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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. (2024)
Journal Article
Kelly, G., Kataura, T., Panek, J., Ma, G., Salmonowicz, H., Davis, A., …Korolchuk, V. I. (2024). Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. Developmental Cell, 59, 1-16. https://doi.org/10.1016/j.devcel.2024.04.020

Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to play an important role in cellular homeostasis. However, the molecular mechanisms and the requirement of mitochondrial quality control by mitophagy for cellular phy... Read More about Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule..

The potential of point-of-care ultrasound in UK general practice (2024)
Journal Article
Poppleton, A., Pursglove, L., Leceaga, E., Dupont, F., Hagiu, D.-P., & Andersen, C. (in press). The potential of point-of-care ultrasound in UK general practice. InnovAiT: Education and inspiration for general practice, https://doi.org/10.1177/17557380241257451

Ultrasound has been described as the stethoscope for the 21st century. It can rapidly answer a specific clinical question or support a procedure. Use of point-of-care ultrasound (PoCUS) by doctors has increased in the UK and internationally over the... Read More about The potential of point-of-care ultrasound in UK general practice.

Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences (2024)
Journal Article
Zaheer, A., Qiu, F., Manoragavan, R., Madan, M., Sud, M., Mamas, M. A., & Wijeysundera, H. C. (2024). Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences. Journal of the American Heart Association, 13(12), https://doi.org/10.1161/jaha.123.032450

Background Transcatheter aortic valve replacement (TAVR) has become the standard of care for severe aortic stenosis treatment. Exponential growth in demand has led to prolonged wait times and adverse patient outcomes. Social marginalization may contr... Read More about Impact of Neighborhood Social Deprivation on Delays to Access for Transcatheter Aortic Valve Replacement: Wait‐Times and Clinical Consequences.

Meta‐analysis and systematic review for anomaly network intrusion detection systems: Detection methods, dataset, validation methodology, and challenges (2024)
Journal Article
Maseer, Z. K., Kadhim, Q. K., Al‐Bander, B., Yusof, R., & Saif, A. (in press). Meta‐analysis and systematic review for anomaly network intrusion detection systems: Detection methods, dataset, validation methodology, and challenges. IET Networks, https://doi.org/10.1049/ntw2.12128

Intrusion detection systems built on artificial intelligence (AI) are presented as latent mechanisms for actively detecting fresh attacks over a complex network. The authors used a qualitative method for analysing and evaluating the performance of ne... Read More about Meta‐analysis and systematic review for anomaly network intrusion detection systems: Detection methods, dataset, validation methodology, and challenges.

Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector. (2024)
Journal Article
Mapua, S. A., Samb, B., Nambunga, I. H., Mkandawile, G., Bwanaly, H., Kaindoa, E. W., …Tripet, F. (2024). Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector. Parasites and Vectors, 17(1), 1-10. https://doi.org/10.1186/s13071-024-06348-9

Malaria transmission in Tanzania is driven by mosquitoes of the Anopheles gambiae complex and Anopheles funestus group. The latter includes An. funestus s.s., an anthropophilic vector, which is now strongly resistant to public health insecticides, an... Read More about Entomological survey of sibling species in the Anopheles funestus group in Tanzania confirms the role of Anopheles parensis as a secondary malaria vector..

Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review (2024)
Journal Article
Vervoort, D., Wang, R., Li, G., Filbey, L., Maduka, O., Brewer, L. C., …Van Spall, H. G. (2024). Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review. Journal of the American College of Cardiology, 83(25), 2690-2707. https://doi.org/10.1016/j.jacc.2024.04.028

Cardiovascular diseases (CVDs) are responsible for approximately 35% of all deaths in women. In 2019, the global age-standardized CVD prevalence and mortality of women were 6,403 per 100,000 and 204 per 100,000, respectively. Althou... Read More about Addressing the Global Burden of Cardiovascular Disease in Women JACC State-of-the-Art Review.

The Lived Experience of Informal Caregivers of People Who Have Severe Mental Illness and Coexisting Long-Term Conditions: A Qualitative Study. (2024)
Journal Article
Carswell, C., Brown, J. V. E., Shiers, D., Ajjan, R., Balogun-Katung, A., Bellass, S., …Coventry, P. (2024). The Lived Experience of Informal Caregivers of People Who Have Severe Mental Illness and Coexisting Long-Term Conditions: A Qualitative Study. Health Expectations, 27(3), 1-11. https://doi.org/10.1111/hex.14119

Background People with severe mental illness (SMI) experience higher rates and poorer outcomes of physical long-term conditions (LTCs). The management of SMI and LTCs is highly complex and many people with SMI rely on informal carers for support, wh... Read More about The Lived Experience of Informal Caregivers of People Who Have Severe Mental Illness and Coexisting Long-Term Conditions: A Qualitative Study..

Coproducing Health Information Materials With Young People: Reflections and Lessons Learned (2024)
Journal Article
Faux-Nightingale, A., Somayajula, G., Bradbury, C., Bray, L., Burton, C., Chew-Graham, C. A., …Welsh, V. (2024). Coproducing Health Information Materials With Young People: Reflections and Lessons Learned. Health Expectations, 27(3), Article e14115. https://doi.org/10.1111/hex.14115

Background This paper describes and critically reflects on how children and young people (CYP) acted as public advisors to co-produce health information materials about Long Covid for younger audiences. This work was underpinned by the Lundy model,... Read More about Coproducing Health Information Materials With Young People: Reflections and Lessons Learned.

Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records (2024)
Journal Article
Hussey, L. J., Kontopantelis, E., Mok, P. L. H., Ashcroft, D. M., Carr, M. J., Garg, S., …Webb, R. T. (in press). Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records. Journal of Child Psychology and Psychiatry, https://doi.org/10.1111/jcpp.14026

Background The impact of the COVID-19 pandemic on the mental health of children and young people (CYP) has been widely reported. Primary care electronic health records were utilised to examine trends in the diagnosing, recording and treating of thes... Read More about Socio‐demographic variation in diagnosis of and prescribing for common mental illnesses among children and young people during the COVID‐19 pandemic: time series analysis of primary care electronic health records.

NGTS-30b/TOI-4862b: An ~1 Gyr old 98-day transiting warm Jupiter (2024)
Journal Article
Battley, M. P., Collins, K. A., Ulmer-Moll, S., Quinn, S. N., Lendl, M., Gill, S., …Zhao, Y. (2024). NGTS-30b/TOI-4862b: An ~1 Gyr old 98-day transiting warm Jupiter. Astronomy & Astrophysics, 686, Article A230. https://doi.org/10.1051/0004-6361/202449307

Context. Long-period transiting exoplanets bridge the gap between the bulk of transit- and Doppler-based exoplanet discoveries, providing key insights into the formation and evolution of planetary systems. The wider separation between these planets a... Read More about NGTS-30b/TOI-4862b: An ~1 Gyr old 98-day transiting warm Jupiter.

F@#$ pain! A mini-review of the hypoalgesic effects of swearing (2024)
Journal Article
Hay, C. M., Sills, J. L., Shoemake, J. M., Ballmann, C. G., Stephens, R., & Washmuth, N. B. (in press). F@#$ pain! A mini-review of the hypoalgesic effects of swearing. Frontiers in Psychology, 15, Article 1416041. https://doi.org/10.3389/fpsyg.2024.1416041

Swearing, or the use of taboo language, has been repeatedly shown to induce hypoalgesia. While reliable hypoalgesic effects have been observed across studies, the mechanisms by which swearing influences pain and the optimal dosage of swearing remain... Read More about F@#$ pain! A mini-review of the hypoalgesic effects of swearing.

Minding some animals but not others: Strategic attributions of mental capacities and moral worth to animals used for food in pescatarians, vegetarians, and omnivores (2024)
Journal Article
Ioannidou, M., Francis, K. B., Stewart-Knox, B., & Lesk, V. (2024). Minding some animals but not others: Strategic attributions of mental capacities and moral worth to animals used for food in pescatarians, vegetarians, and omnivores. Appetite, 200, Article 107559. https://doi.org/10.1016/j.appet.2024.107559

While moral concern for animals has become increasingly important for both consumer food choice and food policy makers, previous research demonstrated that meat eaters attribute lower moral status and mental capacities to animals raised for meat comp... Read More about Minding some animals but not others: Strategic attributions of mental capacities and moral worth to animals used for food in pescatarians, vegetarians, and omnivores.

Long-term impact of type 2 diabetes onset on dementia incidence rate among New Zealanders with impaired glucose tolerance: A tapered-matched landmark analysis over 25 years (2024)
Journal Article
Yu, D., Wang, Z., Osuagwu, U. L., Pickering, K., Baker, J., Cutfield, R., …Simmons, D. (2024). Long-term impact of type 2 diabetes onset on dementia incidence rate among New Zealanders with impaired glucose tolerance: A tapered-matched landmark analysis over 25 years. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, https://doi.org/10.1002/alz.13855

INTRODUCTION We aimed to investigate the association between the onset of type 2 diabetes (T2D) and dementia incidence rates (IR) in the population with impaired glucose tolerance (IGT) identified in primary care in New Zealand (NZ) over 25 years.... Read More about Long-term impact of type 2 diabetes onset on dementia incidence rate among New Zealanders with impaired glucose tolerance: A tapered-matched landmark analysis over 25 years.

Fundamental effective temperature measurements for eclipsing binary stars – V. The circumbinary planet system EBLM J0608–59 (2024)
Journal Article
Maxted, P. F. L., Miller, N. J., Sebastian, D., Triaud, A. H. M. J., Martin, D. V., & Duck, A. (2024). Fundamental effective temperature measurements for eclipsing binary stars – V. The circumbinary planet system EBLM J0608–59. Monthly Notices of the Royal Astronomical Society, 531(4), 4577-4583. https://doi.org/10.1093/mnras/stae1434

EBLM J0608$-$59/TOI-1338/BEBOP-1 is a 12$^{\rm th}$-magnitude, F9 V star in an eclipsing binary with a much fainter M dwarf companion on a wide, eccentric orbit (P = 14.6 d). The binary is orbited by two circumbinary planets: one transiting on a 95-d... Read More about Fundamental effective temperature measurements for eclipsing binary stars – V. The circumbinary planet system EBLM J0608–59.

Could breathing frequency become a pragmatic means to monitor exercise intensity in atrial fibrillation and coronary heart disease? (2024)
Journal Article
Buckley, J. P., Terada, T., Lion, A., & Reed, J. L. (2024). Could breathing frequency become a pragmatic means to monitor exercise intensity in atrial fibrillation and coronary heart disease?. European Journal of Preventive Cardiology, 31(Supplement_1), i282. https://doi.org/10.1093/eurjpc/zwae175.197

Introduction Innovations Fund of the Alternate Funding Plan for the Academic Health Sciences Centre of the Ministry of Ontario, Canada; New Investigator Award in Clinical Rehabilitation from the Canadian Institute for Health Research; Heart and Strok... Read More about Could breathing frequency become a pragmatic means to monitor exercise intensity in atrial fibrillation and coronary heart disease?.

The Role of Higher Education in the Post-Truth Era (2024)
Journal Article
Parker, J. (2024). The Role of Higher Education in the Post-Truth Era. Journal of Political Science Education, 1-14. https://doi.org/10.1080/15512169.2024.2354972

The rise in populism and movements that threaten trust in science and expertise has been labelled a post-truth world. What challenges does this environment present for higher education, and how should it respond? This article examines the character... Read More about The Role of Higher Education in the Post-Truth Era.

Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. (2024)
Journal Article
Yang, M.-L., Hu, C.-Y., Lee, Y.-C., Chang, C.-C., Chen, Y.-C., Lee, P.-R., …Wu, P. (in press). Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy. Stem Cells Translational Medicine, Article szae039. https://doi.org/10.1093/stcltm/szae039

Oncolytic adenoviruses have emerged as a promising therapeutic approach for cancer therapy. However, systemic delivery of the viruses to metastatic tumors remains a major challenge. Mesenchymal stem cells (MSCs) possess tumor tropism property and can... Read More about Syngeneic mesenchymal stem cells loaded with telomerase-dependent oncolytic adenoviruses enhance anti-metastatic efficacy..