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The effect of variation in interpretation of the La Trobe radiographic foot atlas on the prevalence of foot osteoarthritis in older women: the Chingford general population cohort. (2017)
Journal Article

Background: The prevalence of foot osteoarthritis (OA) is much less understood than hip, knee and hand OA. The foot is anatomically complex and different researchers have investigated different joints with lack of methodological standardisation acros... Read More about The effect of variation in interpretation of the La Trobe radiographic foot atlas on the prevalence of foot osteoarthritis in older women: the Chingford general population cohort..

The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol (2017)
Journal Article

INTRODUCTION: This pilot trial will inform the design and methods of a future full-scale randomized controlled trial (RCT) and examine the feasibility, acceptability and fidelity of the Increasing Physical activity in Older People with chronic Pain (... Read More about The feasibility and acceptability of a physical activity intervention for older people with chronic musculoskeletal pain: The iPOPP pilot trial protocol.

Uncertainties in the production of p nuclides in thermonuclear supernovae determined by Monte Carlo variations (2017)
Journal Article

Thermonuclear supernovae originating from the explosion of a white dwarf accreting mass from a companion star have been suggested as a site for the production of p nuclides. Such nuclei are produced during the explosion, in layers enriched with seed... Read More about Uncertainties in the production of p nuclides in thermonuclear supernovae determined by Monte Carlo variations.

The long-term impact of childhood wartime trauma on anxiety in later life: an exploration of the literature (2017)
Journal Article

At any point in time up to 10% of people over the age of 65 experience symptoms of anxiety. Yet the effects of anxiety in the older population are under-researched. Paternal separation in childhood has been cited as a factor for psychological well-be... Read More about The long-term impact of childhood wartime trauma on anxiety in later life: an exploration of the literature.

Possible detection of a bimodal cloud distribution in the atmosphere of HAT-P-32 A b from multiband photometry (2017)
Journal Article

We present high-precision photometry of eight separate transit events in the HAT-P-32 planetary system. One transit event was observed simultaneously by two telescopes of which one obtained a simultaneous multiband light curve in three optical bands,... Read More about Possible detection of a bimodal cloud distribution in the atmosphere of HAT-P-32 A b from multiband photometry.

ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells (2017)
Journal Article

There is considerable interest in redeploying drugs for use in combination with other oncology therapeutics. The single‑agent activity of statins in ovarian cancer has been widely reported, however the drug concentration required to cause cell death... Read More about ABT‑737 and pictilisib synergistically enhance pitavastatin‑induced apoptosis in ovarian cancer cells.

MANTA - A randomized phase II study of fulvestrant in combination with the dual mTOR inhibitor AZD2014 or everolimus or fulvestrant alone in estrogen receptor-positive advanced or metastatic breast cancer (2017)
Presentation / Conference

Background: Resistance to endocrine therapy remains a major clinical challenge with aberrant PI3K/ mTOR pathway activation being one of the main drivers. Randomised clinical trials have demonstrated a substantial benefit of adding everolimus to endoc... Read More about MANTA - A randomized phase II study of fulvestrant in combination with the dual mTOR inhibitor AZD2014 or everolimus or fulvestrant alone in estrogen receptor-positive advanced or metastatic breast cancer.

Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST). (2017)
Journal Article

BACKGROUND: Selection bias is a concern when designing cluster randomised controlled trials (c-RCT). Despite addressing potential issues at the design stage, bias cannot always be eradicated from a trial design. The application of bias analysis prese... Read More about Applying quantitative bias analysis to estimate the plausible effects of selection bias in a cluster randomised controlled trial: secondary analysis of the Primary care Osteoarthritis Screening Trial (POST)..

P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound (2017)
Journal Article

Introduction: Ischemic heart disease (IHD) has been associated with lower peak systolic velocity (PSV) on penile Doppler measurements [1]. This study establishes whether carotid ultrasound (US) PSV was associated with computational fluid dynamics (CF... Read More about P83: A Pilot Study to assess Peak Systolic Velocity as A Possible Marker of Atherosclerotic Burden Using Ultrasound.

A Preliminary Core Domain Set for Clinical Trials of Shoulder Disorders: A Report from the OMERACT 2016 Shoulder Core Outcome Set Special Interest Group (2017)
Journal Article

Objective. The Outcome Measures in Rheumatology (OMERACT) Shoulder Core Outcome Set Special Interest Group (SIG) was established to develop a core outcome set (COS) for clinical trials of shoulder disorders. Methods. In preparation for OMERACT 201... Read More about A Preliminary Core Domain Set for Clinical Trials of Shoulder Disorders: A Report from the OMERACT 2016 Shoulder Core Outcome Set Special Interest Group.