Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review

Migliorini, Filippo; Maffulli, Nicola; Baroncini, Alice; Knobe, Matthias; Tingart, Markus; Eschweiler, Jörg

Abstract

AbstractIntroductionChondral defects of the talus are common and their treatment is challenging.Source of dataRecent published literatures.Areas of agreementMembrane-induced Autologous Chondrocyte Implantation (mACI) and Autologous Matrix-Induced Chondrogenesis (AMIC) have been proposed as management for chondral defects of the talus.Areas of controversyIt is debated whether AMIC provides greater outcomes compared to mACI for chondral regeneration. Several clinical studies showed controversial results, and the best treatment has not yet been clarified.Growing pointsTo investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.Areas timely for developing researchAMIC exhibits similar clinical results to mACI. However, AMIC involves one single surgical procedure, no articular cartilage harvest and hence no morbidity from it, no need for chondrocyte expansion in a separate laboratory setting. For these reasons, AMIC may be preferred to mACI.

Citation

Migliorini, F., Maffulli, N., Baroncini, A., Knobe, M., Tingart, M., & Eschweiler, J. (2021). Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review. British Medical Bulletin, 138(1), 144-154. https://doi.org/10.1093/bmb/ldab008

• Journal Article Type: Article
• Acceptance Date: Feb 23, 2021
• Online Publication Date: May 3, 2021
• Publication Date: Jun 10, 2021
• Deposit Date: Jan 19, 2024
• Journal: British Medical Bulletin
• Print ISSN: 0007-1420
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 138
• Issue: 1
• Pages: 144-154
• DOI: https://doi.org/10.1093/bmb/ldab008
• Keywords: General Medicine
• Publisher URL: https://academic.oup.com/bmb/article/138/1/144/6261917