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All Outputs (1681)

An Isolated Stellar-Mass Black Hole Detected Through Astrometric Microlensing (2022)
Journal Article
Sahu, K. C., Anderson, J., Casertano, S., Bond, H. E., Udalski, A., Dominik, M., …Collaboration, R. (2022). An Isolated Stellar-Mass Black Hole Detected Through Astrometric Microlensing. Astrophysical Journal, 933(1),

We report the first unambiguous detection and mass measurement of an isolated stellar-mass black hole (BH). We used the Hubble Space Telescope (HST) to carry out precise astrometry of the source star of the long-duration (t_E ~ 270 days), high-magnif... Read More about An Isolated Stellar-Mass Black Hole Detected Through Astrometric Microlensing.

Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study. (2022)
Journal Article
Mamas. (2022). Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study. Open Heart, https://doi.org/10.1136/openhrt-2021-001881

OBJECTIVES: To understand the patient and hospital level drivers of the variation in surgical versus trascatheter aortic valve replacement (SAVR vs TAVR) for patients with aortic stenosis (AS) and to explore whether this variation translates into dif... Read More about Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study..

Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes (2022)
Journal Article
Mamas. (2022). Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes. Diabetes Care, 909-918. https://doi.org/10.2337/dc21-1113

OBJECTIVE To assess associations between current use of sodium–glucose cotransporter 2 inhibitors (SGLT2is), glucagon-like peptide 1 receptor agonists (GLP-1RAs), and their combination and risk for major adverse cardiac and cerebrovascular events (M... Read More about Primary Prevention of Cardiovascular and Heart Failure Events With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Their Combination in Type 2 Diabetes.

Factors Associated with Healing Outcomes in Primary Care Patients with Diabetic Foot Ulcers: A Retrospective Study in a Multiethnic Sample (2022)
Journal Article
Bajpai, R., Zhu, X., Olsson, M. M., Goh, L. J., & Lim, V. H. (2022). Factors Associated with Healing Outcomes in Primary Care Patients with Diabetic Foot Ulcers: A Retrospective Study in a Multiethnic Sample. Advances in skin & wound care, 35(1), 22 - 29. https://doi.org/10.1097/01.ASW.0000801524.42349.4d

OBJECTIVE To identify and determine patient- and ulcer-related factors associated with healing outcomes within 3 months for patients with diabetic foot ulcer (DFU) in a multiethnic primary care sample. METHODS Retrospective data were collected over 3... Read More about Factors Associated with Healing Outcomes in Primary Care Patients with Diabetic Foot Ulcers: A Retrospective Study in a Multiethnic Sample.

A sensitivity analysis of a single extraction well from deep geothermal aquifers in the Cheshire Basin, UK (2022)
Journal Article
Cassidy, N. J., Egan, S. S., Griffiths, D., & Brown, C. S. (2022). A sensitivity analysis of a single extraction well from deep geothermal aquifers in the Cheshire Basin, UK. Quarterly Journal of Engineering Geology and Hydrogeology, 55(3), Article qjegh2021-131. https://doi.org/10.1144/qjegh2021-131

Deep hot sedimentary aquifers (HSAs) are targeted for geothermal exploitation in the Cheshire Basin, UK. In this study, a single extraction well targeting the Collyhurst Sandstone Formation was modelled on MATLAB coupling heat and fluid flux. The Col... Read More about A sensitivity analysis of a single extraction well from deep geothermal aquifers in the Cheshire Basin, UK.

mixtur: An R package for designing, analysing, and modelling continuous report visual short-term memory studies (2022)
Journal Article
Grange. (2022). mixtur: An R package for designing, analysing, and modelling continuous report visual short-term memory studies. Behavior Research Methods, https://doi.org/10.3758/s13428-021-01688-1

Visual short-term memory (vSTM) is often measured via continuous-report tasks whereby participants are presented with stimuli that vary along a continuous dimension (e.g., colour) with the goal of memorising the stimulus features. At test, participan... Read More about mixtur: An R package for designing, analysing, and modelling continuous report visual short-term memory studies.

Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA (2022)
Journal Article
Chen, Y., Ma, Z., Yu, D., Jiang, Z., Wang, B., & Yuan, L. (2022). Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA. Environmental Geochemistry and Health, 44, 4423–4436. https://doi.org/10.1007/s10653-022-01204-0

Severe outcome particularly death is the largest burden of COVID-19. Clinical observations showed preliminary data that deficiency in certain trace elements, essential for the normal activity of immune system, may be associated with worse COVID-19 ou... Read More about Geographical distribution of trace elements (selenium, zinc, iron, copper) and case fatality rate of COVID-19: a national analysis across conterminous USA.

Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK (2022)
Journal Article
Taxiarchi, P., Kontopantelis, E., Kinnaird, T., Curzen, N., Ahmed, J., Zaman, A., …Mamas, M. A. (2022). Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK. Journal of Invasive Cardiology,

Objectives. This study examines the safety and feasibility of same-day discharge (SDD) in patients undergoing percutaneous coronary intervention (PCI) to coronary chronic total occlusions (CTOs) and explores independent associations of clinical and p... Read More about Same-Day Discharge After Elective Percutaneous Coronary Intervention for Chronic Total Occlusion in the UK.

What Does "Good" Community and Public Engagement Look Like? Developing Relationships With Community Members in Global Health Research. (2022)
Journal Article
(2022). What Does "Good" Community and Public Engagement Look Like? Developing Relationships With Community Members in Global Health Research. Frontiers in Public Health, 776940 - ?. https://doi.org/10.3389/fpubh.2021.776940

Community and public engagement (CPE) is increasingly becoming a key component in global health research. The National Institute for Health Research (NIHR) is one of the leading funders in the UK of global health research and requires a robust CPE el... Read More about What Does "Good" Community and Public Engagement Look Like? Developing Relationships With Community Members in Global Health Research..

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. (2022)
Journal Article
Reynisson. (2022). Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. Molecules, 1-14. https://doi.org/10.3390/molecules27030880

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in... Read More about Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action..

Aluminium co-localises with Biondi ring tangles in Parkinson’s disease and epilepsy (2022)
Journal Article
(2022). Aluminium co-localises with Biondi ring tangles in Parkinson’s disease and epilepsy. Scientific reports, https://doi.org/10.1038/s41598-022-05627-8

Aluminium is known to accumulate in neuropathological hallmarks. However, such has only tentatively been suggested in Biondi ring tangles. Owing to their intracellular and filamentous structure rich in beta-pleated sheets, Biondi ring tangles might a... Read More about Aluminium co-localises with Biondi ring tangles in Parkinson’s disease and epilepsy.

Transnational Healthcare Preferences Among EU Nationals in the UK: A Qualitative Assessment (2022)
Journal Article
Moreh, C., McGhee, D., & Vlachantoni, A. (2022). Transnational Healthcare Preferences Among EU Nationals in the UK: A Qualitative Assessment. Sociological Research Online, 28(2), 462-481. https://doi.org/10.1177/13607804211058744

This article explores the motivational factors behind preferences for medical care in the country of residence or the country of origin among EU nationals living in the UK. Undertaking a thematic analysis on a large-N qualitative data set, the articl... Read More about Transnational Healthcare Preferences Among EU Nationals in the UK: A Qualitative Assessment.

Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70. (2022)
Journal Article
Reynisson. (2022). Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70. Molecules, https://doi.org/10.3390/molecules27030817

Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HS... Read More about Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70..

An contextualized enamel growth rate and thickness data set collected from British populations spanning the past 2000 years. (2022)
Dataset
Aris, C. (2022). An contextualized enamel growth rate and thickness data set collected from British populations spanning the past 2000 years. [Dataset]. https://doi.org/10.26575/daj.v35i1.338

This article represents an open repository of human enamel data collected/reconstructed from seven populations covering a 2000 year time period in Britain via five temporally distinct periods. In total data was collected from 285 permanent teeth, inc... Read More about An contextualized enamel growth rate and thickness data set collected from British populations spanning the past 2000 years..

Rates and predictors of methotrexate-related adverse events in patients with early rheumatoid arthritis: results from a nationwide UK study. (2022)
Journal Article
(2022). Rates and predictors of methotrexate-related adverse events in patients with early rheumatoid arthritis: results from a nationwide UK study. https://doi.org/10.1093/rheumatology/keab917

OBJECTIVES: To estimate prevalence rates and identify baseline predictors of adverse events (AEs) over the first year of treatment in patients with RA starting MTX. METHODS: Data came from the UK Rheumatoid Arthritis Medication Study (RAMS), a prospe... Read More about Rates and predictors of methotrexate-related adverse events in patients with early rheumatoid arthritis: results from a nationwide UK study..