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Safety and efficacy of umbilical cord-derived Wharton's jelly compared to hyaluronic acid and saline for knee osteoarthritis: study protocol for a randomized, controlled, single-blind, multi-center trial. (2021)
Journal Article
(2021). Safety and efficacy of umbilical cord-derived Wharton's jelly compared to hyaluronic acid and saline for knee osteoarthritis: study protocol for a randomized, controlled, single-blind, multi-center trial. Journal of Orthopaedic Surgery and Research, -. https://doi.org/10.1186/s13018-021-02497-0

BACKGROUND: Osteoarthritis (OA) is the most common joint disorder in the United States of America (USA) with a fast-rising prevalence. Current treatment modalities are limited, and total knee replacement surgeries have shown disadvantages, especially... Read More about Safety and efficacy of umbilical cord-derived Wharton's jelly compared to hyaluronic acid and saline for knee osteoarthritis: study protocol for a randomized, controlled, single-blind, multi-center trial..

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments. (2021)
Journal Article
Reynisson. (2021). Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments. Molecules, 1-23. https://doi.org/10.3390/molecules26113128

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monot... Read More about Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments..

Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study (2021)
Journal Article
Roffe. (2021). Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study. Diagnostic and Prognostic Research, https://doi.org/10.1186/s41512-021-00098-3

Abstract Background Rapid treatment of stroke improves outcomes, but accurate early recognition can be challenging. Between 20 and 40% of patients suspected to have stroke by ambulance and emergency department staff later receive a non-stroke ‘mimic’... Read More about Purines for Rapid Identification of Stroke Mimics (PRISM): study protocol for a diagnostic accuracy study.

Scalable electrochemical synthesis of diaryliodonium salts (2021)
Journal Article
Elsherbini, M., & Moran, W. J. (2021). Scalable electrochemical synthesis of diaryliodonium salts. Organic and Biomolecular Chemistry, 19(21), 4706-4711. https://doi.org/10.1039/d1ob00457c

Cyclic and acyclic diaryliodonium are synthesised by anodic oxidation of iodobiaryls and iodoarene/arene mixtures, respectively, in a simple undivided electrolysis cell in MeCN–HFIP–TfOH without any added electrolyte salts. This atom efficient proces... Read More about Scalable electrochemical synthesis of diaryliodonium salts.

Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review (2021)
Journal Article
Migliorini, F., Maffulli, N., Baroncini, A., Knobe, M., Tingart, M., & Eschweiler, J. (2021). Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review. British Medical Bulletin, 138(1), 144-154. https://doi.org/10.1093/bmb/ldab008

AbstractIntroductionChondral defects of the talus are common and their treatment is challenging.Source of dataRecent published literatures.Areas of agreementMembrane-induced Autologous Chondrocyte Implantation (mACI) and Autologous Matrix-Induced Cho... Read More about Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review.

Improving the solubility of anti-proliferative thieno[2,3-b]quinoline-2-carboxamides. (2021)
Journal Article
Reynisson. (2021). Improving the solubility of anti-proliferative thieno[2,3-b]quinoline-2-carboxamides. Bioorganic and Medicinal Chemistry, 1- 10. https://doi.org/10.1016/j.bmc.2021.116092

Thieno[2,3-b]pyridines are a class of compounds known for their potent anti-proliferative activities against a range of human cancer cell lines. In this research, a number of strategies to generate analogues that have improved aqueous solubility whil... Read More about Improving the solubility of anti-proliferative thieno[2,3-b]quinoline-2-carboxamides..

Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy (2021)
Journal Article
Hulme, & Wright Bevans. (2021). Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. American Journal of Sports Medicine, 1512-1523

Background: Biomarkers are needed to predict clinical outcome for microfracture and osteotomy surgeries to ensure patients can be better stratified to receive the most appropriate treatment. Hypothesis/purpose: To identify novel biomarker candidate... Read More about Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy.

DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells (2021)
Journal Article
Kitchen. (2021). DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells. Cells, 1032 - 1032. https://doi.org/10.3390/cells10051032

The application of physiological oxygen (physoxia) concentrations is becoming increasingly commonplace within a mammalian stem cell culture. Human mesenchymal stem cells (hMSCs) attract widespread interest for clinical application due to their unique... Read More about DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.

The Management of Talar Osteochondral Lesions - Current Concepts (2021)
Journal Article
Lan, T., McCarthy, H., Hulme, C., Wright, K., & Makwana, N. (2021). The Management of Talar Osteochondral Lesions - Current Concepts. Journal of Arthroscopy and Joint Surgery, 231-237. https://doi.org/10.1016/j.jajs.2021.04.002

Osteochondral lesions of the talus (OLTs) are a common complication following trauma, involving both the articular cartilage and the underlying subchondral bone, with variable aetiologies and often presenting with non-specific symptoms. Diagnosis of... Read More about The Management of Talar Osteochondral Lesions - Current Concepts.

Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke (2021)
Journal Article
Patabendige, A., Singh, A., Jenkins, S., Sen, J., & Chen, R. (2021). Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke. International Journal of Molecular Sciences, 22(8), https://doi.org/10.3390/ijms22084280

Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and cognitive deficits. Despite promising pre-clinical studies, clinically appr... Read More about Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke.

Comparable outcome for autografts and allografts in primary medial patellofemoral ligament reconstruction for patellofemoral instability: systematic review and meta-analysis (2021)
Journal Article
Migliorini, F., Trivellas, A., Eschweiler, J., Knobe, M., Tingart, M., & Maffulli, N. (2022). Comparable outcome for autografts and allografts in primary medial patellofemoral ligament reconstruction for patellofemoral instability: systematic review and meta-analysis. Knee Surgery, Sports Traumatology, Arthroscopy, 30(4), 1282-1291. https://doi.org/10.1007/s00167-021-06569-w

PURPOSE: This study updates the current evidence on the role of allografts versus autografts for medial patellofemoral ligament (MPFL) reconstruction in patients with patellofemoral instability. METHODS: The study was performed according to the PRISM... Read More about Comparable outcome for autografts and allografts in primary medial patellofemoral ligament reconstruction for patellofemoral instability: systematic review and meta-analysis.

Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results (2021)
Journal Article
Michaelidou, M., Yadegarfar, G., Morris, L., Dolan, S., Robinson, A., Naseem, A., …Heald, A. H. (2021). Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results. Cardiovascular Endocrinology & Metabolism, 10(2), 137 - 145. https://doi.org/10.1097/XCE.0000000000000250

Background The short synacthen test (SST) is the most commonly performed investigation to assess adrenal function. Appropriate criteria for when an SST is performed are subject to debate. We investigated how random serum cortisol levels relate to SST... Read More about Recalibration of thinking about adrenocortical function assessment: how the 'random' cortisol relates to the short synacthen test results.

Isolated medial patellofemoral ligament reconstruction for recurrent patellofemoral instability: analysis of outcomes and risk factors. (2021)
Journal Article
(2021). Isolated medial patellofemoral ligament reconstruction for recurrent patellofemoral instability: analysis of outcomes and risk factors. Journal of Orthopaedic Surgery and Research, 239 - ?. https://doi.org/10.1186/s13018-021-02383-9

BACKGROUND: The medial patellofemoral ligament (MPFL) is always damaged after patellar dislocation. In selected patients, MPFL reconstruction is necessary to restore a correct patellar tracking. Despite the large number of different techniques report... Read More about Isolated medial patellofemoral ligament reconstruction for recurrent patellofemoral instability: analysis of outcomes and risk factors..

Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications (2021)
Journal Article
Zare, M., Davoodi, P., & Ramakrishna, S. (2021). Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications. Nanomaterials, 11(4), 1 - 25. https://doi.org/10.3390/nano11040933

Shape memory polymers (SMPs) as a relatively new class of smart materials have gained increasing attention in academic research and industrial developments (e.g., biomedical engineering, aerospace, robotics, automotive industries, and smart textiles)... Read More about Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications.

Pharmacy graduates' perceived impact of long-term undergraduate use of an ethical decision-support tool on their early practice. (2021)
Journal Article
White, S., Allinson, M., & Black, P. (2021). Pharmacy graduates' perceived impact of long-term undergraduate use of an ethical decision-support tool on their early practice. Currents in Pharmacy Teaching and Learning, 13(7), 760 - 769. https://doi.org/10.1016/j.cptl.2021.03.001

INTRODUCTION: Values-based practice is an important concept within healthcare decision-making that sits alongside evidence-based practice. Values Exchange (Vx) (http://www.vxcommunity.com) is an online tool that supports the development of ethical an... Read More about Pharmacy graduates' perceived impact of long-term undergraduate use of an ethical decision-support tool on their early practice..

Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation (2021)
Journal Article
Curtis, A., Alsuraifi, A., Mathew, E., Lamprou, D. A., & Hoskins, C. (2021). Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation. International Journal of Pharmaceutics, 601, Article ARTN 120570. https://doi.org/10.1016/j.ijpharm.2021.120570

Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles. Polymers of N-(3-aminopropyl) methacrylamide hydrochloride (APMA) are cationic with primary amine groups in their... Read More about Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation.

A KRAS-responsive long non-coding RNA controls microRNA processing (2021)
Journal Article
Shi, L., Magee, P., Fassan, M., Sahoo, S., Leong, H. S., Lee, D., …Garofalo, M. (2021). A KRAS-responsive long non-coding RNA controls microRNA processing. Nature communications, 12, Article 2038. https://doi.org/10.1038/s41467-021-22337-3

Wild-type KRAS (KRASWT) amplification has been shown to be a secondary means of KRAS activation in cancer and associated with poor survival. Nevertheless, the precise role of KRASWT overexpression in lung cancer progression is largely unexplored. Her... Read More about A KRAS-responsive long non-coding RNA controls microRNA processing.

Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee (2021)
Thesis
Hopkins, T. (2021). Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee. (Thesis). Keele University

Damage to the articular cartilage (AC) in the human knee, caused by physical trauma or degenerative disease, represents a common and complex clinical problem. AC has a very limited capacity for self-repair and, once damaged, rarely heals spontaneousl... Read More about Investigating the impact of subchondral bone health and activity levels on cartilage repair in the knee.

Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models (2021)
Thesis
Green, E. L. (2021). Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models. (Thesis). Keele University

Parkinson’s disease (PD) is characterised by motor symptoms caused by degeneration of dopaminergic neurons in the substantia nigra. The cause remains elusive and current treatments cannot halt or reverse progression. This thesis explores the effects... Read More about Nicotinamide, neural cells, and Parkinson’s disease: exploring nicotinamide’s effects on proliferation, neuronal differentiation, and neuroprotection within in vitro models.