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All Outputs (1691)

Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate (2023)
Thesis
Brown-Lyons, A. L. (2023). Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate. (Thesis). Keele University

Background: Inflammation is a major driver, and perhaps cause, of neurodegeneration, suggesting neuroimmunomodulation as a therapeutic strategy. Microglia, the primary mediators of neuroinflammation, switch between three activation states [surveillan... Read More about Neural immune cell responses to clinically relevant ligands of the niacin receptor (Gpr109a): niacin and monomethyl fumarate.

Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay (2023)
Thesis
Freakley, A. L. (2023). Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay. (Thesis). Keele University

Leishmaniasis is a neglected tropical disease associated with poverty, deprived socio-economic settings and population displacement, primarily due to conflict. The causative agent are species of Leishmania parasites that are transmitted by sand flies... Read More about Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay.

Deciphering the atmospheric properties of hot gas giant exoplanets via ground-based transmission spectroscopy (2023)
Thesis
Spyratos, P. (2023). Deciphering the atmospheric properties of hot gas giant exoplanets via ground-based transmission spectroscopy. (Thesis). Keele University

Transiting hot gas giant exoplanets are great targets for atmospheric investigations due to their extended atmospheres and their strong obscuring effect on the observed starlight when they pass in front of their host star. Transmission spectroscopy c... Read More about Deciphering the atmospheric properties of hot gas giant exoplanets via ground-based transmission spectroscopy.

Fundamental parameters of very low mass stars in eclipsing binary star systems observed with the CHEOPS satellite (2023)
Thesis
Swayne, M. I. (2023). Fundamental parameters of very low mass stars in eclipsing binary star systems observed with the CHEOPS satellite. (Thesis). Keele University

Observations of low-mass stars have frequently shown unexpectedly large stellar radii when compared to the predictions from theoretical stellar structure models. This “radius inflation” problem may have consequences not just for stellar science but a... Read More about Fundamental parameters of very low mass stars in eclipsing binary star systems observed with the CHEOPS satellite.

Creative community groups as catalysts for health and wellbeing: An ethnographic study of arts participation in Stoke-on-Trent (UK) (2023)
Thesis
Fanthome, J. C. (2023). Creative community groups as catalysts for health and wellbeing: An ethnographic study of arts participation in Stoke-on-Trent (UK). (Thesis). Keele University

The role of creative activity for wellbeing is of growing interest, with third sector resources increasingly utilised to prevent the over-medicalisation of social problems. Experiences of community creative participation, however, are not well unders... Read More about Creative community groups as catalysts for health and wellbeing: An ethnographic study of arts participation in Stoke-on-Trent (UK).

The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity (2023)
Thesis
Tsang, K. S. (2023). The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity. (Thesis). Keele University

Spinal deformity involves a wide spectrum of disease, including congenital, developmental, degenerative and traumatic; affecting infant, adolescence and the elderly. Of these, Sheuermann’s kyphosis is a form of developmental long spinal deformity, ch... Read More about The effect of construct configuration on the mechanical stiffness and strength of spinal implants for kyphotic spinal deformity.

The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry (2023)
Thesis
Williams, M. F. (2023). The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry. (Thesis). Keele University

Statistics show that there was a 12% increase in missing persons’ incidents in the UK between 2014 and 2019. Approximately 50% of these missing individuals are found within 24 hours, and on average a large number will be deceased. Land-based searches... Read More about The evaluation of a metabonomic approach to detect decomposition products in water and leachates using Liquid Chromatography-Mass Spectrometry.

Understanding process of management control changes in hybrid organisational contracts (2023)
Thesis
Zaidi, U. (2023). Understanding process of management control changes in hybrid organisational contracts. (Thesis). Keele University

Motivated by controversial public and private sector hybrid organisational relationships and, more broadly, by repeated calls regarding control and management of hybrid organisational relationships, this thesis is concerned with the understanding pro... Read More about Understanding process of management control changes in hybrid organisational contracts.

Policing football in Sweden: a Participant Action Research project conducted with the football community (2023)
Thesis
Williams, N. S. (2023). Policing football in Sweden: a Participant Action Research project conducted with the football community. (Thesis). Keele University

This PhD thesis was written as part of a programme of research conducted by the Enable Project into the policing of domestic football events in Sweden. Between 2014 and 2016 Enable had conducted a series of Participant Action Research based observati... Read More about Policing football in Sweden: a Participant Action Research project conducted with the football community.

The role of Endothelial Progenitor Cells in the pleiotropic effects of Atorvastatin (2023)
Thesis
Sandhu, K. S. (2023). The role of Endothelial Progenitor Cells in the pleiotropic effects of Atorvastatin. (Thesis). Keele University

The following thesis began by discussing current controversies surrounding EPC identification then studied the effect of atorvastatin on EPC numbers in bench and bed side studies.
Atorvastatin was hypothesised to increase chemokine CXCL-12 its recep... Read More about The role of Endothelial Progenitor Cells in the pleiotropic effects of Atorvastatin.

The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice (2023)
Thesis
Kesavan, S. (2023). The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/515604

Varices are a complication of chronic liver disease and are associated with a high mortality if they haemorrhage. Patients need to be managed using the best available evidence to improve their outcomes. This thesis is formed of two parts: a systemati... Read More about The management of varices in acute on chronic liver failure: a systematic review of guidelines and investigation of local practice.

Radio and infrared surveys for active galactic nuclei behind the Magellanic Clouds (2023)
Thesis
Pennock, C. M. (2023). Radio and infrared surveys for active galactic nuclei behind the Magellanic Clouds. (Thesis). Keele University

I present an analysis of a new 120 deg2 radio continuum image of the Large Magellanic Cloud (LMC) at 888 MHz with a bandwidth of 288 MHz and beam size of 13.′′9×12.′′1, from the Australian Square Kilometre Array Pathfinder (ASKAP). I constructed a ca... Read More about Radio and infrared surveys for active galactic nuclei behind the Magellanic Clouds.

Statistical methods for prognostic factor and risk prediction research (2023)
Thesis
Whittle, R. L. (2023). Statistical methods for prognostic factor and risk prediction research. (Thesis). Keele University

Prognosis research is an important part of medical research as it seeks to understand, predict, and improve future outcomes in people with a given disease or health condition. This thesis focuses on the application and development of statistical meth... Read More about Statistical methods for prognostic factor and risk prediction research.

UAVS as a platform for earthwork heritage: monitoring, documentation and visualisation (2023)
Thesis
Malbon, H. (2023). UAVS as a platform for earthwork heritage: monitoring, documentation and visualisation. (Thesis). Keele University

Conservation of Cultural Heritage has been a mainstay of UNESCO and other such organisations for decades, whether it is artefacts, buildings, or earthworks. With the increase of tourism, urban encroachment, climate change, or naturally occurring proc... Read More about UAVS as a platform for earthwork heritage: monitoring, documentation and visualisation.

1. Franklyn’s Dog, 2. Trauma fiction : Enforcement, healingand the role of the perpetrator (2023)
Thesis
Cassam, S. J. (2023). 1. Franklyn’s Dog, 2. Trauma fiction : Enforcement, healingand the role of the perpetrator. (Thesis). Keele University

This thesis aims to explore current and emerging trends within trauma fiction and the criticism surrounding it. The thesis consists of a novel, Franklyn’s Dog, that focuses on the protagonist, Jon, and his attempts to overcome and move beyond the tra... Read More about 1. Franklyn’s Dog, 2. Trauma fiction : Enforcement, healingand the role of the perpetrator.

Hope and local food activism in a North Wales town: a conceptual and ethnographic study (2023)
Thesis
West, R. H. (2023). Hope and local food activism in a North Wales town: a conceptual and ethnographic study. (Thesis). Keele University

The aim of this thesis is to examine the relationship between hope and local food growing projects within a sustainability context. Hope has often been overlooked or dismissed as naïve in sociological and political discourse, while interstitial polit... Read More about Hope and local food activism in a North Wales town: a conceptual and ethnographic study.

Using Twitter to mobilise knowledge for First Contact Physiotherapists - A qualitative study (2023)
Thesis
Campbell, L. H. (2023). Using Twitter to mobilise knowledge for First Contact Physiotherapists - A qualitative study. (Thesis). Keele University

Background - First Contact Physiotherapists (FCPs) specialise in supporting people who consult with musculoskeletal conditions in National Health Service primary care. Cited FCP role challenges include professional isolation, time demands and changin... Read More about Using Twitter to mobilise knowledge for First Contact Physiotherapists - A qualitative study.

Conscious robots: what happens when a philosophical confusion becomes a societal reality? (2023)
Thesis
Ozdemir, S. (2023). Conscious robots: what happens when a philosophical confusion becomes a societal reality?. (Thesis). Keele University

This thesis is an investigation into philosophical issues surrounding the production of human-like robots. I will argue that there is no reason to think conscious robots will ever be built, but that supposedly conscious robots that are able to emulat... Read More about Conscious robots: what happens when a philosophical confusion becomes a societal reality?.

A social realist challenge to the structuring of professional practice knowledge for initial teacher education in England (2023)
Thesis
Swift, D. (2023). A social realist challenge to the structuring of professional practice knowledge for initial teacher education in England. (Thesis). Keele University

Professional practice knowledge for beginning teachers involves grappling with the extent to which ‘theory’ and ‘practice’ should be evident during initial teacher education courses. The end point assessment tool for such programmes in England is tha... Read More about A social realist challenge to the structuring of professional practice knowledge for initial teacher education in England.