All Outputs (73)

Crystal structures of human SP-D complexed with synthetic oligosaccharides suggest a role for phosphorylated inner core LPS saccharides in host-pathogen interactions (2025)
Preprint / Working Paper
Williams, H. M., Watson, A., Madsen, J., Clark, H. W., Hood, D. W., Oscarson, S., Greenhough, T. J., & Shrive, A. K. (2025). Crystal structures of human SP-D complexed with synthetic oligosaccharides suggest a role for phosphorylated inner core LPS saccharides in host-pathogen interactions

The innate immune protein human surfactant protein D (SP-D) recognises pathogens in the lungs via binding to carbohydrate surface structures. SP-D has been shown to target gram-negative bacterial lipopolysaccharide via calcium-dependent binding, pref... Read More about Crystal structures of human SP-D complexed with synthetic oligosaccharides suggest a role for phosphorylated inner core LPS saccharides in host-pathogen interactions.

Diaspora Theoretical Contributors: Reframing Scholarly Identity and Intellectual Remittance (2025)
Preprint / Working Paper
Mogaji, E. (2025). Diaspora Theoretical Contributors: Reframing Scholarly Identity and Intellectual Remittance

With the rise of academic mobility and transnational research engagement, many scholars reside outside their countries of origin yet remain deeply connected to them through their scholarly work. This viewpoint introduces the concept of the diaspora t... Read More about Diaspora Theoretical Contributors: Reframing Scholarly Identity and Intellectual Remittance.

Not All Butterflies Are Monarchs: Compass Systems in the Red Admiral (Vanessa atalanta), a European Diurnal Migrant (2025)
Preprint / Working Paper
Pakhomov, A., Shapoval, N., Shapoval, A., & Kishkinev, D. (2025). Not All Butterflies Are Monarchs: Compass Systems in the Red Admiral (Vanessa atalanta), a European Diurnal Migrant

Seasonal migration in animals is a widespread and complex phenomenon, yet the mechanisms underlying orientation and navigation remain poorly understood in many taxa. While significant progress has been made in migratory birds, where multiple compass... Read More about Not All Butterflies Are Monarchs: Compass Systems in the Red Admiral (Vanessa atalanta), a European Diurnal Migrant.

Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial (2025)
Preprint / Working Paper
Bishop, F. L., Becque, T., Garfield, K., Cross, N., Dewar-Haggart, R., Teasdale, E., Herbert, A., Robinson, M. E., Ridd, M. J., Mallen, C., Clarson, L., Bostock, J., Stuart, B., Morrison, L., Pollet, S., Vennik, J., Atherton, H., Howick, J., Leydon, G. M., Nuttall, J., …Everitt, H. A. (2025). Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial

Objectives To determine the effectiveness and cost-effectiveness of a brief communication skills e-learning package on empathy and optimism for practitioners consulting with adult primary care patients presenting with musculoskeletal (MSK) pain.

D... Read More about Clinical and cost-effectiveness of communication skills e-learning for primary care practitioners on patients' musculoskeletal pain and enablement: the Talking in Primary care (TIP) cluster-randomised controlled trial.

The impact of wind mass loss on nucleosynthesis and yields of very massive stars at low metallicity (2025)
Preprint / Working Paper
Higgins, E. R., Vink, J. S., Hirschi, R., Laird, A. M., & Sabhahit, G. (2025). The impact of wind mass loss on nucleosynthesis and yields of very massive stars at low metallicity

The chemical feedback from stellar winds in low metallicity (Z) environments is key for understanding the evolution of globular clusters and the early Universe. With disproportionate mass lost from the most massive stars (M > 100Msun), and an excess... Read More about The impact of wind mass loss on nucleosynthesis and yields of very massive stars at low metallicity.

Detty December: Exploring The Economic Cultural And Policy Dimensions Of Africa 's Festive Phenomenon (2025)
Preprint / Working Paper
Kolade, S., Ugboma, O., Madichie, N., & Mogaji, E. Detty December: Exploring The Economic Cultural And Policy Dimensions Of Africa 's Festive Phenomenon. London

The Detty December webinar brought together experts in entrepreneurship, marketing, transportation, tourism, and policy development to explore the cultural, economic, and policy dimensions of this growing seasonal phenomenon in Africa, particularly i... Read More about Detty December: Exploring The Economic Cultural And Policy Dimensions Of Africa 's Festive Phenomenon.

Binarity at Low Metallicity (BLOeM) -- Multiplicity properties of Oe and Be stars (2025)
Preprint / Working Paper
Bodensteiner, J., Shenar, T., Sana, H., Britavskiy, N., Crowther, P., Langer, N., Lennon, D., Mahy, L., Patrick, L., Villaseñor, J., Abdul-Masih, M., Bowman, D., de Koter, A., de Mink, S., Deshmukh, K., Fabry, M., Gilkis, A., Götberg, Y., Holgado, G., Izzard, R., …-T. Xu, X. Binarity at Low Metallicity (BLOeM) -- Multiplicity properties of Oe and Be stars

Binarity at LOw Metallicity (BLOeM): The multiplicity properties and evolution of BAF-type supergiants (2025)
Preprint / Working Paper
Patrick, L., Lennon, D., Najarro, F., Shenar, T., Bodensteiner, J., Sana, H., Crowther, P., Britavskiy, N., Langer, N., Schootemeijer, A., Evans, C., Mahy, L., Götberg, Y., de Mink, S., Schneider, F., O'Grady, A., Villaseñor, J., Bernini-Peron, M., Bowman, D., de Koter, A., …Wang, C. Binarity at LOw Metallicity (BLOeM): The multiplicity properties and evolution of BAF-type supergiants

Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum (2025)
Preprint / Working Paper
Cockburn, N., Singh, M., Wambua, S., Gonzalez-Izquierdo, A., Ing Lee, S., Phillips, K., Elsmore, A., Ilaalagan, R., Holland, R., Hanley, S. J., Laws, E., Hodgetts-Morton, V., Gibbon, M., Judd, N. A., Seymour, R. G., Taylor, B., Singh Chandan, J., Parry-Smith, W., & Nirantharakumar, K. (2025). Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum

Background: Inequalities in pregnancy outcomes between different ethnic groups and backgrounds of deprivation have been observed in the UK and elsewhere for several decades. Pre-existing long-term health conditions increase risks of adverse outcomes... Read More about Ethnic and Socioeconomic Variation in Pre-Conception Long-Term Conditions: A Cross-Sectional Electronic Health Record Study of 3.4 Million Pregnancies in Cprd Aurum.

Rising temperatures favour parasite virulence and parallel molecular evolution following a host jump (2025)
Preprint / Working Paper
E Hector, T., M Kreiner, J., C Forward, J., L Hoang, K., J Stevens, E., Johnson, S., Li, J., & C King, K. Rising temperatures favour parasite virulence and parallel molecular evolution following a host jump

Climate change is facilitating the poleward emergence of parasites, increasing the risk of jumping into new animal species, including humans. Whether more virulent or transmissible variants will spread during these climate-driven outbreaks is unclear... Read More about Rising temperatures favour parasite virulence and parallel molecular evolution following a host jump.

Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study. (2024)
Preprint / Working Paper
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C. D., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2024). Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study

Background:

Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence–based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore... Read More about Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clinical Pharmacists in primary care Teams (PROMPPT). A non-randomised Mixed Methods Feasibility Study..

EWOCS-III: JWST observations of the supermassive star cluster Westerlund 1 (2024)
Preprint / Working Paper
Guarcello, M., Almendros-Abad, V., Lovell, J., Monsch, K., Muzic, K., Martiinez-Galarza, J., Drake, J., Anastasopoulou, K., Andersen, M., Argiroffi, C., Bayo, A., Bonito, R., Capela, D., Damiani, F., Gennaro, M., Ginsburg, A., Grebel, E., Hora, J., Moraux, E., Najarro, F., …Zeidler, P. EWOCS-III: JWST observations of the supermassive star cluster Westerlund 1

A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: a longitudinal validation study in rural India (2024)
Preprint / Working Paper
Bhavnani, S., Ranjan, A., Mukherjee, D., Divan, G., Prakash, A., Yadav, A., Lal, C., Gajria, D., Irfan, H., Sharma, K. K., Todkar, S. D., Patel, V., & McCray, G. A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: a longitudinal validation study in rural India

Background Cognitive development in early childhood is critical for life-long well-being. Existing cognitive development surveillance tools require lengthy parental interviews and observations of children. Developmental Assessment on an E-Platform (D... Read More about A non-specialist worker delivered digital assessment of cognitive development (DEEP) in young children: a longitudinal validation study in rural India.

Feasibility trial of a new digital training package to enhance primary care practitioners’ communication of clinical empathy and realistic optimism (2024)
Preprint / Working Paper
L Bishop, F., Howick, J., Vennik, J., Bostock, J., Little, P., Mallen, C., Morrison, L., Steele, M., Stuart, B., Hughes, S., Smith, K., Ratnapalan, M., Lyness, E., Dambha-Miller, H., Tiwari, R., Lockyer-Stevens, C., & Everitt, H. Feasibility trial of a new digital training package to enhance primary care practitioners’ communication of clinical empathy and realistic optimism

First Light and Reionisation Epoch Simulations (FLARES) XVII: Learning the galaxy-halo connection at high redshifts (2024)
Preprint / Working Paper
Maltz, M. G., Thomas, P., Lovell, C., Roper, W. J., Vijayan, A. P., Irodotou, D., Liao, S., Seeyave, L. T., & Wilkins, S. M. First Light and Reionisation Epoch Simulations (FLARES) XVII: Learning the galaxy-halo connection at high redshifts

Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model (2024)
Preprint / Working Paper
Shan, Y., Jiang, S., Yu, D., Fan, W., Gao, J., Lu, W., Duan, Y., Zhang, Y., Wang, S., Fu, H., & Wang, C. Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model

Background
As life expectancy increases, so does the risk of age-related diseases and functional disability, which significantly raises the risk of all-cause mortality in older adults. Individuals with disabilities may die up to 20 years earlier tha... Read More about Title: Prediction of Functional Disability in Older Chinese Adults Using a Random Survival Forest Model.

Association of air pollution from a landfill site with primary care consultation (2024)
Preprint / Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., Mallen, C. D., Mason, K. J., Wathall, S., & van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.

Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097) (2024)
Preprint / Working Paper
Wynne-Jones, G., Lewis, M., Sowden, G., Madan, I., Walker-Bone, K., Chew-Graham, C., Bromley, K., Jowett, S., Parsons, V., Mansell, G., Cooke, K., Lawton, S., Saunders, B., Pemberton, J., Cooper, C., & Foster, N. Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097)

Objectives To investigate the effectiveness of adding a brief vocational advice intervention to usual care in reducing the number of days absent from work over a period of 6 months in adults given a fit note by their general practice.

Design Multi... Read More about Protocol for the Work And Vocational advicE (WAVE) randomised controlled trial testing the addition of vocational advice to usual primary care (Clinical Trials: NCT04543097).

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype (2024)
Preprint / Working Paper
Ioannou, S., G Kay, A., P Stone, A., Rand, E., Elberfeld, S., Bolton, W., Larson, T., E Crossland, R., Kehoe, O., A Mentlak, D., Wang, X.-N., MacDonald, C., & Genever, P. Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype

Mesenchymal stromal cells (MSCs) are a promising source of therapeutic extracellular vesicles (EVs), however it is not clear how heterogeneity within a non-clonal MSC population will affect the collective EV pool. Here we used immortalised clonal MSC... Read More about Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtype.

Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis (2024)
Preprint / Working Paper
Stevens, E., Li, J., Hector, T., Drew, G., Hoang, K., Greenrod, S., Paterson, S., & King, K. Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis

Pathogens newly invading a host must compete with resident microbiota. This within-host microbial warfare could lead to more severe disease outcomes or constrain the evolution of virulence. Using experimental evolution of a widespread pathogen (Staph... Read More about Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis.