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Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa (2024)
Journal Article
Haga, I. R., Shih, B. B., Tore, G., Polo, N., Ribeca, P., Gombo-Ochir, D., …Beard, P. M. (in press). Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa. Viruses, 16(4), Article 557. https://doi.org/10.3390/v16040557

Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have... Read More about Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa.

Latent gammaherpesvirus infection enhances type I IFN response and reduces virus spread in an influenza A virus co-infection model. (2024)
Journal Article
Hardisty, G., Nicol, M. Q., Shaw, D. J., Bennet, I. D., Bryson, K., Ligertwood, Y., …Dutia, B. M. (2024). Latent gammaherpesvirus infection enhances type I IFN response and reduces virus spread in an influenza A virus co-infection model. Journal of General Virology, 105(2), https://doi.org/10.1099/jgv.0.001962

Infections with persistent or latent viruses alter host immune homeostasis and have potential to affect the outcome of concomitant acute viral infections such as influenza A virus (IAV). Gammaherpesviruses establish life-long infections and require a... Read More about Latent gammaherpesvirus infection enhances type I IFN response and reduces virus spread in an influenza A virus co-infection model..

Factors associated with foot-and-mouth disease seroprevalence in small ruminants and identification of hot-spot areas in northern Nigeria (2023)
Journal Article
Begovoeva, M., Ehizibolo, D. O., Adedeji, A. J., Oguche, M. O., Oyekan, O., Ijoma, S. I., …Limon, G. (2023). Factors associated with foot-and-mouth disease seroprevalence in small ruminants and identification of hot-spot areas in northern Nigeria. Preventive Veterinary Medicine, 212, Article 105842. https://doi.org/10.1016/j.prevetmed.2023.105842

The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022 (2022)
Journal Article
Beard. (2022). The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022. Eurosurveillance, https://doi.org/10.2807/1560-7917.es.2022.27.39.2200758

We report results of surveillance between June and mid-September 2022 of pet animals living in households of confirmed human monkeypox (MPX) cases. Since surveillance commenced, 154 animals from 40 households with a confirmed human MPX case were repo... Read More about The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022.

Identification of a Functional Small Noncoding RNA of African Swine Fever Virus (2020)
Journal Article
Dunn, L. E., Ivens, A., Netherton, C. L., Chapman, D. A., & Beard, P. M. (2020). Identification of a Functional Small Noncoding RNA of African Swine Fever Virus. Journal of Virology, 94(21), https://doi.org/10.1128/JVI.01515-20

African swine fever (ASF) poses a major threat to pig populations and food security worldwide. The disease is endemic to Africa and Eastern Europe and is rapidly emerging into Asia, where it has led to the deaths of millions of pigs in the last 12?mo... Read More about Identification of a Functional Small Noncoding RNA of African Swine Fever Virus.

Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line (2018)
Journal Article
Haga, I. R., Simpson, J. L., Hawes, P. C., & Beard, P. M. (2018). Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line. Scientific Reports, 8, Article 16956. https://doi.org/10.1038/s41598-018-34732-w

The re-emergence of poxviral zoonotic infections and the threat of bioterrorism emphasise the demand for efective antipoxvirus therapies. Here, we show that carbenoxolone, a pharmacological inhibitor of gap junction function and a compound widely... Read More about Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line.

Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats (2018)
Journal Article
Beard. (2018). Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats. American journal of physiology. Gastrointestinal and liver physiology, G388 - G398. https://doi.org/10.1152/ajpgi.00343.2017

Signaling via the colony-stimulating factor 1 receptor (CSF1R) controls the survival, differentiation, and proliferation of macrophages. Mutations in CSF1 or CSF1R in mice and rats have pleiotropic effects on postnatal somatic growth. We tested the p... Read More about Macrophage colony-stimulating factor increases hepatic macrophage content, liver growth, and lipid accumulation in neonatal rats.

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes (2017)
Journal Article
Almine, J. F., O’Hare, C. A., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., …Unterholzner, L. (2017). IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nature communications, 8, Article 14392. https://doi.org/10.1038/ncomms14392

AbstractMany human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other putative DNA receptors have been des... Read More about IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.

Vaccinia Virus Uses Retromer-Independent Cellular Retrograde Transport Pathways To Facilitate the Wrapping of Intracellular Mature Virions during Virus Morphogenesis (2016)
Journal Article
Harrison, K., Haga, I. R., Pechenick Jowers, T., Jasim, S., Cintrat, J., Gillet, D., …Beard, P. M. (2016). Vaccinia Virus Uses Retromer-Independent Cellular Retrograde Transport Pathways To Facilitate the Wrapping of Intracellular Mature Virions during Virus Morphogenesis. Journal of Virology, 90(22), 10120-10132. https://doi.org/10.1128/jvi.01464-16

Predicted optimum ambient temperatures for broiler chickens to dissipate metabolic heat do not affect performance or improve breast muscle quality (2016)
Journal Article
Beard. (2016). Predicted optimum ambient temperatures for broiler chickens to dissipate metabolic heat do not affect performance or improve breast muscle quality. British Poultry Science, 134 - 141. https://doi.org/10.1080/00071668.2015.1124067

An experiment was conducted to test the hypothesis that muscle damage in fast-growing broiler chickens is associated with an ambient temperature that does not permit the birds to lose metabolic heat resulting in physiological heat stress and a reduct... Read More about Predicted optimum ambient temperatures for broiler chickens to dissipate metabolic heat do not affect performance or improve breast muscle quality.

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice (2014)
Journal Article
Beard. (2014). Pleiotropic effects of extended blockade of CSF1R signaling in adult mice. Journal of Leukocyte Biology, 265 - 274. https://doi.org/10.1189/jlb.2A0114-006R

We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities. Mutation of the CSF1R has an even more penetrant... Read More about Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry (2014)
Journal Article
Beard. (2014). TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry. Journal of Virology, 3664 - 3677. https://doi.org/10.1128/JVI.03013-13

ABSTRACT Tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2) is a pivotal intracellular mediator of signaling pathways downstream of TNFR1 and -2 with known pro- and antiviral effects. We investigated its role in the replication of the... Read More about TRAF2 Facilitates Vaccinia Virus Replication by Promoting Rapid Virus Entry.

Influence of internalin a murinisation on host resistance to orally acquired listeriosis in mice (2013)
Journal Article
Beard. (2013). Influence of internalin a murinisation on host resistance to orally acquired listeriosis in mice. BMC Microbiology, https://doi.org/10.1186/1471-2180-13-90

Abstract Background The bacterial surface protein internalin (InlA) is a major virulence factor of the food-born pathogen Listeria monocytogenes. It plays a critical role in the bacteria crossing the host intestinal barrier by a species-specific int... Read More about Influence of internalin a murinisation on host resistance to orally acquired listeriosis in mice.