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Effect of volatile anaesthetic agents on intracranial pressure, cerebrovascular flow and autoregulation: a protocol for a systematic review and meta-analysis (2024)
Journal Article
Taylor, B., Ellis, J., Ponty, S., Patrick, L., Scott, T. E., & Chockalingam, N. (2024). Effect of volatile anaesthetic agents on intracranial pressure, cerebrovascular flow and autoregulation: a protocol for a systematic review and meta-analysis. BMJ Open, 14(9), https://doi.org/10.1136/bmjopen-2024-086727

Introduction: The use of volatile anaesthetic agents for the sedation of patients requiring critical care treatment offers several theoretical advantages over intravenous sedation, which may be of benefit in neurocritical care. However, there are con... Read More about Effect of volatile anaesthetic agents on intracranial pressure, cerebrovascular flow and autoregulation: a protocol for a systematic review and meta-analysis.

Defining an ageing-related pathology, disease or syndrome: International Consensus Statement (2024)
Journal Article
Short, E., ICCARP, Adcock, I. M., Al-Sarireh, B., Ager, A., Ajjan, R., …Bentley, B. (in press). Defining an ageing-related pathology, disease or syndrome: International Consensus Statement. GeroScience, https://doi.org/10.1007/s11357-024-01315-9

Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health sta... Read More about Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.

Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery (2024)
Journal Article
Hosseini, Z. S., Zeinalilathori, S., Fathi-karkan, S., Zeinali, S., Rahdar, A., Siddiqui, B., …Pandey, S. (in press). Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery. Journal of Drug Delivery Science and Technology, 106220. https://doi.org/10.1016/j.jddst.2024.106220

Bladder cancer poses considerable therapeutic difficulties owing to its elevated rates of recurrence and the constraints of existing treatment methods. This study examines the possibility of cell-targeting nanomedicine as a viable strategy to improve... Read More about Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery.

The role of primary care in depression relapse: a qualitative study. (2024)
Journal Article
Moriarty, A. S., Williams, E., McMillan, D., Gilbody, S., & Chew-Graham, C. A. (in press). The role of primary care in depression relapse: a qualitative study. British Journal of General Practice (BJGP), 1-28. https://doi.org/10.3399/BJGP.2024.0384

Background Relapse contributes to the clinical and societal burden associated with depression. It is not well understood how relapse risk and prevention are managed and discussed between patients and general practitioners in primary care. Aim To unde... Read More about The role of primary care in depression relapse: a qualitative study..

MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation (2024)
Journal Article
Al Saihati, H. A., Dessouky, A. A., Salim, R. F., Elgohary, I., El-Sherbiny, M., Ali, F. E. M., …Ebrahim, N. (in press). MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation. Stem Cell Research and Therapy, 15(1), 1-22. https://doi.org/10.1186/s13287-024-03889-9

Background: Coronavirus disease 2019 (COVID-19) has created a global pandemic with significant morbidity and mortality. SARS-CoV-2 primarily infects the lungs and is associated with various organ complications. Therapeutic approaches to combat COVID-... Read More about MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation.

Extinction Rebellion’s disobedient environmental citizenism (2024)
Journal Article
Hayes, G., Cammiss, S., Doherty, B., & Saunders, C. (in press). Extinction Rebellion’s disobedient environmental citizenism. Environmental Politics, 1-20. https://doi.org/10.1080/09644016.2024.2406183

We examine the public protest of Extinction Rebellion (XR) in the UK as a specific political practice. We do so through our observation of the plea hearings of activists charged with public order offences during the April 2019 London ‘Rebellion’, foc... Read More about Extinction Rebellion’s disobedient environmental citizenism.

Seven police officers and a WhatsApp group: What could go wrong? (2024)
Journal Article
Higson-Bliss, L. (in press). Seven police officers and a WhatsApp group: What could go wrong?. Journal of Criminal Law,

Provides a case comment on the recent matter of Cobban & Borders v DPP [2024] EWHC 1908 (Admin) following a High Court Appeal on the Appellants original convictions of sending grossly offensive communications as prohibited under to s.127(1) of the Co... Read More about Seven police officers and a WhatsApp group: What could go wrong?.

Exploring stroke survivors’ and physiotherapists’ perspectives of the potential for markerless motion capture technology in community rehabilitation (2024)
Journal Article
Faux-Nightingale, A., Philp, F., Leone, E., Boreman Helliwell, B., & Pandyan, A. (2024). Exploring stroke survivors’ and physiotherapists’ perspectives of the potential for markerless motion capture technology in community rehabilitation. Journal of NeuroEngineering and Rehabilitation, 21(1), Article 168. https://doi.org/10.1186/s12984-024-01467-x

Introduction: Many stroke survivors do not receive optimal levels of personalised therapy to support their recovery. Use of technology for stroke rehabilitation has increased in recent years to help minimise gaps in service provision. Markerless moti... Read More about Exploring stroke survivors’ and physiotherapists’ perspectives of the potential for markerless motion capture technology in community rehabilitation.

Gaia DR3 reveals the complex dynamical evolution within star clusters (2024)
Journal Article
Viscasillas Vázquez, C., Magrini, L., Miret-Roig, N., Wright, N., Alves, J., Spina, L., …Randich, S. (2024). Gaia DR3 reveals the complex dynamical evolution within star clusters. Astronomy & Astrophysics, 689, https://doi.org/10.1051/0004-6361/202450573

Context. Star clusters, composed of stars born from the same molecular cloud, serve as invaluable natural laboratories for understanding the fundamental processes governing stellar formation and evolution.

Aims. This study aims to investigate corr... Read More about Gaia DR3 reveals the complex dynamical evolution within star clusters.

O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS (2024)
Presentation / Conference
Jeyaraman, D., Peiris, T. D. P., Alahmdi, H., Fish, R., Lambie, M., & Wu, P. (2024, September). O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Presented at 30th Congress of the International Society of Hypertension, Cartegena de Indias, Colombia

Background and Objective: Acute kidney injury (AKI) is a common problem in pregnancy but adverse cardio-renal outcomes following AKI in pregnancy has not been systematically evaluated. We aimed to quantify the risk of adverse cardio-renal outcomes of... Read More about O24 ACUTE KIDNEY INJURY IN PREGNANCY AND CARDIO-RENAL OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS.

A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury (2024)
Journal Article
Kalsoum, R., Minns Lowe, C. J., Gilbert, S., McCaskie, A. W., Snow, M., Wright, K., …Watt, F. E. (in press). A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury. Bone & Joint Research, 13(9), 513-524. https://doi.org/10.1302/2046-3758.139.BJR-2024-0109

Aims
To explore key stakeholder views around feasibility and acceptability of trials seeking to prevent post-traumatic osteoarthritis (PTOA) following knee injury, and provide guidance for next steps in PTOA trial design.

Methods
Healthcare prof... Read More about A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury.

The Intersection of Socioeconomic Differences and Sex in the Management and Outcomes of Acute Myocardial Infarction: A Nationwide Cohort Study (2024)
Journal Article
Weight, N., Moledina, S., Lawson, C. A., Van Spall, H. G. C., Wijeysundera, H. C., Rashid, M., …Mamas, M. A. (in press). The Intersection of Socioeconomic Differences and Sex in the Management and Outcomes of Acute Myocardial Infarction: A Nationwide Cohort Study. Angiology, https://doi.org/10.1177/00033197241273433

Patients with lower socioeconomic status (SES) have poorer outcomes following acute myocardial infarction (AMI) than patients with higher SES; however, how sex modifies socioeconomic differences is unclear. Using the United Kingdom (UK) Myocardial Is... Read More about The Intersection of Socioeconomic Differences and Sex in the Management and Outcomes of Acute Myocardial Infarction: A Nationwide Cohort Study.

Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles (2024)
Journal Article
Ramsden, J. I., Zucoloto da Costa, B., Heath, R. S., Marshall, J. R., Derrington, S. R., Mangas-Sanchez, J., …Turner, N. J. (2024). Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles. ACS catalysis, 14(19), 14703-14710. https://doi.org/10.1021/acscatal.4c03832

Saturated N-heterocycles constitute a vital scaffold for pharmaceutical chemistry but are challenging to access synthetically, particularly asymmetrically. Here, we demonstrate how imine reductases can achieve annulation through tandem inter- and int... Read More about Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles.

Musculoskeletal patients’ preferences for care from physiotherapists or support workers: a discrete choice experiment (2024)
Journal Article
Sarigiovannis, P., Loría-Rebolledo, L. E., Foster, N. E., Jowett, S., & Saunders, B. (in press). Musculoskeletal patients’ preferences for care from physiotherapists or support workers: a discrete choice experiment. BMC Health Services Research, 24(1), Article 1095. https://doi.org/10.1186/s12913-024-11585-w

Background: Delegation of clinical tasks from physiotherapists to physiotherapy support workers is common yet varies considerably in musculoskeletal outpatient physiotherapy services, leading to variation in patient care. This study aimed to explore... Read More about Musculoskeletal patients’ preferences for care from physiotherapists or support workers: a discrete choice experiment.

Defining the Role of the Fire and Rescue Service in Mental Health Support for Older Adults: A Qualitative Study (2024)
Journal Article
Fisher, T., Chew‐Graham, C. A., Corp, N., Farooq, S., Kingston, P., Read, I., …Kingstone, T. (2024). Defining the Role of the Fire and Rescue Service in Mental Health Support for Older Adults: A Qualitative Study. Health Expectations, 27(5), Article e70028. https://doi.org/10.1111/hex.70028

Introduction: Anxiety and depression in older adults (60+ years of age) are under‐diagnosed and under‐treated. Older adults are less likely to seek help for these problems due to a lack of awareness, difficulty accessing health care due to availabili... Read More about Defining the Role of the Fire and Rescue Service in Mental Health Support for Older Adults: A Qualitative Study.

Can clinical presentation predict radiologically confirmed cauda equina syndrome: retrospective case review of 530 cases at a tertiary emergency department (2024)
Journal Article
Wood, L., Dunstan, E., Karouni, F., Zlatanos, C., Elkazaz, M., Salem, K. M. I., …Lewis, M. (in press). Can clinical presentation predict radiologically confirmed cauda equina syndrome: retrospective case review of 530 cases at a tertiary emergency department. European Spine Journal, https://doi.org/10.1007/s00586-024-08474-5

Purpose
Cauda equina syndrome (CES) may have significant individual consequences if diagnostic delays occur. Our aim was to evaluate the presenting subjective and objective features of patients with suspected CES in comparison to those with radiolog... Read More about Can clinical presentation predict radiologically confirmed cauda equina syndrome: retrospective case review of 530 cases at a tertiary emergency department.

Experience of choice of treatment for adults with depression: a systematic review and meta-synthesis of qualitative research (2024)
Journal Article
Megnin-Viggars, O., O’Donoghue, K., Pilling, S., & Chew-Graham, C. (in press). Experience of choice of treatment for adults with depression: a systematic review and meta-synthesis of qualitative research. Journal of Mental Health, 1-18. https://doi.org/10.1080/09638237.2024.2390369

Background
Treatment choices for depression are preference-sensitive (no “single best option”). However, factors or attributes that can enhance or inhibit patient choice have not been fully explored.

Aims
To synthesize the qualitative literature... Read More about Experience of choice of treatment for adults with depression: a systematic review and meta-synthesis of qualitative research.

Growth decline in European beech associated with temperature-driven increase in reproductive allocation (2024)
Working Paper
Hacket-Pain, A., Szymkowiak, J., Journe, V., Barczyk, M., Thomas, P., Lageard, J., …Bogdziewicz, M. Growth decline in European beech associated with temperature-driven increase in reproductive allocation

Climate change is impacting forests in complex ways, with indirect effects arising from interactions between tree growth and reproduction often overlooked. Our 43-year study of European beech (Fagus sylvatica), showed that rising summer temperatures... Read More about Growth decline in European beech associated with temperature-driven increase in reproductive allocation.

Mourning and orienting to the future in a liminal occasion: (re)defining British national identity after Queen Elizabeth II’s death (2024)
Journal Article
Vestergren, S. (in press). Mourning and orienting to the future in a liminal occasion: (re)defining British national identity after Queen Elizabeth II’s death. British Journal of Social Psychology,

In this paper we conceptualise the days of mourning that followed the passing of Queen Elizabeth II. as constituting a liminal occasion, a moment of in-betweenness through which we can explore sense-making in times of transition. How do people naviga... Read More about Mourning and orienting to the future in a liminal occasion: (re)defining British national identity after Queen Elizabeth II’s death.