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Distribution, tolerance, growth, behaviour and control methods of <i>Limnoperna fortunei</i> (Dunker, 1857) (Bivalvia: Mytilidae): A review (2024)
Journal Article
Liu, Y., He, X., Yang, Y., Bai, X., & Yuan, C. (2024). Distribution, tolerance, growth, behaviour and control methods of Limnoperna fortunei (Dunker, 1857) (Bivalvia: Mytilidae): A review. Aquatic Conservation: Marine and Freshwater Ecosystems, 34(7), https://doi.org/10.1002/aqc.4217

Limnoperna fortunei (L. fortunei) (Dunker, 1857), the golden mussel, is an invasive species possessing exceptional environmental adaptability and a destructive impact on water systems and artificial structures. To better conservation of freshwater ec... Read More about Distribution, tolerance, growth, behaviour and control methods of <i>Limnoperna fortunei</i> (Dunker, 1857) (Bivalvia: Mytilidae): A review.

A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices. (2024)
Journal Article
Kranjec, C., Mathew, J. P., Ovchinnikov, K., Fadayomi, I., Yang, Y., Kjos, M., & Li, W.-W. (2024). A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices. Biofilm, 8, Article 100211. https://doi.org/10.1016/j.bioflm.2024.100211

The ever-increasing use of exogenous materials as indwelling medical devices in modern medicine offers to pathogens new ways to gain access to human body and begin, in some cases, life threatening infections. Biofouling of such materials with bacteri... Read More about A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices..

Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis (2024)
Journal Article
Echrish, J., Pasca, M.-I., Cabrera, D., Yang, Y., & Harper, A. G. S. (2024). Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis. Biomimetics, 9(6), Article 372. https://doi.org/10.3390/biomimetics9060372

Acute cardiovascular events result from clots caused by the rupture and erosion of atherosclerotic plaques. This paper aimed to produce a functional biomimetic hydrogel of the neointimal layer of the atherosclerotic plaque that can support thrombogen... Read More about Developing a Biomimetic 3D Neointimal Layer as a Prothrombotic Substrate for a Humanized In Vitro Model of Atherothrombosis.

Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples (2024)
Journal Article
Sharifabad, M. E., Eizadi Sharifabad, M., Soucaille, R., Wang, X., Rotherham, M., Loughran, T., …Telling, N. (2024). Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples. ACS Nano, 18(7), 5297-5310. https://doi.org/10.1021/acsnano.3c08955

The study of exogenous and endogenous nanoscale magnetic material in biology is important for developing biomedical nanotechnology as well as for understanding fundamental biological processes such as iron metabolism and biomineralization. Here, we e... Read More about Optical Microscopy Using the Faraday Effect Reveals in Situ Magnetization Dynamics of Magnetic Nanoparticles in Biological Samples.

Fabrication and Characterisation of Hydrogels with Reversible Wrinkled Surfaces for Limbal Study and Reconstruction (2023)
Journal Article
Dimmock, R. L., Rotherham, M., El Haj, A. J., & Yang, Y. (in press). Fabrication and Characterisation of Hydrogels with Reversible Wrinkled Surfaces for Limbal Study and Reconstruction. Gels, 9(11), Article 915. https://doi.org/10.3390/gels9110915

In the biomedical field, there is a demand for the development of novel approaches for the investigation of optical epithelial anatomical features with biomimetic materials. These materials are not only required to replicate structures but also enabl... Read More about Fabrication and Characterisation of Hydrogels with Reversible Wrinkled Surfaces for Limbal Study and Reconstruction.

Antifouling performance of D-enantiomers-based peptide-modified aluminum alloy surfaces with enhanced stability against proteolytic degradation (2023)
Journal Article
Lou, T., Bai, X., He, X., Liu, W., Yang, Z., Yang, Y., & Yuan, C. (2023). Antifouling performance of D-enantiomers-based peptide-modified aluminum alloy surfaces with enhanced stability against proteolytic degradation. Journal of Materials Science, 58, Article 15499–15512

Marine biofouling presents a significant challenge to the sustainable development of the maritime industry. Antimicrobial peptide (AMP) offers a promising strategy to combat biofouling. However, the inherent susceptibility of natural AMPs composed of... Read More about Antifouling performance of D-enantiomers-based peptide-modified aluminum alloy surfaces with enhanced stability against proteolytic degradation.

The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study (2023)
Journal Article
Jakobek, W., Gravino, G., Nayak, S., Yang, Y., Ranjbar, J., & Roffe, C. (in press). The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study. Interventional Neuroradiology, https://doi.org/10.1177/15910199231201518

Endovascular mechanical thrombectomy for ischaemic stroke is one of the most effective treatments. Despite the devices and techniques that have been developed, thrombi are not always successfully retrieved. The incidence of futile reperfusion after s... Read More about The effect of distal aspiration catheter position on collateral flow in mechanical thrombectomy - an in vitro study.

Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method (2023)
Journal Article
Wang, X., Cabrera, D., Yang, Y., & Telling, N. (in press). Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method. Frontiers in Nanotechnology, 5, Article 1214313. https://doi.org/10.3389/fnano.2023.1214313

Magnetic nanoparticles (MNPs) are promising as local heat generators for magnetic hyperthermia under AC magnetic fields. The heating efficacy of MNPs is determined by the AC hysteresis loop area, which in turn is affected by the dynamic magnetic prop... Read More about Probing magnetization dynamics of iron oxide nanoparticles using a point-probe magneto-optical method.

Developing Biomimetic Hydrogels of the Arterial Wall as a Prothrombotic Substrate for In Vitro Human Thrombosis Models (2023)
Journal Article
Ranjbar, J., Njoroge, W., Gibbins, J. M., Roach, P., Yang, Y., & Harper, A. G. S. (2023). Developing Biomimetic Hydrogels of the Arterial Wall as a Prothrombotic Substrate for In Vitro Human Thrombosis Models. Gels, 9(6), Article 477. https://doi.org/10.3390/gels9060477

Current in vitro thrombosis models utilise simplistic 2D surfaces coated with purified components of the subendothelial matrix. The lack of a realistic humanised model has led to greater study of thrombus formation in in vivo tests in animals. Here w... Read More about Developing Biomimetic Hydrogels of the Arterial Wall as a Prothrombotic Substrate for In Vitro Human Thrombosis Models.

Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties (2023)
Journal Article
Mason, J. H., Luo, L., Reinwald, Y., Taffetani, M., Hallas-Potts, A., Herrington, C. S., …Bagnaninchi, P. O. (2023). Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties. Communications Biology, 6(1), Article 543. https://doi.org/10.1038/s42003-023-04788-0

The role of the mechanical environment in defining tissue function, development and growth has been shown to be fundamental. Assessment of the changes in stiffness of tissue matrices at multiple scales has relied mostly on invasive and often speciali... Read More about Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties.

INVESTIGATION OF CELL AGGREGATE SIZE AND POTENTIAL BONE GROWTH WITH BONE CELL LINE AND HUMAN MESENCHYMAL STEM CELLS (2023)
Conference Proceeding
Deegan, A., Lawlor, L., Yang, X., & Yang, Y. (2023). INVESTIGATION OF CELL AGGREGATE SIZE AND POTENTIAL BONE GROWTH WITH BONE CELL LINE AND HUMAN MESENCHYMAL STEM CELLS. . https://doi.org/10.1302/1358-992x.2023.8.041

Our previous research has demonstrated that minor adjustments to in vitro cellular aggregation parameters, i.e. alterations to aggregate size, can influence temporal and spatial mineral depositions within maturing bone cell nodules. What remains uncl... Read More about INVESTIGATION OF CELL AGGREGATE SIZE AND POTENTIAL BONE GROWTH WITH BONE CELL LINE AND HUMAN MESENCHYMAL STEM CELLS.

Development of Boron-Containing PVA-Based Cryogels with Controllable Boron Releasing Rate and Altered Influence on Osteoblasts (2023)
Journal Article
Ceylan, S., Dimmock, R., & Yang, Y. (in press). Development of Boron-Containing PVA-Based Cryogels with Controllable Boron Releasing Rate and Altered Influence on Osteoblasts. Polymers, 15(7), 1653. https://doi.org/10.3390/polym15071653

Cryogel formation is an effective approach to produce porous scaffolds for tissue engineering. In this study, cryogelation was performed to produce boron-containing scaffolds for bone tissue engineering. A combination of the synthetic polymer, poly(v... Read More about Development of Boron-Containing PVA-Based Cryogels with Controllable Boron Releasing Rate and Altered Influence on Osteoblasts.

Automatic Detection of Skin Cancer Melanoma Using Transfer Learning in Deep Network (2023)
Journal Article
Wang, X., Yang, Y., & Mandal, B. (2023). Automatic Detection of Skin Cancer Melanoma Using Transfer Learning in Deep Network. AIP conference proceedings, 2562, Article ARTN 020009. https://doi.org/10.1063/5.0111909

As the deadliest type of skin cancer, melanoma has a high mortality rate and takes away thousands of lives in the UK every year. However, if detected at earlier stage, the survival rate largely increases. With the development of machine learning, man... Read More about Automatic Detection of Skin Cancer Melanoma Using Transfer Learning in Deep Network.

Enhanced antifouling properties of marine antimicrobial peptides by PEGylation. (2023)
Journal Article
Lou, T., Bai, X., He, X., Liu, W., Yang, Z., Yang, Y., & Yuan, C. (2023). Enhanced antifouling properties of marine antimicrobial peptides by PEGylation. Frontiers in Bioengineering and Biotechnology, 1124389 - ?. https://doi.org/10.3389/fbioe.2023.1124389

Covalent immobilisation of antimicrobial peptides (AMPs) on underwater surfaces to combat marine biofouling is of great interest as it is an efficient, broad-spectrum and environmentally friendly strategy. Similar to post-translational modifications... Read More about Enhanced antifouling properties of marine antimicrobial peptides by PEGylation..

Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling (2022)
Journal Article
Lou, T., Bai, X., He, X., Yang, Y., Yang, Z., & Yuan, C. (2022). Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling. China Surface Engineering, 35(2), 1-11. https://doi.org/10.11933/j.issn.1007-9289.20210611001

Marine biofouling is still a problem that needs to be urgently solved. However, comprehensive studies and reports on the research progress of antimicrobial peptides in the field of marine antifouling remain scant. Three types of antimicrobial peptide... Read More about Research Progress of Antimicrobial Peptides in the Field of Marine Antifouling.

Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation (2022)
Journal Article
Ranjbar, J., Yang, Y., & Harper, A. (2022). Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation. Platelets, 34(1), https://doi.org/10.1080/09537104.2022.2153823

Thrombus formation is highly dependent upon the physico-chemical environment in which it is triggered. Our ability to understand how thrombus formation is initiated, regulated, and resolved in the human body is dependent upon our ability to replicat... Read More about Developing human tissue engineered arterial constructs to simulate human in vivo thrombus formation.

Detection of lipid efflux from foam cell models using a label-free infrared method (2022)
Journal Article
Xie, B., Njoroge, W., Dowling, L. M., Sulé-Suso, J., Cinque, G., & Yang, Y. (2022). Detection of lipid efflux from foam cell models using a label-free infrared method. Analyst, 147(23), 5372-5385. https://doi.org/10.1039/D2AN01041K

Cardiovascular diseases are still among the leading causes of mortality and morbidity worldwide. The build-up of fatty plaques in the arteries, leading to atherosclerosis, is the most common cause of cardiovascular diseases. The central player in ath... Read More about Detection of lipid efflux from foam cell models using a label-free infrared method.

Antifouling performance and mechanism analysis of marine peptide modified aluminum alloy surface (2022)
Journal Article
Lou, T., Bai, X., He, X., Liu, W., Yang, Y., & Yuan, C. (2022). Antifouling performance and mechanism analysis of marine peptide modified aluminum alloy surface. Surface and Coatings Technology, 445, 128742. https://doi.org/10.1016/j.surfcoat.2022.128742

Biofouling, the settlement of nuisance fouling organisms on underwater surfaces, seriously affects the performance of the ship and the development of the maritime industry. Using antimicrobial peptides to obtain antifouling performance is one of the... Read More about Antifouling performance and mechanism analysis of marine peptide modified aluminum alloy surface.

Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds (2022)
Journal Article
Shen, H., Liu, J., Yan, X., Yang, H., Hu, S., Yan, X., …Lü, L. (2022). Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds. Colloids and Surfaces B: Biointerfaces, 213, 112419. https://doi.org/10.1016/j.colsurfb.2022.112419

In native bone tissue regeneration, blood vessels, providing oxygen and nutrition for tissues, can promote the regeneration of bone and accelerate the repair of a defected area. In this study, Poly(D, L-lactic-co-glycolic acid) (PLGA) inverse opal sc... Read More about Hydrostatic pressure stimulates the osteogenesis and angiogenesis of MSCs/HUVECs co-culture on porous PLGA scaffolds.