Graham, C., Mamas, M., & Rashid, M. (2019). Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations. Canadian Journal of Cardiology, 821-830. https://doi.org/10.1016/j.cjca.2019.04.021

Patients with severe mental illness (SMI) are a high-risk group for cardiovascular disease. The present study examined the prevalence and outcomes of SMI patients in a national AMI cohort. SMI has doubled in prevalence amongst AMI patients, mainly du... Read More about Acute Myocardial Infarction in Severe Mental Illness: prevalence, clinical outcomes and process of care in United States hospitalizations..

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5 (2019)
Journal Article
Reynisson. (2019). Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5. Molecules, https://doi.org/10.3390/molecules24132415

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. In these Edito... Read More about Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs) (2019)
Thesis
Sykes, J. G. (2019). Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs). (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414327

Autologous chondrocyte implantation (ACI) is the only UK approved cell therapy or knee cartilage defects which might otherwise progress to osteoarthritis. For ACI, chondrocytes isolated from a healthy cartilage biopsy are expanded in number prior to... Read More about Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs).

Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study (2019)
Thesis
Cork, T. A. (2019). Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414218

Background – Research has consistently shown that approximately 50% of patients do not take their prescribed medication correctly. A commonly overlooked factor in patient’s lack of understanding of health information and medicine instructions is limi... Read More about Identifying health literacy interventions for everyday use in community pharmacy: a qualitative and consensus methodology study.

Engineering and optimising a functional in vitro model of basal ganglia circuitry (2019)
Thesis
Kӧse-Dunn, M. J. (2019). Engineering and optimising a functional in vitro model of basal ganglia circuitry. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413812

The majority of neurological diseases (such as Parkinson’s and Huntington’s diseases) are progressive, debilitating and currently incurable. In an ageing population, the prevalence of such diseases will only increase over time, creating a need for be... Read More about Engineering and optimising a functional in vitro model of basal ganglia circuitry.

Characterising microglial activation: refinement and validation of primary in vitro models (2019)
Thesis
Al-Shaheeb, S. (2019). Characterising microglial activation: refinement and validation of primary in vitro models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413772

Background: Neuroinflammation is common to many neurodegenerative conditions and is principally mediated by microglia. Microglia maintain homeostasis, respond to trauma/infection and can promote repair. This is achieved by switching between surveilla... Read More about Characterising microglial activation: refinement and validation of primary in vitro models.

Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells (2019)
Thesis
Ibrahim, . S. L. (2019). Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413776

Breast cancer is considered the most frequently diagnosed cancer in women and the second most common type of cancer causing deaths among women. It is accounts 25% of all female cancers. It is expected about 1 in 8 women will develop this disease duri... Read More about Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells.

Teaching decision-making and professional ethics for pharmacy practice: a mixed methods study (2019)
Thesis
Allinson, M. D. (2019). Teaching decision-making and professional ethics for pharmacy practice: a mixed methods study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413777

Little has been published on whether or not ethics teaching during undergraduate study effectively prepares pharmacy students for dealing with dilemmas in future practice. The aim of this study was to explore the user’s perspectives on the effectiven... Read More about Teaching decision-making and professional ethics for pharmacy practice: a mixed methods study.

Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders (2019)
Thesis
Hmeidi, H. (2019). Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413771

Current Lung function assessments in children can be clinically challenging and even inapplicable in preschool children, this is due to the test requirements of cooperation and understanding. Hence, there is a need for new techniques that can overcom... Read More about Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders.

Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration (2019)
Thesis
Younus, Z. M. (2019). Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413770

Osteochondral defects are serious clinical problems relating to damaged articular cartilage within joints, usually resulting from acute traumatic injury or an underlying bone disorder. A variety of therapeutic options have been investigated, with sev... Read More about Design and fabrication of hydrogel scaffolds for osteochondral tissue regeneration.

long term follow-up of FoRT: a phase 3 multi-center prospective randomized trial of radiation therapy for follicular and marginal zone lymphoma (2019)
Journal Article
Hoskin, P., Kirkwood, A., Popova, B., Schofield, O., Brammer, C., Robinson, M., …Clifton-Hadley, L. (2019). long term follow-up of FoRT: a phase 3 multi-center prospective randomized trial of radiation therapy for follicular and marginal zone lymphoma. Hematological Oncology, 37(S2), 219 - 220. https://doi.org/10.1002/hon.34_2630

Supplement article.

Less is more: Investigating the influence of cellular nanoparticle load on transfection outcomes in neural cells (2019)
Journal Article
Chari, D. M., & Tickle, J. A. (2019). Less is more: Investigating the influence of cellular nanoparticle load on transfection outcomes in neural cells. Journal of Tissue Engineering and Regenerative Medicine, https://doi.org/10.1002/term.2909

Genetic engineering of cell transplant populations offers potential for delivery of neurotherapeutic factors to modify the regenerative microenvironment of the injured spinal cord. The use of magnetic nanoparticle (MNP) based vectors has reduced the... Read More about Less is more: Investigating the influence of cellular nanoparticle load on transfection outcomes in neural cells.

Low pre-exercise muscle glycogen availability offsets the effect of post exercise cold water immersion in augmenting PGC-1a gene expression (2019)
Journal Article
(2019). Low pre-exercise muscle glycogen availability offsets the effect of post exercise cold water immersion in augmenting PGC-1a gene expression. Physiological Reports, e14082. https://doi.org/10.14814/phy2.14082

We assessed the effects of post-exercise cold-water immersion (CWI) in modulating PGC-1a mRNA expression in response to exercise commenced with low muscle glycogen availability. In a randomized repeated-measures design, nine recreationally active mal... Read More about Low pre-exercise muscle glycogen availability offsets the effect of post exercise cold water immersion in augmenting PGC-1a gene expression.

A micro-fabricated in vitro complex neuronal circuit platform (2019)
Journal Article
(2019). A micro-fabricated in vitro complex neuronal circuit platform. Biomedical Physics & Engineering Express, 045016 - 045016. https://doi.org/10.1088/2057-1976/ab2307

Developments in micro-manufacture as well as biofabrication technologies are driving our ability to create complex tissue models such as 'organ-on-a-chip' devices. The complexity of neural tissue, however, requires precisely specific cellular connect... Read More about A micro-fabricated in vitro complex neuronal circuit platform.

A Micro-fabricated in vitro Platform to Model Complex Neuronal Functionality of a Central Nervous System Circuit (2019)
Journal Article
(2019). A Micro-fabricated in vitro Platform to Model Complex Neuronal Functionality of a Central Nervous System Circuit. Biomedical Physics & Engineering Express, https://doi.org/10.1088/2057-1976/ab2307

Developments in micro-manufacture as well as biofabrication technologies are driving our ability to create complex tissue models such as‘organ-on-a-chip’ devices. The complexity of neural tissue, however, requires precisely specific cellular connecti... Read More about A Micro-fabricated in vitro Platform to Model Complex Neuronal Functionality of a Central Nervous System Circuit.

Predictors of fracture healing in patients with recalcitrant nonunions treated with autologous culture expanded bone marrow-derived mesenchymal stromal cells. (2019)
Journal Article
Kuiper. (2019). Predictors of fracture healing in patients with recalcitrant nonunions treated with autologous culture expanded bone marrow-derived mesenchymal stromal cells. Journal of Orthopaedic Research, 1303-1309. https://doi.org/10.1002/jor.24184

The study reports the prospective outcome of treating severe recalcitrant fracture nonunion in patients with autologous bone marrow-derived mesenchymal stromal cells (BMSC) from 2003 to 2010 and analyze predictors of union. Autologous BMSC were cultu... Read More about Predictors of fracture healing in patients with recalcitrant nonunions treated with autologous culture expanded bone marrow-derived mesenchymal stromal cells..

Development of New Antithrombotic Regimens for Patients with Acute Coronary Syndrome. (2019)
Journal Article
(2019). Development of New Antithrombotic Regimens for Patients with Acute Coronary Syndrome. Clinical Drug Investigation, 495-502. https://doi.org/10.1007/s40261-019-00769-6

Patients with acute coronary syndrome (ACS) require long-term antithrombotic intervention to reduce the risk of further ischemic events; dual antiplatelet therapy with a P2Y12 inhibitor and acetylsalicylic acid (ASA) is the current standard of care.... Read More about Development of New Antithrombotic Regimens for Patients with Acute Coronary Syndrome..